![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PDS5A |
Gene summary for PDS5A |
![]() |
Gene information | Species | Human | Gene symbol | PDS5A | Gene ID | 23244 |
Gene name | PDS5 cohesin associated factor A | |
Gene Alias | PIG54 | |
Cytomap | 4p14 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | G1UI16 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23244 | PDS5A | CCI_1 | Human | Cervix | CC | 3.00e-03 | 7.22e-01 | 0.528 |
23244 | PDS5A | CCI_2 | Human | Cervix | CC | 5.54e-09 | 9.30e-01 | 0.5249 |
23244 | PDS5A | CCI_3 | Human | Cervix | CC | 7.84e-05 | 5.57e-01 | 0.516 |
23244 | PDS5A | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.61e-05 | -3.07e-01 | 0.0155 |
23244 | PDS5A | HTA11_347_2000001011 | Human | Colorectum | AD | 2.16e-09 | 5.74e-01 | -0.1954 |
23244 | PDS5A | F007 | Human | Colorectum | FAP | 5.91e-04 | -2.90e-01 | 0.1176 |
23244 | PDS5A | A001-C-207 | Human | Colorectum | FAP | 8.51e-04 | -2.44e-01 | 0.1278 |
23244 | PDS5A | A015-C-203 | Human | Colorectum | FAP | 8.23e-37 | -5.10e-01 | -0.1294 |
23244 | PDS5A | A015-C-204 | Human | Colorectum | FAP | 2.29e-09 | -3.96e-01 | -0.0228 |
23244 | PDS5A | A014-C-040 | Human | Colorectum | FAP | 5.45e-07 | -4.90e-01 | -0.1184 |
23244 | PDS5A | A002-C-201 | Human | Colorectum | FAP | 9.92e-17 | -4.08e-01 | 0.0324 |
23244 | PDS5A | A002-C-203 | Human | Colorectum | FAP | 2.04e-05 | -2.26e-01 | 0.2786 |
23244 | PDS5A | A001-C-119 | Human | Colorectum | FAP | 9.54e-09 | -3.79e-01 | -0.1557 |
23244 | PDS5A | A001-C-108 | Human | Colorectum | FAP | 2.29e-18 | -3.05e-01 | -0.0272 |
23244 | PDS5A | A002-C-205 | Human | Colorectum | FAP | 4.37e-30 | -5.26e-01 | -0.1236 |
23244 | PDS5A | A001-C-104 | Human | Colorectum | FAP | 3.65e-04 | -2.04e-01 | 0.0184 |
23244 | PDS5A | A015-C-005 | Human | Colorectum | FAP | 1.57e-06 | -3.72e-01 | -0.0336 |
23244 | PDS5A | A015-C-006 | Human | Colorectum | FAP | 2.03e-21 | -5.80e-01 | -0.0994 |
23244 | PDS5A | A015-C-106 | Human | Colorectum | FAP | 2.96e-12 | -2.78e-01 | -0.0511 |
23244 | PDS5A | A002-C-114 | Human | Colorectum | FAP | 5.17e-25 | -4.87e-01 | -0.1561 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070646 | Cervix | CC | mitotic sister chromatid cohesion | 12/2311 | 28/18723 | 5.47e-05 | 8.06e-04 | 12 |
GO:00062602 | Cervix | CC | DNA replication | 48/2311 | 260/18723 | 2.70e-03 | 1.85e-02 | 48 |
GO:01400143 | Cervix | CC | mitotic nuclear division | 50/2311 | 287/18723 | 7.27e-03 | 3.91e-02 | 50 |
GO:00070625 | Cervix | CC | sister chromatid cohesion | 15/2311 | 62/18723 | 7.30e-03 | 3.92e-02 | 15 |
GO:00482851 | Cervix | CC | organelle fission | 78/2311 | 488/18723 | 9.70e-03 | 4.79e-02 | 78 |
GO:0007064 | Colorectum | AD | mitotic sister chromatid cohesion | 13/3918 | 28/18723 | 2.22e-03 | 1.75e-02 | 13 |
GO:0007062 | Colorectum | AD | sister chromatid cohesion | 23/3918 | 62/18723 | 2.51e-03 | 1.92e-02 | 23 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
GO:00070642 | Colorectum | FAP | mitotic sister chromatid cohesion | 11/2622 | 28/18723 | 8.55e-04 | 8.79e-03 | 11 |
GO:00070622 | Colorectum | FAP | sister chromatid cohesion | 18/2622 | 62/18723 | 1.60e-03 | 1.42e-02 | 18 |
GO:00070623 | Colorectum | CRC | sister chromatid cohesion | 16/2078 | 62/18723 | 9.40e-04 | 1.15e-02 | 16 |
GO:00070643 | Colorectum | CRC | mitotic sister chromatid cohesion | 9/2078 | 28/18723 | 2.43e-03 | 2.30e-02 | 9 |
GO:0006275 | Colorectum | CRC | regulation of DNA replication | 21/2078 | 107/18723 | 6.56e-03 | 4.70e-02 | 21 |
GO:00062752 | Endometrium | AEH | regulation of DNA replication | 21/2100 | 107/18723 | 7.38e-03 | 4.20e-02 | 21 |
GO:000627511 | Endometrium | EEC | regulation of DNA replication | 22/2168 | 107/18723 | 5.09e-03 | 3.20e-02 | 22 |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
