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Gene: PHLPP1 |
Gene summary for PHLPP1 |
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Gene information | Species | Human | Gene symbol | PHLPP1 | Gene ID | 23239 |
Gene name | PH domain and leucine rich repeat protein phosphatase 1 | |
Gene Alias | PHLPP | |
Cytomap | 18q21.33 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | O60346 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23239 | PHLPP1 | CCI_1 | Human | Cervix | CC | 6.83e-18 | 9.88e-01 | 0.528 |
23239 | PHLPP1 | CCI_2 | Human | Cervix | CC | 4.87e-12 | 1.38e+00 | 0.5249 |
23239 | PHLPP1 | CCI_3 | Human | Cervix | CC | 2.54e-25 | 1.01e+00 | 0.516 |
23239 | PHLPP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.27e-24 | -6.06e-01 | 0.0155 |
23239 | PHLPP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.79e-02 | -4.40e-01 | -0.1808 |
23239 | PHLPP1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.14e-03 | -6.92e-01 | 0.0216 |
23239 | PHLPP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.70e-04 | -4.59e-01 | -0.1207 |
23239 | PHLPP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.82e-05 | -3.33e-01 | -0.1464 |
23239 | PHLPP1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.89e-05 | -5.39e-01 | -0.2061 |
23239 | PHLPP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.77e-05 | -4.71e-01 | 0.096 |
23239 | PHLPP1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.48e-03 | -6.14e-01 | 0.0528 |
23239 | PHLPP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.27e-06 | -4.11e-01 | 0.0674 |
23239 | PHLPP1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.56e-02 | -4.50e-01 | 0.0588 |
23239 | PHLPP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.78e-05 | -3.61e-01 | 0.294 |
23239 | PHLPP1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.45e-05 | -3.20e-01 | 0.281 |
23239 | PHLPP1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.53e-22 | -6.25e-01 | 0.3859 |
23239 | PHLPP1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.44e-13 | -8.94e-01 | 0.2585 |
23239 | PHLPP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.78e-35 | -7.78e-01 | 0.3005 |
23239 | PHLPP1 | F007 | Human | Colorectum | FAP | 6.76e-03 | -2.75e-01 | 0.1176 |
23239 | PHLPP1 | A001-C-207 | Human | Colorectum | FAP | 4.57e-05 | -3.03e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00310988 | Cervix | CC | stress-activated protein kinase signaling cascade | 58/2311 | 247/18723 | 8.02e-07 | 2.89e-05 | 58 |
GO:00485118 | Cervix | CC | rhythmic process | 65/2311 | 298/18723 | 2.79e-06 | 8.04e-05 | 65 |
GO:00514038 | Cervix | CC | stress-activated MAPK cascade | 55/2311 | 239/18723 | 2.96e-06 | 8.31e-05 | 55 |
GO:00703027 | Cervix | CC | regulation of stress-activated protein kinase signaling cascade | 46/2311 | 195/18723 | 9.35e-06 | 2.11e-04 | 46 |
GO:00064708 | Cervix | CC | protein dephosphorylation | 60/2311 | 281/18723 | 1.33e-05 | 2.68e-04 | 60 |
GO:00328727 | Cervix | CC | regulation of stress-activated MAPK cascade | 44/2311 | 192/18723 | 3.09e-05 | 5.10e-04 | 44 |
GO:00076238 | Cervix | CC | circadian rhythm | 46/2311 | 210/18723 | 6.76e-05 | 9.60e-04 | 46 |
GO:00380664 | Cervix | CC | p38MAPK cascade | 17/2311 | 55/18723 | 2.25e-04 | 2.54e-03 | 17 |
GO:00518964 | Cervix | CC | regulation of protein kinase B signaling | 39/2311 | 185/18723 | 5.25e-04 | 5.10e-03 | 39 |
GO:00434913 | Cervix | CC | protein kinase B signaling | 43/2311 | 211/18723 | 5.95e-04 | 5.60e-03 | 43 |
GO:00072545 | Cervix | CC | JNK cascade | 35/2311 | 167/18723 | 1.10e-03 | 9.09e-03 | 35 |
GO:19007442 | Cervix | CC | regulation of p38MAPK cascade | 14/2311 | 47/18723 | 1.18e-03 | 9.56e-03 | 14 |
GO:00163117 | Cervix | CC | dephosphorylation | 73/2311 | 417/18723 | 1.23e-03 | 9.87e-03 | 73 |
GO:00463285 | Cervix | CC | regulation of JNK cascade | 28/2311 | 133/18723 | 3.06e-03 | 2.01e-02 | 28 |
GO:0002507 | Cervix | CC | tolerance induction | 9/2311 | 28/18723 | 5.02e-03 | 2.98e-02 | 9 |
