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Gene: PLEKHA6 |
Gene summary for PLEKHA6 |
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Gene information | Species | Human | Gene symbol | PLEKHA6 | Gene ID | 22874 |
Gene name | pleckstrin homology domain containing A6 | |
Gene Alias | PEPP-3 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q9Y2H5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22874 | PLEKHA6 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.23e-35 | 1.13e+00 | -0.1954 |
22874 | PLEKHA6 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.03e-14 | 1.29e+00 | -0.2602 |
22874 | PLEKHA6 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.54e-08 | 6.91e-01 | -0.1526 |
22874 | PLEKHA6 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.23e-23 | 9.67e-01 | -0.1464 |
22874 | PLEKHA6 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.78e-20 | 8.10e-01 | -0.1001 |
22874 | PLEKHA6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.27e-11 | 8.63e-01 | -0.059 |
22874 | PLEKHA6 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.52e-03 | 5.81e-01 | -0.1706 |
22874 | PLEKHA6 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.88e-05 | 6.67e-01 | -0.0842 |
22874 | PLEKHA6 | HTA11_6818_2000001011 | Human | Colorectum | AD | 3.78e-05 | 6.35e-01 | 0.0112 |
22874 | PLEKHA6 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.27e-02 | 4.92e-01 | 0.281 |
22874 | PLEKHA6 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.38e-05 | -3.66e-01 | 0.3005 |
22874 | PLEKHA6 | A015-C-203 | Human | Colorectum | FAP | 3.16e-32 | -4.48e-01 | -0.1294 |
22874 | PLEKHA6 | A015-C-204 | Human | Colorectum | FAP | 2.24e-05 | -1.69e-01 | -0.0228 |
22874 | PLEKHA6 | A014-C-040 | Human | Colorectum | FAP | 4.47e-05 | -4.51e-01 | -0.1184 |
22874 | PLEKHA6 | A002-C-201 | Human | Colorectum | FAP | 5.00e-12 | -2.19e-01 | 0.0324 |
22874 | PLEKHA6 | A002-C-203 | Human | Colorectum | FAP | 1.24e-02 | 7.07e-02 | 0.2786 |
22874 | PLEKHA6 | A001-C-119 | Human | Colorectum | FAP | 4.54e-14 | -6.28e-01 | -0.1557 |
22874 | PLEKHA6 | A001-C-108 | Human | Colorectum | FAP | 1.40e-19 | -3.83e-01 | -0.0272 |
22874 | PLEKHA6 | A002-C-205 | Human | Colorectum | FAP | 5.63e-23 | -3.33e-01 | -0.1236 |
22874 | PLEKHA6 | A001-C-104 | Human | Colorectum | FAP | 2.47e-03 | -2.17e-01 | 0.0184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLEKHA6 | SNV | Missense_Mutation | c.586A>T | p.Asn196Tyr | p.N196Y | Q9Y2H5 | protein_coding | deleterious(0.03) | benign(0.305) | TCGA-73-4668-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | pemetrexed | PD | |
PLEKHA6 | SNV | Missense_Mutation | c.1775N>C | p.Leu592Pro | p.L592P | Q9Y2H5 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-99-8028-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PLEKHA6 | SNV | Missense_Mutation | c.1183G>T | p.Ala395Ser | p.A395S | Q9Y2H5 | protein_coding | tolerated(1) | benign(0) | TCGA-34-5236-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
PLEKHA6 | SNV | Missense_Mutation | c.2428G>C | p.Val810Leu | p.V810L | Q9Y2H5 | protein_coding | tolerated(0.05) | benign(0) | TCGA-34-8455-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
PLEKHA6 | SNV | Missense_Mutation | novel | c.976N>T | p.Arg326Trp | p.R326W | Q9Y2H5 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-37-4132-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PLEKHA6 | SNV | Missense_Mutation | c.137N>T | p.Gly46Val | p.G46V | Q9Y2H5 | protein_coding | deleterious(0.01) | possibly_damaging(0.617) | TCGA-39-5024-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD | |
PLEKHA6 | SNV | Missense_Mutation | rs759317655 | c.2428N>A | p.Val810Met | p.V810M | Q9Y2H5 | protein_coding | deleterious(0) | benign(0.216) | TCGA-51-4081-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
PLEKHA6 | SNV | Missense_Mutation | novel | c.421N>A | p.Glu141Lys | p.E141K | Q9Y2H5 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-77-7465-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PLEKHA6 | SNV | Missense_Mutation | novel | c.719C>T | p.Pro240Leu | p.P240L | Q9Y2H5 | protein_coding | tolerated(0.2) | benign(0.022) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PLEKHA6 | SNV | Missense_Mutation | novel | c.1625A>T | p.Lys542Met | p.K542M | Q9Y2H5 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-NC-A5HJ-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
22874 | PLEKHA6 | NA | haloperidol | HALOPERIDOL | 27023437 |
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