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Gene: RAPH1 |
Gene summary for RAPH1 |
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Gene information | Species | Human | Gene symbol | RAPH1 | Gene ID | 65059 |
Gene name | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | |
Gene Alias | ALS2CR18 | |
Cytomap | 2q33.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q70E73 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65059 | RAPH1 | CCI_2 | Human | Cervix | CC | 3.05e-15 | 1.24e+00 | 0.5249 |
65059 | RAPH1 | CCI_3 | Human | Cervix | CC | 9.26e-07 | 4.71e-01 | 0.516 |
65059 | RAPH1 | T3 | Human | Cervix | CC | 4.21e-03 | 2.21e-01 | 0.1389 |
65059 | RAPH1 | AEH-subject1 | Human | Endometrium | AEH | 5.73e-08 | 3.21e-01 | -0.3059 |
65059 | RAPH1 | AEH-subject4 | Human | Endometrium | AEH | 4.07e-02 | 3.12e-01 | -0.2657 |
65059 | RAPH1 | AEH-subject5 | Human | Endometrium | AEH | 7.51e-18 | 5.63e-01 | -0.2953 |
65059 | RAPH1 | EEC-subject1 | Human | Endometrium | EEC | 4.49e-08 | 3.79e-01 | -0.2682 |
65059 | RAPH1 | EEC-subject3 | Human | Endometrium | EEC | 8.16e-05 | 3.54e-01 | -0.2525 |
65059 | RAPH1 | EEC-subject4 | Human | Endometrium | EEC | 1.76e-02 | 2.20e-01 | -0.2571 |
65059 | RAPH1 | EEC-subject5 | Human | Endometrium | EEC | 1.01e-02 | 2.09e-01 | -0.249 |
65059 | RAPH1 | LZE4T | Human | Esophagus | ESCC | 2.04e-08 | 1.19e-01 | 0.0811 |
65059 | RAPH1 | LZE5T | Human | Esophagus | ESCC | 1.71e-02 | 8.06e-02 | 0.0514 |
65059 | RAPH1 | LZE20T | Human | Esophagus | ESCC | 2.69e-03 | 3.37e-02 | 0.0662 |
65059 | RAPH1 | LZE24T | Human | Esophagus | ESCC | 9.56e-08 | 2.01e-01 | 0.0596 |
65059 | RAPH1 | P2T-E | Human | Esophagus | ESCC | 1.78e-11 | 1.06e-01 | 0.1177 |
65059 | RAPH1 | P4T-E | Human | Esophagus | ESCC | 5.46e-14 | 2.56e-01 | 0.1323 |
65059 | RAPH1 | P5T-E | Human | Esophagus | ESCC | 3.83e-07 | 1.10e-01 | 0.1327 |
65059 | RAPH1 | P8T-E | Human | Esophagus | ESCC | 5.32e-11 | 1.87e-01 | 0.0889 |
65059 | RAPH1 | P9T-E | Human | Esophagus | ESCC | 1.19e-12 | 2.02e-01 | 0.1131 |
65059 | RAPH1 | P10T-E | Human | Esophagus | ESCC | 9.06e-04 | -9.60e-03 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160498 | Cervix | CC | cell growth | 92/2311 | 482/18723 | 1.16e-05 | 2.49e-04 | 92 |
GO:00615647 | Cervix | CC | axon development | 89/2311 | 467/18723 | 1.71e-05 | 3.27e-04 | 89 |
GO:00074097 | Cervix | CC | axonogenesis | 78/2311 | 418/18723 | 1.14e-04 | 1.43e-03 | 78 |
GO:00605606 | Cervix | CC | developmental growth involved in morphogenesis | 46/2311 | 234/18723 | 8.82e-04 | 7.63e-03 | 46 |
GO:00486756 | Cervix | CC | axon extension | 26/2311 | 120/18723 | 2.80e-03 | 1.87e-02 | 26 |
GO:19901385 | Cervix | CC | neuron projection extension | 34/2311 | 172/18723 | 3.52e-03 | 2.27e-02 | 34 |
GO:00485886 | Cervix | CC | developmental cell growth | 42/2311 | 234/18723 | 7.88e-03 | 4.15e-02 | 42 |
GO:00160499 | Endometrium | AEH | cell growth | 93/2100 | 482/18723 | 1.00e-07 | 4.99e-06 | 93 |
GO:00605607 | Endometrium | AEH | developmental growth involved in morphogenesis | 53/2100 | 234/18723 | 4.02e-07 | 1.67e-05 | 53 |
GO:00074098 | Endometrium | AEH | axonogenesis | 81/2100 | 418/18723 | 5.54e-07 | 2.12e-05 | 81 |
