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Gene: OSMR |
Gene summary for OSMR |
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Gene information | Species | Human | Gene symbol | OSMR | Gene ID | 9180 |
Gene name | oncostatin M receptor | |
Gene Alias | IL-31R-beta | |
Cytomap | 5p13.1 | |
Gene Type | protein-coding | GO ID | GO:0002526 | UniProtAcc | Q99650 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9180 | OSMR | CA_HPV_1 | Human | Cervix | CC | 6.60e-03 | -1.49e-01 | 0.0264 |
9180 | OSMR | CCI_1 | Human | Cervix | CC | 7.52e-08 | 8.81e-01 | 0.528 |
9180 | OSMR | CCI_3 | Human | Cervix | CC | 2.18e-04 | 6.90e-01 | 0.516 |
9180 | OSMR | Tumor | Human | Cervix | CC | 4.90e-05 | 2.69e-01 | 0.1241 |
9180 | OSMR | sample3 | Human | Cervix | CC | 5.93e-19 | 4.16e-01 | 0.1387 |
9180 | OSMR | T3 | Human | Cervix | CC | 1.14e-15 | 4.16e-01 | 0.1389 |
9180 | OSMR | LZE2D | Human | Esophagus | HGIN | 7.66e-03 | 1.80e-01 | 0.0642 |
9180 | OSMR | LZE4T | Human | Esophagus | ESCC | 5.13e-05 | 2.42e-01 | 0.0811 |
9180 | OSMR | LZE8T | Human | Esophagus | ESCC | 1.13e-04 | 2.90e-01 | 0.067 |
9180 | OSMR | LZE20T | Human | Esophagus | ESCC | 4.34e-03 | 2.56e-01 | 0.0662 |
9180 | OSMR | LZE24T | Human | Esophagus | ESCC | 5.75e-05 | -2.10e-02 | 0.0596 |
9180 | OSMR | P1T-E | Human | Esophagus | ESCC | 1.47e-03 | 2.00e-01 | 0.0875 |
9180 | OSMR | P2T-E | Human | Esophagus | ESCC | 1.67e-12 | 8.95e-02 | 0.1177 |
9180 | OSMR | P4T-E | Human | Esophagus | ESCC | 2.16e-06 | -8.94e-03 | 0.1323 |
9180 | OSMR | P5T-E | Human | Esophagus | ESCC | 7.49e-18 | 2.42e-01 | 0.1327 |
9180 | OSMR | P8T-E | Human | Esophagus | ESCC | 2.17e-12 | 3.13e-01 | 0.0889 |
9180 | OSMR | P9T-E | Human | Esophagus | ESCC | 1.66e-17 | 4.18e-01 | 0.1131 |
9180 | OSMR | P10T-E | Human | Esophagus | ESCC | 1.73e-16 | 1.85e-01 | 0.116 |
9180 | OSMR | P11T-E | Human | Esophagus | ESCC | 4.32e-04 | 3.83e-02 | 0.1426 |
9180 | OSMR | P12T-E | Human | Esophagus | ESCC | 2.95e-10 | 2.23e-02 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00321035 | Cervix | CC | positive regulation of response to external stimulus | 95/2311 | 427/18723 | 5.44e-09 | 5.03e-07 | 95 |
GO:00313494 | Cervix | CC | positive regulation of defense response | 60/2311 | 278/18723 | 9.38e-06 | 2.11e-04 | 60 |
GO:00507273 | Cervix | CC | regulation of inflammatory response | 75/2311 | 386/18723 | 3.95e-05 | 6.18e-04 | 75 |
GO:00507294 | Cervix | CC | positive regulation of inflammatory response | 34/2311 | 142/18723 | 9.51e-05 | 1.25e-03 | 34 |
GO:00192213 | Cervix | CC | cytokine-mediated signaling pathway | 84/2311 | 472/18723 | 3.25e-04 | 3.44e-03 | 84 |
GO:0002526 | Liver | NAFLD | acute inflammatory response | 26/1882 | 112/18723 | 3.68e-05 | 9.23e-04 | 26 |
GO:00025262 | Liver | HCC | acute inflammatory response | 62/7958 | 112/18723 | 4.06e-03 | 1.77e-02 | 62 |
GO:00321037 | Oral cavity | OSCC | positive regulation of response to external stimulus | 203/7305 | 427/18723 | 1.79e-04 | 1.22e-03 | 203 |
GO:00192214 | Oral cavity | OSCC | cytokine-mediated signaling pathway | 222/7305 | 472/18723 | 2.02e-04 | 1.35e-03 | 222 |
GO:00313495 | Oral cavity | OSCC | positive regulation of defense response | 127/7305 | 278/18723 | 1.32e-02 | 4.39e-02 | 127 |
GO:001922112 | Oral cavity | EOLP | cytokine-mediated signaling pathway | 94/2218 | 472/18723 | 2.36e-07 | 7.37e-06 | 94 |
GO:003210314 | Oral cavity | EOLP | positive regulation of response to external stimulus | 84/2218 | 427/18723 | 1.72e-06 | 3.99e-05 | 84 |
GO:003134912 | Oral cavity | EOLP | positive regulation of defense response | 53/2218 | 278/18723 | 3.00e-04 | 2.81e-03 | 53 |
GO:00507274 | Oral cavity | EOLP | regulation of inflammatory response | 66/2218 | 386/18723 | 1.34e-03 | 9.33e-03 | 66 |
GO:001922122 | Oral cavity | NEOLP | cytokine-mediated signaling pathway | 88/2005 | 472/18723 | 1.37e-07 | 4.80e-06 | 88 |
GO:003210323 | Oral cavity | NEOLP | positive regulation of response to external stimulus | 81/2005 | 427/18723 | 2.04e-07 | 6.74e-06 | 81 |
GO:003134922 | Oral cavity | NEOLP | positive regulation of defense response | 47/2005 | 278/18723 | 1.05e-03 | 7.99e-03 | 47 |
GO:00025265 | Oral cavity | NEOLP | acute inflammatory response | 23/2005 | 112/18723 | 1.59e-03 | 1.11e-02 | 23 |
GO:005072712 | Oral cavity | NEOLP | regulation of inflammatory response | 60/2005 | 386/18723 | 1.99e-03 | 1.33e-02 | 60 |