GO:0007623 | Colorectum | AD | circadian rhythm | 72/3918 | 210/18723 | 4.50e-06 | 1.21e-04 | 72 |
GO:0048511 | Colorectum | AD | rhythmic process | 94/3918 | 298/18723 | 1.00e-05 | 2.34e-04 | 94 |
GO:0016311 | Colorectum | AD | dephosphorylation | 123/3918 | 417/18723 | 1.84e-05 | 3.82e-04 | 123 |
GO:0006470 | Colorectum | AD | protein dephosphorylation | 88/3918 | 281/18723 | 2.56e-05 | 4.89e-04 | 88 |
GO:0051403 | Colorectum | AD | stress-activated MAPK cascade | 72/3918 | 239/18723 | 4.77e-04 | 5.25e-03 | 72 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04151 | Colorectum | FAP | PI3K-Akt signaling pathway | 75/1404 | 354/8465 | 1.23e-02 | 4.19e-02 | 2.55e-02 | 75 |
hsa041511 | Colorectum | FAP | PI3K-Akt signaling pathway | 75/1404 | 354/8465 | 1.23e-02 | 4.19e-02 | 2.55e-02 | 75 |
hsa041512 | Colorectum | CRC | PI3K-Akt signaling pathway | 64/1091 | 354/8465 | 2.70e-03 | 1.77e-02 | 1.20e-02 | 64 |
hsa041513 | Colorectum | CRC | PI3K-Akt signaling pathway | 64/1091 | 354/8465 | 2.70e-03 | 1.77e-02 | 1.20e-02 | 64 |
hsa041514 | Lung | IAC | PI3K-Akt signaling pathway | 60/1053 | 354/8465 | 7.03e-03 | 2.86e-02 | 1.90e-02 | 60 |
hsa0415111 | Lung | IAC | PI3K-Akt signaling pathway | 60/1053 | 354/8465 | 7.03e-03 | 2.86e-02 | 1.90e-02 | 60 |
hsa0415121 | Lung | AIS | PI3K-Akt signaling pathway | 57/961 | 354/8465 | 3.72e-03 | 2.00e-02 | 1.28e-02 | 57 |
hsa0415131 | Lung | AIS | PI3K-Akt signaling pathway | 57/961 | 354/8465 | 3.72e-03 | 2.00e-02 | 1.28e-02 | 57 |
hsa041515 | Prostate | BPH | PI3K-Akt signaling pathway | 104/1718 | 354/8465 | 2.07e-05 | 1.55e-04 | 9.61e-05 | 104 |
hsa0415112 | Prostate | BPH | PI3K-Akt signaling pathway | 104/1718 | 354/8465 | 2.07e-05 | 1.55e-04 | 9.61e-05 | 104 |
hsa0415122 | Prostate | Tumor | PI3K-Akt signaling pathway | 105/1791 | 354/8465 | 7.42e-05 | 5.30e-04 | 3.28e-04 | 105 |
hsa0415132 | Prostate | Tumor | PI3K-Akt signaling pathway | 105/1791 | 354/8465 | 7.42e-05 | 5.30e-04 | 3.28e-04 | 105 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHLPP1 | SNV | Missense_Mutation | c.3027N>C | p.Glu1009Asp | p.E1009D | O60346 | protein_coding | tolerated(0.32) | benign(0.034) | TCGA-43-5668-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Other, specify in notesMAGE3-AS15-NSC-003 | clinical | PD | |
PHLPP1 | SNV | Missense_Mutation | novel | c.4975N>T | p.Asp1659Tyr | p.D1659Y | O60346 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-66-2782-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unspecific | PD | |
PHLPP1 | SNV | Missense_Mutation | novel | c.3826N>C | p.Asp1276His | p.D1276H | O60346 | protein_coding | deleterious(0.02) | probably_damaging(0.983) | TCGA-CR-6472-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
PHLPP1 | SNV | Missense_Mutation | novel | c.3134N>G | p.Tyr1045Cys | p.Y1045C | O60346 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-F7-A61S-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
PHLPP1 | SNV | Missense_Mutation | rs569551998 | c.4543N>T | p.Arg1515Cys | p.R1515C | O60346 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PHLPP1 | SNV | Missense_Mutation | novel | c.4874N>A | p.Gly1625Asp | p.G1625D | O60346 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PHLPP1 | SNV | Missense_Mutation | novel | c.2828N>A | p.Arg943Gln | p.R943Q | O60346 | protein_coding | deleterious(0.04) | probably_damaging(0.992) | TCGA-B7-A5TJ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PHLPP1 | SNV | Missense_Mutation | c.3500C>T | p.Ala1167Val | p.A1167V | O60346 | protein_coding | tolerated(0.11) | possibly_damaging(0.471) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PHLPP1 | SNV | Missense_Mutation | c.4196C>T | p.Ala1399Val | p.A1399V | O60346 | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PHLPP1 | SNV | Missense_Mutation | rs201439333 | c.4496N>T | p.Pro1499Leu | p.P1499L | O60346 | protein_coding | deleterious(0) | benign(0.098) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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