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Gene: SATB1 |
Gene summary for SATB1 |
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Gene information | Species | Human | Gene symbol | SATB1 | Gene ID | 6304 |
Gene name | SATB homeobox 1 | |
Gene Alias | DEFDA | |
Cytomap | 3p24.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A024R2H1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6304 | SATB1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.81e-06 | 1.64e-01 | 0.0155 |
6304 | SATB1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.14e-02 | 1.26e-01 | -0.1808 |
6304 | SATB1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-03 | 2.22e-01 | 0.0216 |
6304 | SATB1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.86e-06 | 2.21e-01 | -0.0811 |
6304 | SATB1 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.35e-11 | 3.25e-01 | -0.1088 |
6304 | SATB1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.88e-15 | 3.08e-01 | -0.1954 |
6304 | SATB1 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.61e-03 | 2.94e-01 | -0.2602 |
6304 | SATB1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.61e-02 | 9.39e-02 | -0.1464 |
6304 | SATB1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.00e-05 | 1.56e-01 | -0.1001 |
6304 | SATB1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.63e-07 | 2.38e-01 | -0.059 |
6304 | SATB1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.01e-11 | 3.55e-01 | -0.0179 |
6304 | SATB1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.21e-15 | 3.04e-01 | 0.096 |
6304 | SATB1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.45e-03 | 2.67e-01 | 0.0528 |
6304 | SATB1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.76e-07 | 4.31e-01 | 0.0131 |
6304 | SATB1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 9.21e-08 | 3.35e-01 | -0.0177 |
6304 | SATB1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.21e-02 | 2.06e-01 | 0.0171 |
6304 | SATB1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.64e-06 | 2.21e-01 | 0.0338 |
6304 | SATB1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.82e-13 | 2.89e-01 | 0.0674 |
6304 | SATB1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.70e-04 | 2.38e-01 | 0.0112 |
6304 | SATB1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 3.81e-02 | 2.45e-01 | -0.0124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0006338 | Colorectum | AD | chromatin remodeling | 70/3918 | 255/18723 | 7.44e-03 | 4.53e-02 | 70 |
GO:00063251 | Colorectum | SER | chromatin organization | 89/2897 | 409/18723 | 4.15e-04 | 6.17e-03 | 89 |
GO:00063252 | Colorectum | MSS | chromatin organization | 107/3467 | 409/18723 | 7.22e-05 | 1.21e-03 | 107 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:000632514 | Prostate | Tumor | chromatin organization | 104/3246 | 409/18723 | 2.02e-05 | 2.62e-04 | 104 |
GO:000633811 | Prostate | Tumor | chromatin remodeling | 63/3246 | 255/18723 | 1.73e-03 | 1.02e-02 | 63 |
GO:000632520 | Thyroid | PTC | chromatin organization | 183/5968 | 409/18723 | 2.55e-08 | 5.70e-07 | 183 |
GO:00063385 | Thyroid | PTC | chromatin remodeling | 106/5968 | 255/18723 | 6.56e-04 | 4.13e-03 | 106 |
GO:0006325110 | Thyroid | ATC | chromatin organization | 189/6293 | 409/18723 | 6.40e-08 | 1.13e-06 | 189 |
GO:000633813 | Thyroid | ATC | chromatin remodeling | 109/6293 | 255/18723 | 1.38e-03 | 7.15e-03 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SATB1 | SNV | Missense_Mutation | c.2194N>G | p.Leu732Val | p.L732V | Q01826 | protein_coding | tolerated(1) | benign(0.001) | TCGA-CR-7368-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | Complete Response | ||
SATB1 | SNV | Missense_Mutation | novel | c.388G>A | p.Gly130Arg | p.G130R | Q01826 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SATB1 | SNV | Missense_Mutation | c.914N>A | p.Pro305His | p.P305H | Q01826 | protein_coding | deleterious(0.02) | possibly_damaging(0.45) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SATB1 | SNV | Missense_Mutation | c.581N>C | p.Lys194Thr | p.K194T | Q01826 | protein_coding | deleterious(0) | possibly_damaging(0.843) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SATB1 | SNV | Missense_Mutation | rs777236078 | c.1985N>T | p.Thr662Met | p.T662M | Q01826 | protein_coding | tolerated(0.1) | possibly_damaging(0.738) | TCGA-BR-7703-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SATB1 | SNV | Missense_Mutation | rs776281718 | c.2227N>A | p.Gly743Ser | p.G743S | Q01826 | protein_coding | tolerated(0.16) | possibly_damaging(0.56) | TCGA-BR-8367-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | PD |
SATB1 | SNV | Missense_Mutation | c.1339N>A | p.Glu447Lys | p.E447K | Q01826 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
SATB1 | SNV | Missense_Mutation | c.2110N>A | p.Glu704Lys | p.E704K | Q01826 | protein_coding | deleterious(0) | benign(0.139) | TCGA-BR-A453-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
SATB1 | SNV | Missense_Mutation | c.1643A>G | p.Asn548Ser | p.N548S | Q01826 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |
SATB1 | SNV | Missense_Mutation | c.463N>C | p.Asp155His | p.D155H | Q01826 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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