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Gene: N4BP1 |
Gene summary for N4BP1 |
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Gene information | Species | Human | Gene symbol | N4BP1 | Gene ID | 9683 |
Gene name | NEDD4 binding protein 1 | |
Gene Alias | N4BP1 | |
Cytomap | 16q12.1 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | O75113 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9683 | N4BP1 | CCI_1 | Human | Cervix | CC | 1.52e-03 | 6.20e-01 | 0.528 |
9683 | N4BP1 | CCI_2 | Human | Cervix | CC | 2.70e-07 | 1.04e+00 | 0.5249 |
9683 | N4BP1 | CCI_3 | Human | Cervix | CC | 5.41e-06 | 8.63e-01 | 0.516 |
9683 | N4BP1 | sample3 | Human | Cervix | CC | 1.14e-04 | 2.31e-01 | 0.1387 |
9683 | N4BP1 | T3 | Human | Cervix | CC | 1.94e-04 | 2.46e-01 | 0.1389 |
9683 | N4BP1 | LZE4T | Human | Esophagus | ESCC | 2.67e-11 | 3.32e-01 | 0.0811 |
9683 | N4BP1 | LZE7T | Human | Esophagus | ESCC | 5.24e-07 | 2.85e-01 | 0.0667 |
9683 | N4BP1 | LZE8T | Human | Esophagus | ESCC | 9.08e-07 | 1.35e-01 | 0.067 |
9683 | N4BP1 | LZE20T | Human | Esophagus | ESCC | 3.68e-07 | 3.43e-01 | 0.0662 |
9683 | N4BP1 | LZE22T | Human | Esophagus | ESCC | 8.82e-04 | 2.97e-01 | 0.068 |
9683 | N4BP1 | LZE24T | Human | Esophagus | ESCC | 2.50e-17 | 4.24e-01 | 0.0596 |
9683 | N4BP1 | LZE21T | Human | Esophagus | ESCC | 3.02e-05 | 2.78e-01 | 0.0655 |
9683 | N4BP1 | P1T-E | Human | Esophagus | ESCC | 8.86e-17 | 7.60e-01 | 0.0875 |
9683 | N4BP1 | P2T-E | Human | Esophagus | ESCC | 7.05e-32 | 1.67e-01 | 0.1177 |
9683 | N4BP1 | P4T-E | Human | Esophagus | ESCC | 9.70e-20 | 5.09e-01 | 0.1323 |
9683 | N4BP1 | P5T-E | Human | Esophagus | ESCC | 4.29e-22 | 3.85e-01 | 0.1327 |
9683 | N4BP1 | P8T-E | Human | Esophagus | ESCC | 9.09e-16 | 2.80e-01 | 0.0889 |
9683 | N4BP1 | P9T-E | Human | Esophagus | ESCC | 1.06e-09 | 1.74e-01 | 0.1131 |
9683 | N4BP1 | P10T-E | Human | Esophagus | ESCC | 2.67e-15 | 1.23e-01 | 0.116 |
9683 | N4BP1 | P11T-E | Human | Esophagus | ESCC | 2.06e-10 | 4.49e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603210 | Cervix | CC | viral process | 109/2311 | 415/18723 | 5.40e-15 | 6.46e-12 | 109 |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:001905810 | Cervix | CC | viral life cycle | 87/2311 | 317/18723 | 2.20e-13 | 1.20e-10 | 87 |
GO:190336210 | Cervix | CC | regulation of cellular protein catabolic process | 72/2311 | 255/18723 | 5.98e-12 | 2.10e-09 | 72 |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:190332010 | Cervix | CC | regulation of protein modification by small protein conjugation or removal | 66/2311 | 242/18723 | 2.31e-10 | 3.46e-08 | 66 |
GO:003139610 | Cervix | CC | regulation of protein ubiquitination | 59/2311 | 210/18723 | 5.90e-10 | 7.51e-08 | 59 |
GO:190305010 | Cervix | CC | regulation of proteolysis involved in cellular protein catabolic process | 60/2311 | 221/18723 | 1.82e-09 | 1.98e-07 | 60 |
GO:200005810 | Cervix | CC | regulation of ubiquitin-dependent protein catabolic process | 47/2311 | 164/18723 | 1.63e-08 | 1.25e-06 | 47 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:004586110 | Cervix | CC | negative regulation of proteolysis | 80/2311 | 351/18723 | 2.88e-08 | 1.98e-06 | 80 |