GO:00615648 | Endometrium | AEH | axon development | 88/2100 | 467/18723 | 6.39e-07 | 2.38e-05 | 88 |
GO:00486757 | Endometrium | AEH | axon extension | 31/2100 | 120/18723 | 6.13e-06 | 1.50e-04 | 31 |
GO:00485887 | Endometrium | AEH | developmental cell growth | 48/2100 | 234/18723 | 2.39e-05 | 4.53e-04 | 48 |
GO:19901386 | Endometrium | AEH | neuron projection extension | 38/2100 | 172/18723 | 3.03e-05 | 5.56e-04 | 38 |
GO:006156412 | Endometrium | EEC | axon development | 93/2168 | 467/18723 | 9.60e-08 | 4.69e-06 | 93 |
GO:001604915 | Endometrium | EEC | cell growth | 95/2168 | 482/18723 | 1.16e-07 | 5.54e-06 | 95 |
GO:006056013 | Endometrium | EEC | developmental growth involved in morphogenesis | 54/2168 | 234/18723 | 4.60e-07 | 1.78e-05 | 54 |
GO:000740912 | Endometrium | EEC | axonogenesis | 82/2168 | 418/18723 | 1.03e-06 | 3.49e-05 | 82 |
GO:004867513 | Endometrium | EEC | axon extension | 31/2168 | 120/18723 | 1.17e-05 | 2.43e-04 | 31 |
GO:004858813 | Endometrium | EEC | developmental cell growth | 49/2168 | 234/18723 | 2.59e-05 | 4.56e-04 | 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAPH1 | SNV | Missense_Mutation | rs774194590 | c.3559N>T | p.Arg1187Cys | p.R1187C | Q70E73 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.854) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
RAPH1 | SNV | Missense_Mutation | novel | c.2159N>T | p.Thr720Ile | p.T720I | Q70E73 | protein_coding | tolerated_low_confidence(0.18) | benign(0.202) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
RAPH1 | insertion | Frame_Shift_Ins | novel | c.3708_3709insA | p.Pro1237ThrfsTer35 | p.P1237Tfs*35 | Q70E73 | protein_coding | TCGA-V1-A9OQ-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 6 | Unknown | Unknown | SD | ||
RAPH1 | SNV | Missense_Mutation | c.617A>T | p.Asn206Ile | p.N206I | Q70E73 | protein_coding | deleterious_low_confidence(0) | benign(0.178) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |
RAPH1 | SNV | Missense_Mutation | c.2059N>T | p.Pro687Ser | p.P687S | Q70E73 | protein_coding | deleterious_low_confidence(0.03) | benign(0.231) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RAPH1 | SNV | Missense_Mutation | c.1715N>G | p.Ile572Ser | p.I572S | Q70E73 | protein_coding | tolerated(0.09) | benign(0) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RAPH1 | SNV | Missense_Mutation | c.646G>T | p.Ala216Ser | p.A216S | Q70E73 | protein_coding | tolerated(0.14) | benign(0.283) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RAPH1 | SNV | Missense_Mutation | novel | c.1871N>A | p.Pro624His | p.P624H | Q70E73 | protein_coding | tolerated_low_confidence(0.22) | benign(0.003) | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR |
RAPH1 | SNV | Missense_Mutation | rs145036827 | c.463N>A | p.Asp155Asn | p.D155N | Q70E73 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.949) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
RAPH1 | SNV | Missense_Mutation | novel | c.2288N>A | p.Pro763His | p.P763H | Q70E73 | protein_coding | tolerated_low_confidence(0.08) | possibly_damaging(0.779) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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