GO:00507295 | Oral cavity | NEOLP | positive regulation of inflammatory response | 25/2005 | 142/18723 | 8.58e-03 | 4.15e-02 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0415114 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa041516 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
hsa0415113 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
hsa0415123 | Oral cavity | EOLP | PI3K-Akt signaling pathway | 73/1218 | 354/8465 | 7.03e-04 | 2.69e-03 | 1.59e-03 | 73 |
hsa04630 | Oral cavity | EOLP | JAK-STAT signaling pathway | 35/1218 | 166/8465 | 1.15e-02 | 3.07e-02 | 1.81e-02 | 35 |
hsa0415133 | Oral cavity | EOLP | PI3K-Akt signaling pathway | 73/1218 | 354/8465 | 7.03e-04 | 2.69e-03 | 1.59e-03 | 73 |
hsa046301 | Oral cavity | EOLP | JAK-STAT signaling pathway | 35/1218 | 166/8465 | 1.15e-02 | 3.07e-02 | 1.81e-02 | 35 |
hsa0415141 | Oral cavity | NEOLP | PI3K-Akt signaling pathway | 79/1112 | 354/8465 | 8.42e-07 | 9.92e-06 | 6.24e-06 | 79 |
hsa0415151 | Oral cavity | NEOLP | PI3K-Akt signaling pathway | 79/1112 | 354/8465 | 8.42e-07 | 9.92e-06 | 6.24e-06 | 79 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Breast | DCIS |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Breast | Healthy |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Cervix | CC |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Cervix | Healthy |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Cervix | Precancer |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Endometrium | ADJ |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Endometrium | AEH |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Endometrium | EEC |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Endometrium | Healthy |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Esophagus | ESCC |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | HNSCC | Healthy |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | HNSCC | OSCC |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Liver | HCC |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Lung | AAH |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Lung | AIS |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Lung | IAC |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Lung | Precancer |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Prostate | ADJ |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Prostate | BPH |
OSM | OSMR_IL6ST | OSM_OSMR_IL6ST | OSM | Skin | ADJ |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OSMR | SNV | Missense_Mutation | c.2139N>G | p.Phe713Leu | p.F713L | Q99650 | protein_coding | tolerated(1) | benign(0) | TCGA-P3-A6T5-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
OSMR | SNV | Missense_Mutation | novel | c.2752N>A | p.Val918Met | p.V918M | Q99650 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
OSMR | SNV | Missense_Mutation | rs147223683 | c.134G>A | p.Arg45His | p.R45H | Q99650 | protein_coding | tolerated(0.56) | benign(0) | TCGA-BR-8588-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OSMR | SNV | Missense_Mutation | c.2038N>A | p.Leu680Ile | p.L680I | Q99650 | protein_coding | deleterious(0.03) | possibly_damaging(0.494) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
OSMR | SNV | Missense_Mutation | c.811N>A | p.Pro271Thr | p.P271T | Q99650 | protein_coding | tolerated(0.69) | benign(0.15) | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR | |
OSMR | SNV | Missense_Mutation | rs377012343 | c.1891N>A | p.Val631Met | p.V631M | Q99650 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
OSMR | SNV | Missense_Mutation | rs372089425 | c.131N>T | p.Thr44Met | p.T44M | Q99650 | protein_coding | deleterious(0.02) | benign(0.197) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
OSMR | SNV | Missense_Mutation | novel | c.326N>T | p.Thr109Ile | p.T109I | Q99650 | protein_coding | tolerated(0.06) | benign(0.028) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
OSMR | SNV | Missense_Mutation | novel | c.1296N>T | p.Glu432Asp | p.E432D | Q99650 | protein_coding | tolerated(0.45) | benign(0.003) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
OSMR | deletion | Frame_Shift_Del | c.1849delA | p.Thr617GlnfsTer20 | p.T617Qfs*20 | Q99650 | protein_coding | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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