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Gene: PRRC2A |
Gene summary for PRRC2A |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PRRC2A | Gene ID | 7916 |
| Gene name | proline rich coiled-coil 2A | |
| Gene Alias | BAT2 | |
| Cytomap | 6p21.33 | |
| Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A1U9X974 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7916 | PRRC2A | HTA11_347_2000001011 | Human | Colorectum | AD | 4.06e-06 | 2.64e-01 | -0.1954 |
| 7916 | PRRC2A | HTA11_83_2000001011 | Human | Colorectum | SER | 6.53e-03 | 2.48e-01 | -0.1526 |
| 7916 | PRRC2A | HTA11_696_2000001011 | Human | Colorectum | AD | 3.43e-08 | 3.90e-01 | -0.1464 |
| 7916 | PRRC2A | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.74e-06 | 4.53e-01 | -0.059 |
| 7916 | PRRC2A | HTA11_866_3004761011 | Human | Colorectum | AD | 3.73e-05 | 3.40e-01 | 0.096 |
| 7916 | PRRC2A | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.98e-04 | 3.61e-01 | 0.0674 |
| 7916 | PRRC2A | HTA11_11156_2000001011 | Human | Colorectum | AD | 3.83e-03 | 6.30e-01 | 0.0397 |
| 7916 | PRRC2A | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.60e-07 | 4.69e-01 | 0.0588 |
| 7916 | PRRC2A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.60e-12 | 5.96e-01 | 0.3859 |
| 7916 | PRRC2A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.17e-03 | 3.39e-01 | 0.3005 |
| 7916 | PRRC2A | A015-C-203 | Human | Colorectum | FAP | 2.12e-03 | -8.91e-03 | -0.1294 |
| 7916 | PRRC2A | A015-C-104 | Human | Colorectum | FAP | 4.94e-04 | -9.28e-02 | -0.1899 |
| 7916 | PRRC2A | A002-C-116 | Human | Colorectum | FAP | 2.54e-04 | -1.26e-01 | -0.0452 |
| 7916 | PRRC2A | LZE4T | Human | Esophagus | ESCC | 5.31e-15 | 4.63e-01 | 0.0811 |
| 7916 | PRRC2A | LZE5T | Human | Esophagus | ESCC | 5.32e-03 | 1.90e-01 | 0.0514 |
| 7916 | PRRC2A | LZE7T | Human | Esophagus | ESCC | 2.08e-18 | 1.13e+00 | 0.0667 |
| 7916 | PRRC2A | LZE8T | Human | Esophagus | ESCC | 2.02e-08 | 3.51e-01 | 0.067 |
| 7916 | PRRC2A | LZE20T | Human | Esophagus | ESCC | 9.79e-09 | 4.72e-01 | 0.0662 |
| 7916 | PRRC2A | LZE22D1 | Human | Esophagus | HGIN | 1.27e-03 | 1.01e-01 | 0.0595 |
| 7916 | PRRC2A | LZE22T | Human | Esophagus | ESCC | 4.80e-03 | 3.37e-01 | 0.068 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PRRC2A | SNV | Missense_Mutation | novel | c.2800C>T | p.Arg934Cys | p.R934C | P48634 | protein_coding | deleterious(0) | possibly_damaging(0.855) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PRRC2A | SNV | Missense_Mutation | novel | c.238N>T | p.Pro80Ser | p.P80S | P48634 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PRRC2A | SNV | Missense_Mutation | rs762876043 | c.1171N>A | p.Ala391Thr | p.A391T | P48634 | protein_coding | deleterious(0.04) | probably_damaging(0.984) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PRRC2A | SNV | Missense_Mutation | rs150100255 | c.2411N>A | p.Arg804His | p.R804H | P48634 | protein_coding | tolerated(0.1) | probably_damaging(0.996) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PRRC2A | SNV | Missense_Mutation | novel | c.3071N>C | p.Arg1024Pro | p.R1024P | P48634 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PRRC2A | SNV | Missense_Mutation | rs750172164 | c.5792C>T | p.Pro1931Leu | p.P1931L | P48634 | protein_coding | tolerated_low_confidence(0.07) | benign(0.074) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PRRC2A | SNV | Missense_Mutation | c.2386T>C | p.Phe796Leu | p.F796L | P48634 | protein_coding | deleterious(0.01) | probably_damaging(0.931) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
| PRRC2A | SNV | Missense_Mutation | novel | c.5606N>T | p.Pro1869Leu | p.P1869L | P48634 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PRRC2A | insertion | In_Frame_Ins | novel | c.2519_2520insGCTCCACCACCTGCAGTCCCTAAAGAA | p.Gly840_Phe841insLeuHisHisLeuGlnSerLeuLysAsn | p.G840_F841insLHHLQSLKN | P48634 | protein_coding | TCGA-AP-A05D-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | ||
| PRRC2A | deletion | Frame_Shift_Del | c.5649delC | p.Gly1884AlafsTer12 | p.G1884Afs*12 | P48634 | protein_coding | TCGA-AP-A0LD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 7916 | PRRC2A | NA | carbamazepine | CARBAMAZEPINE | 16538176 | |
| 7916 | PRRC2A | NA | carboplatin | CARBOPLATIN | 31616045 | |
| 7916 | PRRC2A | NA | gemcitabine | GEMCITABINE | 31616045 |
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