Page: 1 2 3 4 5 6 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041106 | Cervix | CC | Cell cycle | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa0411013 | Cervix | CC | Cell cycle | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa04110 | Colorectum | FAP | Cell cycle | 37/1404 | 157/8465 | 1.44e-02 | 4.77e-02 | 2.90e-02 | 37 |
hsa041101 | Colorectum | FAP | Cell cycle | 37/1404 | 157/8465 | 1.44e-02 | 4.77e-02 | 2.90e-02 | 37 |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa041104 | Liver | Cirrhotic | Cell cycle | 61/2530 | 157/8465 | 9.53e-03 | 3.21e-02 | 1.98e-02 | 61 |
hsa0411011 | Liver | Cirrhotic | Cell cycle | 61/2530 | 157/8465 | 9.53e-03 | 3.21e-02 | 1.98e-02 | 61 |
hsa041102 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa041103 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa041105 | Lung | IAC | Cell cycle | 30/1053 | 157/8465 | 1.03e-02 | 3.83e-02 | 2.54e-02 | 30 |
hsa0411012 | Lung | IAC | Cell cycle | 30/1053 | 157/8465 | 1.03e-02 | 3.83e-02 | 2.54e-02 | 30 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0411022 | Oral cavity | LP | Cell cycle | 70/2418 | 157/8465 | 1.17e-05 | 8.27e-05 | 5.33e-05 | 70 |
hsa0411032 | Oral cavity | LP | Cell cycle | 70/2418 | 157/8465 | 1.17e-05 | 8.27e-05 | 5.33e-05 | 70 |
hsa0411041 | Oral cavity | EOLP | Cell cycle | 42/1218 | 157/8465 | 3.20e-05 | 1.61e-04 | 9.52e-05 | 42 |
hsa0411051 | Oral cavity | EOLP | Cell cycle | 42/1218 | 157/8465 | 3.20e-05 | 1.61e-04 | 9.52e-05 | 42 |
hsa0411061 | Oral cavity | NEOLP | Cell cycle | 37/1112 | 157/8465 | 2.29e-04 | 1.58e-03 | 9.95e-04 | 37 |
hsa0411071 | Oral cavity | NEOLP | Cell cycle | 37/1112 | 157/8465 | 2.29e-04 | 1.58e-03 | 9.95e-04 | 37 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDS5A | SNV | Missense_Mutation | c.1126N>G | p.Ile376Val | p.I376V | Q29RF7 | protein_coding | tolerated(1) | benign(0.047) | TCGA-CV-7089-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PDS5A | SNV | Missense_Mutation | novel | c.2045N>A | p.Ser682Tyr | p.S682Y | Q29RF7 | protein_coding | tolerated(0.4) | probably_damaging(0.991) | TCGA-CV-A6JN-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PDS5A | SNV | Missense_Mutation | novel | c.260N>A | p.Arg87His | p.R87H | Q29RF7 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-CV-A6K1-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PDS5A | SNV | Missense_Mutation | novel | c.595N>A | p.Asp199Asn | p.D199N | Q29RF7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D6-A74Q-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDS5A | SNV | Missense_Mutation | novel | c.23N>G | p.Lys8Arg | p.K8R | Q29RF7 | protein_coding | tolerated_low_confidence(0.25) | benign(0.006) | TCGA-VN-A88I-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Unknown | Unknown | SD |
PDS5A | SNV | Missense_Mutation | novel | c.3089N>A | p.Cys1030Tyr | p.C1030Y | Q29RF7 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PDS5A | insertion | Frame_Shift_Ins | novel | c.2143dupC | p.Gln715ProfsTer36 | p.Q715Pfs*36 | Q29RF7 | protein_coding | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | ||
PDS5A | SNV | Missense_Mutation | novel | c.242N>C | p.Asn81Thr | p.N81T | Q29RF7 | protein_coding | deleterious(0) | possibly_damaging(0.614) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDS5A | SNV | Missense_Mutation | c.3611T>G | p.Ile1204Ser | p.I1204S | Q29RF7 | protein_coding | tolerated_low_confidence(0.52) | benign(0) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PDS5A | SNV | Missense_Mutation | c.3011A>G | p.Tyr1004Cys | p.Y1004C | Q29RF7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |