![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: RBM33 |
Gene summary for RBM33 |
![]() |
Gene information | Species | Human | Gene symbol | RBM33 | Gene ID | 155435 |
Gene name | RNA binding motif protein 33 | |
Gene Alias | PRR8 | |
Cytomap | 7q36.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q96EV2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
155435 | RBM33 | CA_HPV_1 | Human | Cervix | CC | 1.87e-04 | -9.60e-02 | 0.0264 |
155435 | RBM33 | CCI_2 | Human | Cervix | CC | 4.26e-03 | 5.96e-01 | 0.5249 |
155435 | RBM33 | CCI_3 | Human | Cervix | CC | 3.47e-03 | 5.46e-01 | 0.516 |
155435 | RBM33 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.16e-15 | -5.23e-01 | 0.0155 |
155435 | RBM33 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.53e-02 | -6.74e-01 | 0.0216 |
155435 | RBM33 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.69e-05 | -5.28e-01 | -0.1207 |
155435 | RBM33 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.21e-08 | -3.45e-01 | -0.1464 |
155435 | RBM33 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.17e-05 | -3.58e-01 | -0.1001 |
155435 | RBM33 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.79e-08 | -4.44e-01 | 0.096 |
155435 | RBM33 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.11e-02 | -5.48e-01 | 0.0528 |
155435 | RBM33 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.87e-03 | -4.54e-01 | 0.0338 |
155435 | RBM33 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.74e-11 | -4.52e-01 | 0.0674 |
155435 | RBM33 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.84e-04 | -2.57e-01 | 0.3859 |
155435 | RBM33 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.58e-11 | -4.88e-01 | 0.3005 |
155435 | RBM33 | A002-C-010 | Human | Colorectum | FAP | 2.97e-03 | -7.78e-02 | 0.242 |
155435 | RBM33 | A015-C-203 | Human | Colorectum | FAP | 2.23e-29 | -3.38e-01 | -0.1294 |
155435 | RBM33 | A015-C-204 | Human | Colorectum | FAP | 4.65e-04 | -1.23e-01 | -0.0228 |
155435 | RBM33 | A014-C-040 | Human | Colorectum | FAP | 1.05e-05 | -2.16e-01 | -0.1184 |
155435 | RBM33 | A002-C-201 | Human | Colorectum | FAP | 3.78e-11 | -2.37e-01 | 0.0324 |
155435 | RBM33 | A002-C-203 | Human | Colorectum | FAP | 1.48e-04 | 1.53e-01 | 0.2786 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RBM33 | SNV | Missense_Mutation | novel | c.965C>T | p.Pro322Leu | p.P322L | Q96EV2 | protein_coding | tolerated(0.79) | benign(0.372) | TCGA-60-2714-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
RBM33 | SNV | Missense_Mutation | novel | c.3309G>C | p.Glu1103Asp | p.E1103D | Q96EV2 | protein_coding | tolerated(0.12) | probably_damaging(0.99) | TCGA-85-7950-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RBM33 | insertion | Nonsense_Mutation | novel | c.479_480insGATGTA | p.Ile160delinsMetMetTer | p.I160delinsMM* | Q96EV2 | protein_coding | TCGA-55-8505-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR | ||
RBM33 | SNV | Missense_Mutation | rs780064963 | c.1121C>A | p.Pro374Gln | p.P374Q | Q96EV2 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-CR-7388-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
RBM33 | SNV | Missense_Mutation | c.251N>A | p.Ser84Tyr | p.S84Y | Q96EV2 | protein_coding | deleterious(0.01) | benign(0.246) | TCGA-CV-7255-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
RBM33 | SNV | Missense_Mutation | novel | c.2146N>A | p.Ser716Thr | p.S716T | Q96EV2 | protein_coding | tolerated(0.26) | possibly_damaging(0.647) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RBM33 | SNV | Missense_Mutation | novel | c.2951A>T | p.Lys984Met | p.K984M | Q96EV2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-HD-8635-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RBM33 | SNV | Missense_Mutation | rs758201933 | c.1049N>T | p.Pro350Leu | p.P350L | Q96EV2 | protein_coding | tolerated(0.93) | benign(0.009) | TCGA-UF-A7JH-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RBM33 | SNV | Missense_Mutation | rs148804732 | c.2152N>A | p.Val718Met | p.V718M | Q96EV2 | protein_coding | deleterious(0.04) | probably_damaging(0.969) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
RBM33 | SNV | Missense_Mutation | rs762485406 | c.2396N>A | p.Arg799His | p.R799H | Q96EV2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |