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Gene: NSUN2 |
Gene summary for NSUN2 |
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Gene information | Species | Human | Gene symbol | NSUN2 | Gene ID | 54888 |
Gene name | NOP2/Sun RNA methyltransferase 2 | |
Gene Alias | MISU | |
Cytomap | 5p15.31 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q08J23 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54888 | NSUN2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.00e-07 | 5.36e-01 | -0.0811 |
54888 | NSUN2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.32e-05 | 4.29e-01 | -0.1088 |
54888 | NSUN2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.66e-14 | 5.13e-01 | -0.1954 |
54888 | NSUN2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.16e-04 | 3.37e-01 | -0.1464 |
54888 | NSUN2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.90e-05 | 4.11e-01 | -0.059 |
54888 | NSUN2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.10e-03 | 3.70e-01 | 0.0338 |
54888 | NSUN2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 9.21e-03 | 4.32e-01 | 0.0112 |
54888 | NSUN2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.01e-02 | 3.25e-01 | 0.0588 |
54888 | NSUN2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.69e-06 | 3.98e-01 | 0.294 |
54888 | NSUN2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 6.39e-04 | 7.74e-01 | 0.3487 |
54888 | NSUN2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.24e-06 | 4.58e-01 | 0.3859 |
54888 | NSUN2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.46e-04 | 5.84e-01 | 0.2585 |
54888 | NSUN2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.79e-34 | 1.10e+00 | 0.3005 |
54888 | NSUN2 | A015-C-203 | Human | Colorectum | FAP | 8.85e-05 | -8.18e-02 | -0.1294 |
54888 | NSUN2 | A002-C-203 | Human | Colorectum | FAP | 2.10e-02 | -1.32e-01 | 0.2786 |
54888 | NSUN2 | A015-C-104 | Human | Colorectum | FAP | 1.66e-05 | -1.39e-01 | -0.1899 |
54888 | NSUN2 | A002-C-016 | Human | Colorectum | FAP | 2.72e-07 | -2.19e-01 | 0.0521 |
54888 | NSUN2 | A002-C-116 | Human | Colorectum | FAP | 9.90e-09 | -1.53e-01 | -0.0452 |
54888 | NSUN2 | F034 | Human | Colorectum | FAP | 8.94e-05 | -1.39e-01 | -0.0665 |
54888 | NSUN2 | LZE2T | Human | Esophagus | ESCC | 7.31e-04 | 4.89e-01 | 0.082 |
Page: 1 2 3 4 5 6 7 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
GO:0031330 | Colorectum | AD | negative regulation of cellular catabolic process | 104/3918 | 262/18723 | 2.66e-12 | 3.96e-10 | 104 |
GO:0006401 | Colorectum | AD | RNA catabolic process | 102/3918 | 278/18723 | 8.64e-10 | 6.76e-08 | 102 |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0034655 | Colorectum | AD | nucleobase-containing compound catabolic process | 133/3918 | 407/18723 | 1.56e-08 | 9.12e-07 | 133 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0006913 | Colorectum | AD | nucleocytoplasmic transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0051169 | Colorectum | AD | nuclear transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0043487 | Colorectum | AD | regulation of RNA stability | 63/3918 | 170/18723 | 9.17e-07 | 3.12e-05 | 63 |
GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
GO:0051236 | Colorectum | AD | establishment of RNA localization | 58/3918 | 166/18723 | 1.95e-05 | 4.01e-04 | 58 |
GO:0015931 | Colorectum | AD | nucleobase-containing compound transport | 73/3918 | 222/18723 | 2.02e-05 | 4.10e-04 | 73 |
GO:0046822 | Colorectum | AD | regulation of nucleocytoplasmic transport | 41/3918 | 106/18723 | 2.17e-05 | 4.33e-04 | 41 |
GO:0050657 | Colorectum | AD | nucleic acid transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
GO:0050658 | Colorectum | AD | RNA transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:0051168 | Colorectum | AD | nuclear export | 53/3918 | 154/18723 | 6.89e-05 | 1.11e-03 | 53 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NSUN2 | SNV | Missense_Mutation | novel | c.659N>T | p.Arg220Leu | p.R220L | Q08J23 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D6-A6EK-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PR |
NSUN2 | SNV | Missense_Mutation | c.1774N>G | p.Asn592Asp | p.N592D | Q08J23 | protein_coding | tolerated(0.76) | benign(0) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
NSUN2 | SNV | Missense_Mutation | rs200377019 | c.523N>T | p.Arg175Trp | p.R175W | Q08J23 | protein_coding | deleterious(0) | possibly_damaging(0.849) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
NSUN2 | SNV | Missense_Mutation | c.2288T>C | p.Val763Ala | p.V763A | Q08J23 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NSUN2 | SNV | Missense_Mutation | c.677N>G | p.His226Arg | p.H226R | Q08J23 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HU-A4GD-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD | |
NSUN2 | SNV | Missense_Mutation | rs770178867 | c.1972N>A | p.Val658Met | p.V658M | Q08J23 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NSUN2 | SNV | Missense_Mutation | rs371887249 | c.1804C>T | p.Arg602Trp | p.R602W | Q08J23 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-RD-A7C1-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NSUN2 | SNV | Missense_Mutation | novel | c.1721N>G | p.Asn574Ser | p.N574S | Q08J23 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
NSUN2 | SNV | Missense_Mutation | rs745927756 | c.658N>T | p.Arg220Cys | p.R220C | Q08J23 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
NSUN2 | deletion | Frame_Shift_Del | novel | c.798_799delNN | p.Cys267Ter | p.C267* | Q08J23 | protein_coding | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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