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Gene: MICAL2 |
Gene summary for MICAL2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | MICAL2 | Gene ID | 9645 |
Gene name | microtubule associated monooxygenase, calponin and LIM domain containing 2 | |
Gene Alias | Ebitein1 | |
Cytomap | 11p15.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O94851 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9645 | MICAL2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.61e-03 | -3.62e-01 | 0.0155 |
9645 | MICAL2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.10e-10 | 7.45e-01 | -0.1808 |
9645 | MICAL2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.77e-07 | 6.29e-01 | -0.0811 |
9645 | MICAL2 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.77e-03 | 5.44e-01 | -0.1088 |
9645 | MICAL2 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.34e-25 | 9.37e-01 | -0.1954 |
9645 | MICAL2 | HTA11_411_2000001011 | Human | Colorectum | SER | 8.29e-07 | 1.45e+00 | -0.2602 |
9645 | MICAL2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.27e-05 | 9.66e-01 | -0.2196 |
9645 | MICAL2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.62e-05 | 7.27e-01 | -0.1526 |
9645 | MICAL2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.41e-09 | 8.76e-01 | -0.1464 |
9645 | MICAL2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.70e-03 | 5.51e-01 | -0.059 |
9645 | MICAL2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.15e-06 | 8.99e-01 | -0.2061 |
9645 | MICAL2 | A002-C-010 | Human | Colorectum | FAP | 1.98e-02 | -1.66e-01 | 0.242 |
9645 | MICAL2 | A015-C-203 | Human | Colorectum | FAP | 1.11e-20 | -3.81e-01 | -0.1294 |
9645 | MICAL2 | A015-C-204 | Human | Colorectum | FAP | 9.47e-04 | -2.47e-01 | -0.0228 |
9645 | MICAL2 | A014-C-040 | Human | Colorectum | FAP | 2.95e-03 | -4.40e-01 | -0.1184 |
9645 | MICAL2 | A002-C-201 | Human | Colorectum | FAP | 1.16e-10 | -2.79e-01 | 0.0324 |
9645 | MICAL2 | A001-C-119 | Human | Colorectum | FAP | 8.91e-07 | -3.45e-01 | -0.1557 |
9645 | MICAL2 | A001-C-108 | Human | Colorectum | FAP | 5.26e-11 | -1.83e-01 | -0.0272 |
9645 | MICAL2 | A002-C-205 | Human | Colorectum | FAP | 6.86e-18 | -3.92e-01 | -0.1236 |
9645 | MICAL2 | A015-C-005 | Human | Colorectum | FAP | 9.80e-04 | -2.45e-01 | -0.0336 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
GO:0030042 | Colorectum | AD | actin filament depolymerization | 27/3918 | 59/18723 | 1.65e-05 | 3.47e-04 | 27 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:0060562 | Colorectum | AD | epithelial tube morphogenesis | 93/3918 | 325/18723 | 5.65e-04 | 6.00e-03 | 93 |
GO:0043624 | Colorectum | AD | cellular protein complex disassembly | 45/3918 | 136/18723 | 6.24e-04 | 6.48e-03 | 45 |
GO:0051261 | Colorectum | AD | protein depolymerization | 39/3918 | 114/18723 | 6.74e-04 | 6.91e-03 | 39 |
GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
GO:00070151 | Colorectum | SER | actin filament organization | 134/2897 | 442/18723 | 1.39e-15 | 5.70e-13 | 134 |
GO:00081541 | Colorectum | SER | actin polymerization or depolymerization | 77/2897 | 218/18723 | 3.50e-13 | 1.19e-10 | 77 |
GO:00224111 | Colorectum | SER | cellular component disassembly | 114/2897 | 443/18723 | 1.17e-08 | 9.59e-07 | 114 |
GO:00329841 | Colorectum | SER | protein-containing complex disassembly | 61/2897 | 224/18723 | 4.17e-06 | 1.60e-04 | 61 |
GO:00300421 | Colorectum | SER | actin filament depolymerization | 23/2897 | 59/18723 | 1.02e-05 | 3.34e-04 | 23 |
GO:00436241 | Colorectum | SER | cellular protein complex disassembly | 37/2897 | 136/18723 | 3.08e-04 | 5.00e-03 | 37 |
GO:00512611 | Colorectum | SER | protein depolymerization | 31/2897 | 114/18723 | 9.18e-04 | 1.11e-02 | 31 |
GO:00067901 | Colorectum | SER | sulfur compound metabolic process | 73/2897 | 339/18723 | 1.75e-03 | 1.81e-02 | 73 |
GO:00070154 | Colorectum | FAP | actin filament organization | 125/2622 | 442/18723 | 1.97e-15 | 3.03e-12 | 125 |
GO:00081544 | Colorectum | FAP | actin polymerization or depolymerization | 60/2622 | 218/18723 | 1.15e-07 | 7.43e-06 | 60 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MICAL2 | SNV | Missense_Mutation | c.3208N>A | p.Ala1070Thr | p.A1070T | O94851 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-CH-5753-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD | |
MICAL2 | SNV | Missense_Mutation | rs776677527 | c.2062N>A | p.Glu688Lys | p.E688K | O94851 | protein_coding | deleterious(0) | benign(0.251) | TCGA-V1-A9ZG-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
MICAL2 | SNV | Missense_Mutation | rs764483530 | c.376G>A | p.Val126Met | p.V126M | O94851 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MICAL2 | SNV | Missense_Mutation | novel | c.1400N>A | p.Pro467Gln | p.P467Q | O94851 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-6565-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MICAL2 | SNV | Missense_Mutation | c.819N>T | p.Lys273Asn | p.K273N | O94851 | protein_coding | deleterious(0) | benign(0.277) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MICAL2 | SNV | Missense_Mutation | c.3323N>A | p.Gly1108Asp | p.G1108D | O94851 | protein_coding | tolerated_low_confidence(0.3) | benign(0.001) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MICAL2 | SNV | Missense_Mutation | novel | c.686N>C | p.Leu229Pro | p.L229P | O94851 | protein_coding | deleterious(0) | benign(0.09) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
MICAL2 | SNV | Missense_Mutation | c.1045N>A | p.Tyr349Asn | p.Y349N | O94851 | protein_coding | deleterious(0.01) | possibly_damaging(0.791) | TCGA-CD-5800-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MICAL2 | SNV | Missense_Mutation | rs766049584 | c.674G>A | p.Arg225His | p.R225H | O94851 | protein_coding | deleterious(0.01) | benign(0.014) | TCGA-CD-8531-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | epirubicin | CR |
MICAL2 | SNV | Missense_Mutation | c.1420C>G | p.Leu474Val | p.L474V | O94851 | protein_coding | tolerated(0.15) | benign(0.024) | TCGA-CD-8531-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | epirubicin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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