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Gene: NUP107 |
Gene summary for NUP107 |
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Gene information | Species | Human | Gene symbol | NUP107 | Gene ID | 57122 |
Gene name | nucleoporin 107 | |
Gene Alias | NPHS11 | |
Cytomap | 12q15 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P57740 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57122 | NUP107 | CCI_2 | Human | Cervix | CC | 3.66e-05 | 5.58e-01 | 0.5249 |
57122 | NUP107 | CCI_3 | Human | Cervix | CC | 5.21e-08 | 7.04e-01 | 0.516 |
57122 | NUP107 | T3 | Human | Cervix | CC | 1.78e-03 | 1.85e-01 | 0.1389 |
57122 | NUP107 | LZE4T | Human | Esophagus | ESCC | 9.32e-14 | 3.29e-01 | 0.0811 |
57122 | NUP107 | LZE7T | Human | Esophagus | ESCC | 5.22e-09 | 4.29e-01 | 0.0667 |
57122 | NUP107 | LZE20T | Human | Esophagus | ESCC | 4.64e-02 | 1.31e-01 | 0.0662 |
57122 | NUP107 | LZE22T | Human | Esophagus | ESCC | 2.88e-05 | 2.86e-01 | 0.068 |
57122 | NUP107 | LZE24T | Human | Esophagus | ESCC | 1.87e-16 | 2.72e-01 | 0.0596 |
57122 | NUP107 | LZE6T | Human | Esophagus | ESCC | 2.47e-03 | 2.19e-01 | 0.0845 |
57122 | NUP107 | P1T-E | Human | Esophagus | ESCC | 3.45e-08 | 4.79e-01 | 0.0875 |
57122 | NUP107 | P2T-E | Human | Esophagus | ESCC | 1.52e-55 | 9.99e-01 | 0.1177 |
57122 | NUP107 | P4T-E | Human | Esophagus | ESCC | 1.26e-12 | 3.27e-01 | 0.1323 |
57122 | NUP107 | P5T-E | Human | Esophagus | ESCC | 2.68e-17 | 4.63e-01 | 0.1327 |
57122 | NUP107 | P8T-E | Human | Esophagus | ESCC | 1.46e-40 | 6.62e-01 | 0.0889 |
57122 | NUP107 | P9T-E | Human | Esophagus | ESCC | 2.97e-07 | 1.38e-01 | 0.1131 |
57122 | NUP107 | P10T-E | Human | Esophagus | ESCC | 3.34e-20 | 3.15e-01 | 0.116 |
57122 | NUP107 | P11T-E | Human | Esophagus | ESCC | 1.37e-06 | 3.12e-01 | 0.1426 |
57122 | NUP107 | P12T-E | Human | Esophagus | ESCC | 3.50e-34 | 6.89e-01 | 0.1122 |
57122 | NUP107 | P15T-E | Human | Esophagus | ESCC | 2.75e-17 | 3.24e-01 | 0.1149 |
57122 | NUP107 | P16T-E | Human | Esophagus | ESCC | 3.31e-36 | 5.58e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00725949 | Cervix | CC | establishment of protein localization to organelle | 99/2311 | 422/18723 | 1.23e-10 | 2.11e-08 | 99 |
GO:00069139 | Cervix | CC | nucleocytoplasmic transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00511699 | Cervix | CC | nuclear transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:00614588 | Cervix | CC | reproductive system development | 87/2311 | 427/18723 | 1.37e-06 | 4.55e-05 | 87 |
GO:00486088 | Cervix | CC | reproductive structure development | 86/2311 | 424/18723 | 1.90e-06 | 5.97e-05 | 86 |
GO:00170388 | Cervix | CC | protein import | 48/2311 | 206/18723 | 8.62e-06 | 1.98e-04 | 48 |
GO:00511689 | Cervix | CC | nuclear export | 38/2311 | 154/18723 | 1.86e-05 | 3.46e-04 | 38 |
GO:00511707 | Cervix | CC | import into nucleus | 38/2311 | 159/18723 | 3.98e-05 | 6.18e-04 | 38 |
GO:00512368 | Cervix | CC | establishment of RNA localization | 39/2311 | 166/18723 | 4.76e-05 | 7.25e-04 | 39 |
GO:00066067 | Cervix | CC | protein import into nucleus | 37/2311 | 155/18723 | 5.13e-05 | 7.71e-04 | 37 |
GO:00506578 | Cervix | CC | nucleic acid transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:00506588 | Cervix | CC | RNA transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:000640310 | Cervix | CC | RNA localization | 43/2311 | 201/18723 | 2.00e-04 | 2.29e-03 | 43 |
GO:00510284 | Cervix | CC | mRNA transport | 31/2311 | 130/18723 | 2.05e-04 | 2.33e-03 | 31 |
GO:00469312 | Cervix | CC | pore complex assembly | 9/2311 | 20/18723 | 3.06e-04 | 3.27e-03 | 9 |
GO:00159318 | Cervix | CC | nucleobase-containing compound transport | 43/2311 | 222/18723 | 1.72e-03 | 1.30e-02 | 43 |
GO:00069991 | Cervix | CC | nuclear pore organization | 6/2311 | 14/18723 | 4.36e-03 | 2.67e-02 | 6 |
GO:00714262 | Cervix | CC | ribonucleoprotein complex export from nucleus | 18/2311 | 76/18723 | 4.45e-03 | 2.71e-02 | 18 |
GO:00711662 | Cervix | CC | ribonucleoprotein complex localization | 18/2311 | 77/18723 | 5.15e-03 | 3.03e-02 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501418 | Cervix | CC | Amyotrophic lateral sclerosis | 103/1267 | 364/8465 | 1.79e-11 | 4.47e-10 | 2.64e-10 | 103 |
hsa0501419 | Cervix | CC | Amyotrophic lateral sclerosis | 103/1267 | 364/8465 | 1.79e-11 | 4.47e-10 | 2.64e-10 | 103 |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa0501428 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa030136 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa05014112 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa0301311 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUP107 | SNV | Missense_Mutation | novel | c.1682N>A | p.Gly561Glu | p.G561E | P57740 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
NUP107 | SNV | Missense_Mutation | rs201038520 | c.1213C>T | p.Arg405Cys | p.R405C | P57740 | protein_coding | tolerated(0.12) | benign(0) | TCGA-VQ-A8PU-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
NUP107 | SNV | Missense_Mutation | novel | c.2747T>G | p.Leu916Arg | p.L916R | P57740 | protein_coding | deleterious(0.01) | possibly_damaging(0.725) | TCGA-VQ-A94P-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
NUP107 | deletion | Frame_Shift_Del | novel | c.2010delN | p.Ile672LeufsTer3 | p.I672Lfs*3 | P57740 | protein_coding | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
57122 | NUP107 | TRANSPORTER | Platinum compounds | 28562428 |
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