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Gene: NDST3 |
Gene summary for NDST3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NDST3 | Gene ID | 9348 |
Gene name | N-deacetylase and N-sulfotransferase 3 | |
Gene Alias | HSST3 | |
Cytomap | 4q26 | |
Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | O95803 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9348 | NDST3 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.76e-04 | 3.30e-01 | -0.1088 |
9348 | NDST3 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.81e-10 | 3.80e-01 | -0.1954 |
9348 | NDST3 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.84e-09 | 3.69e-01 | -0.1464 |
9348 | NDST3 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.80e-03 | 1.66e-01 | -0.1001 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDST3 | SNV | Missense_Mutation | novel | c.1881N>G | p.Ser627Arg | p.S627R | O95803 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-RC-A6M3-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NDST3 | SNV | Missense_Mutation | rs150758016 | c.1279G>A | p.Val427Ile | p.V427I | O95803 | protein_coding | deleterious(0.04) | possibly_damaging(0.908) | TCGA-05-4425-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
NDST3 | SNV | Missense_Mutation | novel | c.1418C>G | p.Pro473Arg | p.P473R | O95803 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
NDST3 | SNV | Missense_Mutation | novel | c.451G>A | p.Asp151Asn | p.D151N | O95803 | protein_coding | deleterious(0) | possibly_damaging(0.673) | TCGA-49-6742-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | alimta | PD |
NDST3 | SNV | Missense_Mutation | c.2277N>G | p.Phe759Leu | p.F759L | O95803 | protein_coding | deleterious(0.05) | benign(0.222) | TCGA-50-5051-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
NDST3 | SNV | Missense_Mutation | novel | c.1787C>A | p.Pro596Gln | p.P596Q | O95803 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD |
NDST3 | SNV | Missense_Mutation | c.2315N>A | p.Leu772Gln | p.L772Q | O95803 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-55-8090-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NDST3 | SNV | Missense_Mutation | novel | c.1554N>C | p.Met518Ile | p.M518I | O95803 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-55-8614-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NDST3 | SNV | Missense_Mutation | c.1523N>A | p.Thr508Asn | p.T508N | O95803 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-64-1676-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NDST3 | SNV | Missense_Mutation | novel | c.1404C>A | p.Asn468Lys | p.N468K | O95803 | protein_coding | deleterious(0.01) | benign(0.232) | TCGA-MN-A4N1-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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