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Gene: NNT |
Gene summary for NNT |
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Gene information | Species | Human | Gene symbol | NNT | Gene ID | 23530 |
Gene name | nicotinamide nucleotide transhydrogenase | |
Gene Alias | GCCD4 | |
Cytomap | 5p12 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | E9PCX7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23530 | NNT | LZE4T | Human | Esophagus | ESCC | 5.76e-09 | 2.07e-01 | 0.0811 |
23530 | NNT | LZE7T | Human | Esophagus | ESCC | 4.35e-05 | 3.23e-01 | 0.0667 |
23530 | NNT | LZE8T | Human | Esophagus | ESCC | 1.33e-04 | 2.05e-01 | 0.067 |
23530 | NNT | LZE22T | Human | Esophagus | ESCC | 2.28e-02 | 2.16e-01 | 0.068 |
23530 | NNT | LZE24T | Human | Esophagus | ESCC | 2.98e-10 | 1.80e-01 | 0.0596 |
23530 | NNT | LZE6T | Human | Esophagus | ESCC | 3.07e-04 | 1.59e-01 | 0.0845 |
23530 | NNT | P2T-E | Human | Esophagus | ESCC | 5.99e-17 | 1.72e-01 | 0.1177 |
23530 | NNT | P4T-E | Human | Esophagus | ESCC | 8.17e-11 | 1.94e-01 | 0.1323 |
23530 | NNT | P5T-E | Human | Esophagus | ESCC | 2.36e-05 | 5.12e-02 | 0.1327 |
23530 | NNT | P8T-E | Human | Esophagus | ESCC | 3.45e-30 | 5.33e-01 | 0.0889 |
23530 | NNT | P9T-E | Human | Esophagus | ESCC | 4.94e-05 | 1.10e-01 | 0.1131 |
23530 | NNT | P10T-E | Human | Esophagus | ESCC | 2.32e-30 | 5.56e-01 | 0.116 |
23530 | NNT | P11T-E | Human | Esophagus | ESCC | 8.34e-04 | 2.44e-01 | 0.1426 |
23530 | NNT | P12T-E | Human | Esophagus | ESCC | 6.59e-17 | 2.70e-01 | 0.1122 |
23530 | NNT | P15T-E | Human | Esophagus | ESCC | 2.18e-07 | 1.98e-01 | 0.1149 |
23530 | NNT | P16T-E | Human | Esophagus | ESCC | 7.42e-15 | 2.55e-01 | 0.1153 |
23530 | NNT | P17T-E | Human | Esophagus | ESCC | 6.37e-03 | 2.52e-01 | 0.1278 |
23530 | NNT | P19T-E | Human | Esophagus | ESCC | 6.13e-03 | 2.53e-01 | 0.1662 |
23530 | NNT | P20T-E | Human | Esophagus | ESCC | 1.93e-16 | 2.55e-01 | 0.1124 |
23530 | NNT | P21T-E | Human | Esophagus | ESCC | 1.69e-14 | 2.92e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00426923 | Breast | IDC | muscle cell differentiation | 44/1434 | 384/18723 | 4.77e-03 | 3.66e-02 | 44 |
GO:00030125 | Breast | IDC | muscle system process | 50/1434 | 452/18723 | 5.52e-03 | 4.05e-02 | 50 |
GO:00511463 | Breast | IDC | striated muscle cell differentiation | 34/1434 | 283/18723 | 6.00e-03 | 4.31e-02 | 34 |
GO:000301212 | Breast | DCIS | muscle system process | 50/1390 | 452/18723 | 3.02e-03 | 2.57e-02 | 50 |
GO:004269211 | Breast | DCIS | muscle cell differentiation | 43/1390 | 384/18723 | 4.56e-03 | 3.49e-02 | 43 |
GO:00310328 | Breast | DCIS | actomyosin structure organization | 25/1390 | 196/18723 | 5.59e-03 | 4.06e-02 | 25 |
GO:005114611 | Breast | DCIS | striated muscle cell differentiation | 33/1390 | 283/18723 | 6.63e-03 | 4.62e-02 | 33 |
GO:00310329 | Cervix | CC | actomyosin structure organization | 43/2311 | 196/18723 | 1.11e-04 | 1.40e-03 | 43 |
GO:00426924 | Cervix | CC | muscle cell differentiation | 69/2311 | 384/18723 | 8.12e-04 | 7.09e-03 | 69 |
GO:00511464 | Cervix | CC | striated muscle cell differentiation | 50/2311 | 283/18723 | 5.53e-03 | 3.19e-02 | 50 |
GO:00902578 | Cervix | CC | regulation of muscle system process | 45/2311 | 252/18723 | 6.73e-03 | 3.70e-02 | 45 |
GO:00435024 | Cervix | CC | regulation of muscle adaptation | 21/2311 | 98/18723 | 7.71e-03 | 4.09e-02 | 21 |
GO:005114612 | Cervix | HSIL_HPV | striated muscle cell differentiation | 22/737 | 283/18723 | 1.94e-03 | 2.04e-02 | 22 |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:0045333110 | Esophagus | ESCC | cellular respiration | 173/8552 | 230/18723 | 4.53e-20 | 5.99e-18 | 173 |
GO:0009060110 | Esophagus | ESCC | aerobic respiration | 145/8552 | 189/18723 | 2.16e-18 | 2.21e-16 | 145 |
GO:0015980110 | Esophagus | ESCC | energy derivation by oxidation of organic compounds | 220/8552 | 318/18723 | 1.20e-17 | 1.09e-15 | 220 |
GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
NNT | MYOFIB | Stomach | CAG with IM | CENPK,NMNAT3,ACTG2, etc. | 1.90e-01 | ![]() |
NNT | MYOFIB | Stomach | SIM | CENPK,NMNAT3,ACTG2, etc. | 1.50e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NNT | SNV | Missense_Mutation | novel | c.1651N>C | p.Tyr551His | p.Y551H | Q13423 | protein_coding | tolerated(0.06) | benign(0.017) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NNT | insertion | Frame_Shift_Ins | novel | c.863_864insT | p.Ala289CysfsTer10 | p.A289Cfs*10 | Q13423 | protein_coding | TCGA-HD-8635-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
NNT | SNV | Missense_Mutation | c.727N>A | p.Ala243Thr | p.A243T | Q13423 | protein_coding | deleterious(0) | benign(0.428) | TCGA-FC-A4JI-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Hormone Therapy | casodex | CR | |
NNT | SNV | Missense_Mutation | rs761727766 | c.697N>A | p.Val233Ile | p.V233I | Q13423 | protein_coding | tolerated(1) | benign(0.003) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NNT | SNV | Missense_Mutation | c.2051N>A | p.Gly684Asp | p.G684D | Q13423 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-BR-6565-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NNT | SNV | Missense_Mutation | rs759786744 | c.1933N>T | p.Arg645Cys | p.R645C | Q13423 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR |
NNT | SNV | Missense_Mutation | c.106N>G | p.Phe36Val | p.F36V | Q13423 | protein_coding | tolerated(0.09) | benign(0.013) | TCGA-BR-8679-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NNT | SNV | Missense_Mutation | c.2497G>A | p.Val833Ile | p.V833I | Q13423 | protein_coding | deleterious(0.03) | possibly_damaging(0.737) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NNT | SNV | Missense_Mutation | c.2897N>A | p.Ala966Glu | p.A966E | Q13423 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-4444-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
NNT | SNV | Missense_Mutation | c.672A>C | p.Lys224Asn | p.K224N | Q13423 | protein_coding | deleterious(0.04) | probably_damaging(0.965) | TCGA-D7-6528-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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