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Gene: RBM6 |
Gene summary for RBM6 |
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Gene information | Species | Human | Gene symbol | RBM6 | Gene ID | 10180 |
Gene name | RNA binding motif protein 6 | |
Gene Alias | 3G2 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | A8K6Q4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10180 | RBM6 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.23e-09 | -3.73e-01 | 0.0155 |
10180 | RBM6 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.23e-04 | 4.89e-01 | -0.0811 |
10180 | RBM6 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.31e-14 | 6.78e-01 | -0.1954 |
10180 | RBM6 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.14e-03 | 4.16e-01 | -0.1001 |
10180 | RBM6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.15e-04 | 4.92e-01 | -0.059 |
10180 | RBM6 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.69e-03 | 6.37e-01 | 0.3487 |
10180 | RBM6 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.13e-14 | 8.27e-01 | 0.281 |
10180 | RBM6 | F007 | Human | Colorectum | FAP | 1.09e-02 | -1.49e-01 | 0.1176 |
10180 | RBM6 | A001-C-207 | Human | Colorectum | FAP | 3.13e-03 | -5.62e-02 | 0.1278 |
10180 | RBM6 | A015-C-203 | Human | Colorectum | FAP | 2.13e-28 | -1.33e-01 | -0.1294 |
10180 | RBM6 | A015-C-204 | Human | Colorectum | FAP | 3.63e-08 | -2.91e-01 | -0.0228 |
10180 | RBM6 | A014-C-040 | Human | Colorectum | FAP | 1.68e-02 | -7.46e-02 | -0.1184 |
10180 | RBM6 | A002-C-201 | Human | Colorectum | FAP | 3.26e-16 | 7.99e-02 | 0.0324 |
10180 | RBM6 | A001-C-119 | Human | Colorectum | FAP | 1.76e-10 | 1.24e-01 | -0.1557 |
10180 | RBM6 | A001-C-108 | Human | Colorectum | FAP | 2.76e-16 | -2.98e-02 | -0.0272 |
10180 | RBM6 | A002-C-205 | Human | Colorectum | FAP | 1.31e-30 | 1.42e-01 | -0.1236 |
10180 | RBM6 | A015-C-005 | Human | Colorectum | FAP | 3.30e-04 | -2.41e-01 | -0.0336 |
10180 | RBM6 | A015-C-006 | Human | Colorectum | FAP | 7.02e-21 | -1.66e-01 | -0.0994 |
10180 | RBM6 | A015-C-106 | Human | Colorectum | FAP | 8.51e-11 | -1.70e-01 | -0.0511 |
10180 | RBM6 | A002-C-114 | Human | Colorectum | FAP | 8.41e-26 | -1.22e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:00003772 | Colorectum | MSS | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003982 | Colorectum | MSS | mRNA splicing, via spliceosome | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003752 | Colorectum | MSS | RNA splicing, via transesterification reactions | 122/3467 | 324/18723 | 2.75e-16 | 8.58e-14 | 122 |
GO:00083803 | Colorectum | MSI-H | RNA splicing | 82/1319 | 434/18723 | 1.22e-16 | 4.53e-14 | 82 |
GO:00003753 | Colorectum | MSI-H | RNA splicing, via transesterification reactions | 67/1319 | 324/18723 | 7.99e-16 | 2.61e-13 | 67 |
GO:00003773 | Colorectum | MSI-H | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 66/1319 | 320/18723 | 1.51e-15 | 4.41e-13 | 66 |
GO:00003983 | Colorectum | MSI-H | mRNA splicing, via spliceosome | 66/1319 | 320/18723 | 1.51e-15 | 4.41e-13 | 66 |
GO:00083804 | Colorectum | FAP | RNA splicing | 108/2622 | 434/18723 | 7.90e-10 | 1.86e-07 | 108 |
GO:00003754 | Colorectum | FAP | RNA splicing, via transesterification reactions | 84/2622 | 324/18723 | 8.06e-09 | 1.10e-06 | 84 |
GO:00003774 | Colorectum | FAP | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 83/2622 | 320/18723 | 9.66e-09 | 1.23e-06 | 83 |
GO:00003984 | Colorectum | FAP | mRNA splicing, via spliceosome | 83/2622 | 320/18723 | 9.66e-09 | 1.23e-06 | 83 |
GO:00083805 | Colorectum | CRC | RNA splicing | 90/2078 | 434/18723 | 2.80e-09 | 7.97e-07 | 90 |
GO:00003775 | Colorectum | CRC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 66/2078 | 320/18723 | 4.39e-07 | 3.37e-05 | 66 |
GO:00003985 | Colorectum | CRC | mRNA splicing, via spliceosome | 66/2078 | 320/18723 | 4.39e-07 | 3.37e-05 | 66 |
GO:00003755 | Colorectum | CRC | RNA splicing, via transesterification reactions | 66/2078 | 324/18723 | 7.00e-07 | 4.61e-05 | 66 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RBM6 | SNV | Missense_Mutation | novel | c.97N>A | p.Pro33Thr | p.P33T | P78332 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.963) | TCGA-CV-7415-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RBM6 | SNV | Missense_Mutation | novel | c.1903N>T | p.Thr635Ser | p.T635S | P78332 | protein_coding | tolerated(1) | benign(0) | TCGA-D6-6823-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RBM6 | deletion | Frame_Shift_Del | c.293delG | p.Gly98GlufsTer56 | p.G98Efs*56 | P78332 | protein_coding | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
RBM6 | insertion | Frame_Shift_Ins | rs775573264 | c.2494_2495insA | p.Pro835ThrfsTer9 | p.P835Tfs*9 | P78332 | protein_coding | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
RBM6 | SNV | Missense_Mutation | rs369268393 | c.755N>T | p.Thr252Met | p.T252M | P78332 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-J4-A83J-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD |
RBM6 | SNV | Missense_Mutation | rs749549620 | c.2582N>T | p.Thr861Met | p.T861M | P78332 | protein_coding | tolerated(0.07) | benign(0.425) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RBM6 | SNV | Missense_Mutation | c.1975A>G | p.Met659Val | p.M659V | P78332 | protein_coding | deleterious(0.05) | benign(0.127) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
RBM6 | SNV | Missense_Mutation | rs780711178 | c.2495N>G | p.Glu832Gly | p.E832G | P78332 | protein_coding | tolerated(0.32) | benign(0) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RBM6 | SNV | Missense_Mutation | c.2626N>A | p.Asp876Asn | p.D876N | P78332 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
RBM6 | SNV | Missense_Mutation | rs779354599 | c.1985N>A | p.Arg662His | p.R662H | P78332 | protein_coding | deleterious(0.04) | probably_damaging(0.938) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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