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Gene: POLR1A |
Gene summary for POLR1A |
Gene summary. |
Gene information | Species | Human | Gene symbol | POLR1A | Gene ID | 25885 |
Gene name | RNA polymerase I subunit A | |
Gene Alias | A190 | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O95602 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25885 | POLR1A | LZE7T | Human | Esophagus | ESCC | 7.76e-08 | 2.06e-01 | 0.0667 |
25885 | POLR1A | LZE24T | Human | Esophagus | ESCC | 7.67e-11 | 1.35e-01 | 0.0596 |
25885 | POLR1A | P2T-E | Human | Esophagus | ESCC | 1.61e-23 | 3.73e-01 | 0.1177 |
25885 | POLR1A | P4T-E | Human | Esophagus | ESCC | 1.66e-12 | 2.55e-01 | 0.1323 |
25885 | POLR1A | P5T-E | Human | Esophagus | ESCC | 1.12e-11 | 1.67e-01 | 0.1327 |
25885 | POLR1A | P8T-E | Human | Esophagus | ESCC | 9.99e-10 | 1.30e-01 | 0.0889 |
25885 | POLR1A | P9T-E | Human | Esophagus | ESCC | 6.98e-06 | 1.40e-01 | 0.1131 |
25885 | POLR1A | P10T-E | Human | Esophagus | ESCC | 2.08e-29 | 4.73e-01 | 0.116 |
25885 | POLR1A | P11T-E | Human | Esophagus | ESCC | 1.72e-04 | 3.20e-01 | 0.1426 |
25885 | POLR1A | P12T-E | Human | Esophagus | ESCC | 8.54e-15 | 1.99e-01 | 0.1122 |
25885 | POLR1A | P15T-E | Human | Esophagus | ESCC | 7.20e-11 | 2.15e-01 | 0.1149 |
25885 | POLR1A | P16T-E | Human | Esophagus | ESCC | 8.00e-14 | 2.32e-01 | 0.1153 |
25885 | POLR1A | P17T-E | Human | Esophagus | ESCC | 9.21e-07 | 1.64e-01 | 0.1278 |
25885 | POLR1A | P19T-E | Human | Esophagus | ESCC | 1.58e-02 | 2.40e-01 | 0.1662 |
25885 | POLR1A | P20T-E | Human | Esophagus | ESCC | 6.35e-11 | 2.88e-01 | 0.1124 |
25885 | POLR1A | P21T-E | Human | Esophagus | ESCC | 9.65e-16 | 2.90e-01 | 0.1617 |
25885 | POLR1A | P22T-E | Human | Esophagus | ESCC | 6.27e-11 | 1.83e-01 | 0.1236 |
25885 | POLR1A | P23T-E | Human | Esophagus | ESCC | 8.12e-10 | 2.27e-01 | 0.108 |
25885 | POLR1A | P24T-E | Human | Esophagus | ESCC | 3.13e-08 | 1.68e-01 | 0.1287 |
25885 | POLR1A | P26T-E | Human | Esophagus | ESCC | 8.01e-17 | 3.38e-01 | 0.1276 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:190018018 | Esophagus | ESCC | regulation of protein localization to nucleus | 102/8552 | 136/18723 | 2.84e-12 | 1.13e-10 | 102 |
GO:00063602 | Esophagus | ESCC | transcription by RNA polymerase I | 42/8552 | 55/18723 | 3.41e-06 | 3.78e-05 | 42 |
GO:19038289 | Esophagus | ESCC | negative regulation of cellular protein localization | 76/8552 | 117/18723 | 1.97e-05 | 1.72e-04 | 76 |
GO:190257011 | Esophagus | ESCC | protein localization to nucleolus | 13/8552 | 16/18723 | 4.05e-03 | 1.62e-02 | 13 |
GO:003450421 | Liver | HCC | protein localization to nucleus | 194/7958 | 290/18723 | 2.84e-17 | 2.85e-15 | 194 |
GO:190018012 | Liver | HCC | regulation of protein localization to nucleus | 95/7958 | 136/18723 | 9.26e-11 | 3.26e-09 | 95 |
GO:190382811 | Liver | HCC | negative regulation of cellular protein localization | 71/7958 | 117/18723 | 5.44e-05 | 5.12e-04 | 71 |
GO:0006360 | Liver | HCC | transcription by RNA polymerase I | 36/7958 | 55/18723 | 4.94e-04 | 3.23e-03 | 36 |
GO:19025701 | Liver | HCC | protein localization to nucleolus | 13/7958 | 16/18723 | 1.84e-03 | 9.42e-03 | 13 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0302021 | Esophagus | ESCC | RNA polymerase | 28/4205 | 34/8465 | 8.19e-05 | 3.35e-04 | 1.71e-04 | 28 |
hsa0302031 | Esophagus | ESCC | RNA polymerase | 28/4205 | 34/8465 | 8.19e-05 | 3.35e-04 | 1.71e-04 | 28 |
hsa03020 | Liver | HCC | RNA polymerase | 24/4020 | 34/8465 | 5.40e-03 | 1.57e-02 | 8.75e-03 | 24 |
hsa030201 | Liver | HCC | RNA polymerase | 24/4020 | 34/8465 | 5.40e-03 | 1.57e-02 | 8.75e-03 | 24 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLR1A | SNV | Missense_Mutation | c.3523N>A | p.Ala1175Thr | p.A1175T | O95602 | protein_coding | tolerated(0.52) | benign(0.324) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
POLR1A | SNV | Missense_Mutation | c.179N>T | p.Ser60Phe | p.S60F | O95602 | protein_coding | deleterious(0.03) | possibly_damaging(0.827) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
POLR1A | SNV | Missense_Mutation | c.2663N>G | p.Gln888Arg | p.Q888R | O95602 | protein_coding | tolerated(0.44) | benign(0.029) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
POLR1A | SNV | Missense_Mutation | c.464N>A | p.Ser155Tyr | p.S155Y | O95602 | protein_coding | tolerated(1) | benign(0.001) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
POLR1A | SNV | Missense_Mutation | novel | c.755N>G | p.Lys252Arg | p.K252R | O95602 | protein_coding | tolerated(0.2) | benign(0.11) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
POLR1A | SNV | Missense_Mutation | c.1693N>T | p.Arg565Cys | p.R565C | O95602 | protein_coding | tolerated(0.2) | benign(0.007) | TCGA-D1-A177-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
POLR1A | SNV | Missense_Mutation | novel | c.4898G>A | p.Gly1633Asp | p.G1633D | O95602 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
POLR1A | SNV | Missense_Mutation | rs185258869 | c.4681C>T | p.Arg1561Trp | p.R1561W | O95602 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POLR1A | SNV | Missense_Mutation | novel | c.3936C>A | p.Phe1312Leu | p.F1312L | O95602 | protein_coding | tolerated(0.45) | benign(0.003) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POLR1A | SNV | Missense_Mutation | c.3416N>T | p.Ala1139Val | p.A1139V | O95602 | protein_coding | tolerated(0.2) | benign(0.081) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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