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Gene: PCNX4 |
Gene summary for PCNX4 |
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Gene information | Species | Human | Gene symbol | PCNX4 | Gene ID | 64430 |
Gene name | pecanex 4 | |
Gene Alias | C14orf135 | |
Cytomap | 14q23.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q63HM2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64430 | PCNX4 | RNA-P17T-P17T-2 | Human | Lung | IAC | 4.30e-05 | 5.08e-01 | 0.3371 |
64430 | PCNX4 | RNA-P17T-P17T-4 | Human | Lung | IAC | 7.92e-03 | 3.25e-01 | 0.343 |
64430 | PCNX4 | RNA-P17T-P17T-8 | Human | Lung | IAC | 1.46e-09 | 6.06e-01 | 0.3329 |
64430 | PCNX4 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 3.26e-05 | 7.70e-01 | -0.0263 |
64430 | PCNX4 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.99e-06 | 2.76e-01 | -0.0166 |
64430 | PCNX4 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 3.12e-08 | 3.17e-01 | -0.0132 |
64430 | PCNX4 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.97e-09 | 3.15e-01 | -0.013 |
64430 | PCNX4 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 2.00e-02 | 2.34e-01 | -0.0121 |
64430 | PCNX4 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 1.78e-02 | 3.66e-01 | -0.0809 |
64430 | PCNX4 | HTA12-15-2 | Human | Pancreas | PDAC | 7.26e-07 | 6.06e-01 | 0.2315 |
64430 | PCNX4 | HTA12-23-1 | Human | Pancreas | PDAC | 2.07e-02 | 5.65e-01 | 0.3405 |
64430 | PCNX4 | HTA12-26-1 | Human | Pancreas | PDAC | 9.38e-10 | 6.57e-01 | 0.3728 |
64430 | PCNX4 | HTA12-29-1 | Human | Pancreas | PDAC | 4.10e-25 | 6.74e-01 | 0.3722 |
64430 | PCNX4 | male-WTA | Human | Thyroid | PTC | 1.41e-16 | 1.22e-01 | 0.1037 |
64430 | PCNX4 | PTC01 | Human | Thyroid | PTC | 2.67e-08 | 1.11e-01 | 0.1899 |
64430 | PCNX4 | PTC04 | Human | Thyroid | PTC | 3.24e-13 | 2.79e-01 | 0.1927 |
64430 | PCNX4 | PTC05 | Human | Thyroid | PTC | 2.01e-10 | 3.59e-01 | 0.2065 |
64430 | PCNX4 | PTC06 | Human | Thyroid | PTC | 1.72e-13 | 4.01e-01 | 0.2057 |
64430 | PCNX4 | PTC07 | Human | Thyroid | PTC | 3.21e-16 | 3.79e-01 | 0.2044 |
64430 | PCNX4 | ATC09 | Human | Thyroid | ATC | 8.87e-17 | 4.13e-01 | 0.2871 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCNX4 | SNV | Missense_Mutation | novel | c.421G>C | p.Val141Leu | p.V141L | Q63HM2 | protein_coding | tolerated(0.14) | benign(0.013) | TCGA-44-3398-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCNX4 | SNV | Missense_Mutation | novel | c.1684N>C | p.Thr562Pro | p.T562P | Q63HM2 | protein_coding | deleterious(0) | benign(0.368) | TCGA-44-4112-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
PCNX4 | SNV | Missense_Mutation | c.1598N>T | p.Arg533Leu | p.R533L | Q63HM2 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-53-7624-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
PCNX4 | SNV | Missense_Mutation | c.2759N>A | p.Cys920Tyr | p.C920Y | Q63HM2 | protein_coding | tolerated(0.69) | benign(0.001) | TCGA-55-5899-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
PCNX4 | SNV | Missense_Mutation | c.1049N>T | p.His350Leu | p.H350L | Q63HM2 | protein_coding | tolerated(0.57) | benign(0) | TCGA-69-7978-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PCNX4 | SNV | Missense_Mutation | c.232N>A | p.Gly78Arg | p.G78R | Q63HM2 | protein_coding | deleterious(0.01) | probably_damaging(0.92) | TCGA-80-5611-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | SD | |
PCNX4 | SNV | Missense_Mutation | c.583N>G | p.Thr195Ala | p.T195A | Q63HM2 | protein_coding | tolerated(0.09) | benign(0.303) | TCGA-97-7937-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PCNX4 | SNV | Missense_Mutation | novel | c.1717T>A | p.Ser573Thr | p.S573T | Q63HM2 | protein_coding | tolerated(0.14) | benign(0.026) | TCGA-NJ-A4YF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCNX4 | SNV | Missense_Mutation | c.865N>G | p.Leu289Val | p.L289V | Q63HM2 | protein_coding | tolerated(0.13) | benign(0.086) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PCNX4 | SNV | Missense_Mutation | novel | c.853N>T | p.Met285Leu | p.M285L | Q63HM2 | protein_coding | deleterious(0.03) | benign(0.437) | TCGA-22-4596-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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