GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000915013 | Lung | AIS | purine ribonucleotide metabolic process | 58/1849 | 368/18723 | 2.33e-04 | 4.68e-03 | 58 |
GO:000925913 | Lung | AIS | ribonucleotide metabolic process | 59/1849 | 385/18723 | 4.36e-04 | 7.41e-03 | 59 |
GO:000616313 | Lung | AIS | purine nucleotide metabolic process | 59/1849 | 396/18723 | 8.91e-04 | 1.20e-02 | 59 |
GO:001969313 | Lung | AIS | ribose phosphate metabolic process | 59/1849 | 396/18723 | 8.91e-04 | 1.20e-02 | 59 |
GO:007252113 | Lung | AIS | purine-containing compound metabolic process | 61/1849 | 416/18723 | 1.10e-03 | 1.42e-02 | 61 |
GO:003465524 | Thyroid | HT | nucleobase-containing compound catabolic process | 45/1272 | 407/18723 | 8.67e-04 | 9.20e-03 | 45 |
GO:004670020 | Thyroid | HT | heterocycle catabolic process | 47/1272 | 445/18723 | 1.76e-03 | 1.58e-02 | 47 |
GO:001943920 | Thyroid | HT | aromatic compound catabolic process | 48/1272 | 467/18723 | 2.74e-03 | 2.25e-02 | 48 |
GO:190136120 | Thyroid | HT | organic cyclic compound catabolic process | 50/1272 | 495/18723 | 3.22e-03 | 2.55e-02 | 50 |
GO:004427024 | Thyroid | HT | cellular nitrogen compound catabolic process | 46/1272 | 451/18723 | 3.83e-03 | 2.84e-02 | 46 |
GO:0034655112 | Thyroid | PTC | nucleobase-containing compound catabolic process | 211/5968 | 407/18723 | 2.72e-17 | 2.52e-15 | 211 |
GO:0046700111 | Thyroid | PTC | heterocycle catabolic process | 221/5968 | 445/18723 | 2.43e-15 | 1.72e-13 | 221 |
GO:0044270111 | Thyroid | PTC | cellular nitrogen compound catabolic process | 223/5968 | 451/18723 | 3.34e-15 | 2.31e-13 | 223 |
GO:0019439111 | Thyroid | PTC | aromatic compound catabolic process | 225/5968 | 467/18723 | 8.51e-14 | 4.71e-12 | 225 |
GO:1901361111 | Thyroid | PTC | organic cyclic compound catabolic process | 231/5968 | 495/18723 | 2.55e-12 | 1.12e-10 | 231 |
GO:001969327 | Thyroid | PTC | ribose phosphate metabolic process | 176/5968 | 396/18723 | 8.28e-08 | 1.70e-06 | 176 |
GO:000915028 | Thyroid | PTC | purine ribonucleotide metabolic process | 165/5968 | 368/18723 | 1.03e-07 | 2.05e-06 | 165 |
GO:007252127 | Thyroid | PTC | purine-containing compound metabolic process | 182/5968 | 416/18723 | 1.92e-07 | 3.51e-06 | 182 |
GO:000925927 | Thyroid | PTC | ribonucleotide metabolic process | 170/5968 | 385/18723 | 2.32e-07 | 4.08e-06 | 170 |
GO:000616327 | Thyroid | PTC | purine nucleotide metabolic process | 170/5968 | 396/18723 | 2.02e-06 | 2.75e-05 | 170 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDE8B | SNV | Missense_Mutation | novel | c.568T>G | p.Phe190Val | p.F190V | O95263 | protein_coding | tolerated(0.07) | possibly_damaging(0.491) | TCGA-85-8481-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDE8B | SNV | Missense_Mutation | novel | c.1981N>A | p.Gly661Arg | p.G661R | O95263 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDE8B | SNV | Missense_Mutation | novel | c.93N>G | p.Ser31Arg | p.S31R | O95263 | protein_coding | tolerated_low_confidence(0.37) | benign(0.18) | TCGA-94-A5I6-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
PDE8B | SNV | Missense_Mutation | novel | c.2611C>A | p.Leu871Ile | p.L871I | O95263 | protein_coding | deleterious(0.01) | possibly_damaging(0.686) | TCGA-96-7544-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDE8B | SNV | Missense_Mutation | | c.517C>G | p.Leu173Val | p.L173V | O95263 | protein_coding | tolerated(0.05) | probably_damaging(0.909) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PDE8B | SNV | Missense_Mutation | novel | c.1481C>T | p.Thr494Ile | p.T494I | O95263 | protein_coding | tolerated(0.12) | benign(0.206) | TCGA-98-A538-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDE8B | SNV | Missense_Mutation | novel | c.1727N>A | p.Leu576Gln | p.L576Q | O95263 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BA-A4II-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
PDE8B | SNV | Missense_Mutation | novel | c.1319N>A | p.Ser440Tyr | p.S440Y | O95263 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-BA-A6DA-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PDE8B | SNV | Missense_Mutation | novel | c.1435N>G | p.Leu479Val | p.L479V | O95263 | protein_coding | deleterious(0.04) | possibly_damaging(0.831) | TCGA-CN-6998-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
PDE8B | SNV | Missense_Mutation | novel | c.2248G>A | p.Glu750Lys | p.E750K | O95263 | protein_coding | tolerated(0.86) | benign(0.062) | TCGA-CR-6472-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |