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Gene: MPHOSPH10 |
Gene summary for MPHOSPH10 |
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Gene information | Species | Human | Gene symbol | MPHOSPH10 | Gene ID | 10199 |
Gene name | M-phase phosphoprotein 10 | |
Gene Alias | CT90 | |
Cytomap | 2p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | O00566 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10199 | MPHOSPH10 | LZE2T | Human | Esophagus | ESCC | 1.49e-02 | 8.29e-01 | 0.082 |
10199 | MPHOSPH10 | LZE4T | Human | Esophagus | ESCC | 6.52e-22 | 6.48e-01 | 0.0811 |
10199 | MPHOSPH10 | LZE5T | Human | Esophagus | ESCC | 1.63e-02 | 1.72e-01 | 0.0514 |
10199 | MPHOSPH10 | LZE7T | Human | Esophagus | ESCC | 9.71e-09 | 4.27e-01 | 0.0667 |
10199 | MPHOSPH10 | LZE8T | Human | Esophagus | ESCC | 2.02e-06 | 1.39e-01 | 0.067 |
10199 | MPHOSPH10 | LZE20T | Human | Esophagus | ESCC | 1.36e-02 | 7.16e-02 | 0.0662 |
10199 | MPHOSPH10 | LZE22T | Human | Esophagus | ESCC | 4.44e-04 | 3.78e-01 | 0.068 |
10199 | MPHOSPH10 | LZE24T | Human | Esophagus | ESCC | 2.98e-11 | 2.55e-01 | 0.0596 |
10199 | MPHOSPH10 | LZE6T | Human | Esophagus | ESCC | 1.82e-02 | 1.30e-01 | 0.0845 |
10199 | MPHOSPH10 | P1T-E | Human | Esophagus | ESCC | 1.87e-15 | 8.53e-01 | 0.0875 |
10199 | MPHOSPH10 | P2T-E | Human | Esophagus | ESCC | 1.45e-41 | 7.32e-01 | 0.1177 |
10199 | MPHOSPH10 | P4T-E | Human | Esophagus | ESCC | 6.93e-41 | 9.51e-01 | 0.1323 |
10199 | MPHOSPH10 | P5T-E | Human | Esophagus | ESCC | 1.71e-38 | 7.05e-01 | 0.1327 |
10199 | MPHOSPH10 | P8T-E | Human | Esophagus | ESCC | 2.32e-28 | 3.37e-01 | 0.0889 |
10199 | MPHOSPH10 | P9T-E | Human | Esophagus | ESCC | 4.12e-19 | 4.51e-01 | 0.1131 |
10199 | MPHOSPH10 | P10T-E | Human | Esophagus | ESCC | 1.18e-49 | 8.12e-01 | 0.116 |
10199 | MPHOSPH10 | P11T-E | Human | Esophagus | ESCC | 1.21e-20 | 6.51e-01 | 0.1426 |
10199 | MPHOSPH10 | P12T-E | Human | Esophagus | ESCC | 8.60e-39 | 6.26e-01 | 0.1122 |
10199 | MPHOSPH10 | P15T-E | Human | Esophagus | ESCC | 7.25e-31 | 7.08e-01 | 0.1149 |
10199 | MPHOSPH10 | P16T-E | Human | Esophagus | ESCC | 2.88e-41 | 8.36e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:000037512 | Liver | Cirrhotic | RNA splicing, via transesterification reactions | 175/4634 | 324/18723 | 5.95e-30 | 7.47e-27 | 175 |
GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
GO:000636412 | Liver | Cirrhotic | rRNA processing | 115/4634 | 225/18723 | 1.12e-17 | 1.64e-15 | 115 |
GO:00160724 | Liver | Cirrhotic | rRNA metabolic process | 119/4634 | 236/18723 | 1.19e-17 | 1.70e-15 | 119 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MPHOSPH10 | SNV | Missense_Mutation | novel | c.160N>A | p.Glu54Lys | p.E54K | O00566 | protein_coding | tolerated(0.2) | benign(0.045) | TCGA-CD-8533-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | capecitabine | PD |
MPHOSPH10 | SNV | Missense_Mutation | novel | c.1916N>T | p.Ala639Val | p.A639V | O00566 | protein_coding | tolerated(0.12) | possibly_damaging(0.773) | TCGA-VQ-A91K-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
MPHOSPH10 | deletion | Frame_Shift_Del | c.711delT | p.Phe237LeufsTer28 | p.F237Lfs*28 | O00566 | protein_coding | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
MPHOSPH10 | insertion | Frame_Shift_Ins | novel | c.711dupT | p.Glu238Ter | p.E238* | O00566 | protein_coding | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
MPHOSPH10 | SNV | Missense_Mutation | novel | c.2012N>T | p.Arg671Ile | p.R671I | O00566 | protein_coding | deleterious(0.01) | benign(0.025) | TCGA-EL-A3ZM-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MPHOSPH10 | insertion | In_Frame_Ins | novel | c.2013_2014insGTACAT | p.Arg671_Gln672insValHis | p.R671_Q672insVH | O00566 | protein_coding | TCGA-BJ-A45E-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MPHOSPH10 | insertion | In_Frame_Ins | novel | c.2013_2014insGTACAT | p.Arg671_Gln672insValHis | p.R671_Q672insVH | O00566 | protein_coding | TCGA-EL-A3ZM-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
MPHOSPH10 | insertion | In_Frame_Ins | novel | c.154_155insATAAAAAAAACCCAACTC | p.Ile52delinsAsnLysLysAsnProThrLeu | p.I52delinsNKKNPTL | O00566 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
MPHOSPH10 | insertion | Nonsense_Mutation | novel | c.622_623insAAATCTTCTAGGTC | p.Ser208Ter | p.S208* | O00566 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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