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Gene: NUGGC |
Gene summary for NUGGC |
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Gene information | Species | Human | Gene symbol | NUGGC | Gene ID | 389643 |
Gene name | nuclear GTPase, germinal center associated | |
Gene Alias | C8orf80 | |
Cytomap | 8p21.1 | |
Gene Type | protein-coding | GO ID | GO:0002237 | UniProtAcc | Q68CJ6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389643 | NUGGC | HCC1_Meng | Human | Liver | HCC | 4.06e-02 | -9.34e-02 | 0.0246 |
389643 | NUGGC | HCC2_Meng | Human | Liver | HCC | 9.14e-03 | -9.33e-02 | 0.0107 |
389643 | NUGGC | cirrhotic2 | Human | Liver | Cirrhotic | 1.93e-02 | -8.66e-02 | 0.0201 |
389643 | NUGGC | HCC1 | Human | Liver | HCC | 9.24e-13 | 1.75e+00 | 0.5336 |
389643 | NUGGC | HCC2 | Human | Liver | HCC | 1.30e-26 | 3.44e+00 | 0.5341 |
389643 | NUGGC | HCC5 | Human | Liver | HCC | 1.77e-12 | 2.86e+00 | 0.4932 |
389643 | NUGGC | Pt13.a | Human | Liver | HCC | 1.93e-02 | -9.34e-02 | 0.021 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00324966 | Liver | Cirrhotic | response to lipopolysaccharide | 111/4634 | 343/18723 | 8.15e-04 | 5.95e-03 | 111 |
GO:00022376 | Liver | Cirrhotic | response to molecule of bacterial origin | 113/4634 | 363/18723 | 3.23e-03 | 1.81e-02 | 113 |
GO:00062601 | Liver | HCC | DNA replication | 146/7958 | 260/18723 | 5.68e-06 | 7.02e-05 | 146 |
GO:003249611 | Liver | HCC | response to lipopolysaccharide | 174/7958 | 343/18723 | 1.19e-03 | 6.62e-03 | 174 |
GO:00712166 | Liver | HCC | cellular response to biotic stimulus | 128/7958 | 246/18723 | 1.53e-03 | 8.10e-03 | 128 |
GO:00712226 | Liver | HCC | cellular response to lipopolysaccharide | 110/7958 | 209/18723 | 1.92e-03 | 9.77e-03 | 110 |
GO:000223711 | Liver | HCC | response to molecule of bacterial origin | 181/7958 | 363/18723 | 2.58e-03 | 1.24e-02 | 181 |
GO:00062751 | Liver | HCC | regulation of DNA replication | 60/7958 | 107/18723 | 3.15e-03 | 1.46e-02 | 60 |
GO:00712196 | Liver | HCC | cellular response to molecule of bacterial origin | 113/7958 | 221/18723 | 5.73e-03 | 2.38e-02 | 113 |
GO:0006261 | Liver | HCC | DNA-dependent DNA replication | 80/7958 | 151/18723 | 5.91e-03 | 2.44e-02 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUGGC | SNV | Missense_Mutation | novel | c.2101G>A | p.Gly701Ser | p.G701S | Q68CJ6 | protein_coding | deleterious(0.01) | benign(0.05) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
NUGGC | SNV | Missense_Mutation | novel | c.677N>A | p.Pro226His | p.P226H | Q68CJ6 | protein_coding | deleterious(0) | probably_damaging(0.938) | TCGA-BR-6456-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUGGC | SNV | Missense_Mutation | rs568739858 | c.790N>T | p.Arg264Cys | p.R264C | Q68CJ6 | protein_coding | deleterious(0) | possibly_damaging(0.471) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NUGGC | SNV | Missense_Mutation | c.1892N>C | p.Asn631Thr | p.N631T | Q68CJ6 | protein_coding | tolerated(0.32) | benign(0) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
NUGGC | SNV | Missense_Mutation | rs369064910 | c.2164G>A | p.Val722Met | p.V722M | Q68CJ6 | protein_coding | tolerated(0.2) | benign(0.001) | TCGA-FP-7735-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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