GO:003133010 | Cervix | CC | negative regulation of cellular catabolic process | 63/2311 | 262/18723 | 1.10e-07 | 5.68e-06 | 63 |
GO:003139710 | Cervix | CC | negative regulation of protein ubiquitination | 28/2311 | 83/18723 | 3.32e-07 | 1.35e-05 | 28 |
GO:006113610 | Cervix | CC | regulation of proteasomal protein catabolic process | 48/2311 | 187/18723 | 4.63e-07 | 1.77e-05 | 48 |
GO:003243410 | Cervix | CC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 38/2311 | 134/18723 | 4.99e-07 | 1.88e-05 | 38 |
GO:190332110 | Cervix | CC | negative regulation of protein modification by small protein conjugation or removal | 29/2311 | 95/18723 | 2.15e-06 | 6.55e-05 | 29 |
GO:000989510 | Cervix | CC | negative regulation of catabolic process | 69/2311 | 320/18723 | 2.15e-06 | 6.55e-05 | 69 |
GO:001907910 | Cervix | CC | viral genome replication | 35/2311 | 131/18723 | 6.11e-06 | 1.49e-04 | 35 |
GO:19033639 | Cervix | CC | negative regulation of cellular protein catabolic process | 24/2311 | 75/18723 | 6.43e-06 | 1.55e-04 | 24 |
GO:00712148 | Cervix | CC | cellular response to abiotic stimulus | 69/2311 | 331/18723 | 7.36e-06 | 1.73e-04 | 69 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
N4BP1 | SNV | Missense_Mutation | novel | c.545N>G | p.Leu182Trp | p.L182W | O75113 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-96-A4JL-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | gemzar | CR |
N4BP1 | SNV | Missense_Mutation | novel | c.1121C>A | p.Ser374Tyr | p.S374Y | O75113 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-98-A538-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
N4BP1 | insertion | Frame_Shift_Ins | novel | c.378_379insT | p.Val127CysfsTer5 | p.V127Cfs*5 | O75113 | protein_coding | TCGA-55-8207-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
N4BP1 | SNV | Missense_Mutation | c.839G>C | p.Arg280Thr | p.R280T | O75113 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-BA-A6DA-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
N4BP1 | SNV | Missense_Mutation | novel | c.553N>C | p.Glu185Gln | p.E185Q | O75113 | protein_coding | deleterious(0) | possibly_damaging(0.722) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
N4BP1 | SNV | Missense_Mutation | novel | c.1417N>A | p.Glu473Lys | p.E473K | O75113 | protein_coding | tolerated(0.42) | benign(0.086) | TCGA-CR-6472-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
N4BP1 | SNV | Missense_Mutation | novel | c.2276N>A | p.Pro759His | p.P759H | O75113 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CR-7367-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
N4BP1 | SNV | Missense_Mutation | novel | c.1177G>C | p.Glu393Gln | p.E393Q | O75113 | protein_coding | deleterious(0.04) | benign(0.307) | TCGA-WA-A7H4-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
N4BP1 | SNV | Missense_Mutation | c.2462N>A | p.Ser821Asn | p.S821N | O75113 | protein_coding | deleterious(0.02) | benign(0) | TCGA-BR-4363-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
N4BP1 | SNV | Missense_Mutation | c.2053G>A | p.Gly685Arg | p.G685R | O75113 | protein_coding | tolerated(0.29) | possibly_damaging(0.705) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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