![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MAST3 |
Gene summary for MAST3 |
![]() |
Gene information | Species | Human | Gene symbol | MAST3 | Gene ID | 23031 |
Gene name | microtubule associated serine/threonine kinase 3 | |
Gene Alias | MAST3 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | O60307 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23031 | MAST3 | HCC1_Meng | Human | Liver | HCC | 3.46e-12 | -3.69e-03 | 0.0246 |
23031 | MAST3 | HCC1 | Human | Liver | HCC | 2.93e-04 | 3.09e+00 | 0.5336 |
23031 | MAST3 | HCC2 | Human | Liver | HCC | 1.39e-07 | 2.72e+00 | 0.5341 |
23031 | MAST3 | S014 | Human | Liver | HCC | 5.35e-12 | 4.94e-01 | 0.2254 |
23031 | MAST3 | S015 | Human | Liver | HCC | 9.45e-09 | 4.89e-01 | 0.2375 |
23031 | MAST3 | S016 | Human | Liver | HCC | 2.18e-13 | 4.85e-01 | 0.2243 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001810511 | Liver | HCC | peptidyl-serine phosphorylation | 169/7958 | 315/18723 | 3.86e-05 | 3.81e-04 | 169 |
GO:001820911 | Liver | HCC | peptidyl-serine modification | 177/7958 | 338/18723 | 1.45e-04 | 1.17e-03 | 177 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAST3 | SNV | Missense_Mutation | novel | c.3848G>C | p.Gly1283Ala | p.G1283A | O60307 | protein_coding | tolerated_low_confidence(0.12) | benign(0) | TCGA-L9-A5IP-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
MAST3 | SNV | Missense_Mutation | novel | c.2102N>T | p.Ser701Phe | p.S701F | O60307 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
MAST3 | SNV | Missense_Mutation | novel | c.79N>C | p.Ser27Arg | p.S27R | O60307 | protein_coding | deleterious(0) | possibly_damaging(0.852) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MAST3 | SNV | Missense_Mutation | novel | c.895G>C | p.Ala299Pro | p.A299P | O60307 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-60-2724-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD |
MAST3 | SNV | Missense_Mutation | novel | c.679N>T | p.Ala227Ser | p.A227S | O60307 | protein_coding | tolerated(0.19) | benign(0.062) | TCGA-63-A5MP-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
MAST3 | SNV | Missense_Mutation | novel | c.1712N>G | p.Tyr571Cys | p.Y571C | O60307 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-85-7697-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
MAST3 | SNV | Missense_Mutation | c.1732N>T | p.Val578Leu | p.V578L | O60307 | protein_coding | deleterious(0) | possibly_damaging(0.548) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MAST3 | SNV | Missense_Mutation | novel | c.776N>T | p.Ser259Ile | p.S259I | O60307 | protein_coding | deleterious(0.02) | probably_damaging(0.922) | TCGA-NC-A5HH-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MAST3 | deletion | Frame_Shift_Del | novel | c.1642delN | p.Ala548ProfsTer4 | p.A548Pfs*4 | O60307 | protein_coding | TCGA-85-A4QR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
MAST3 | SNV | Missense_Mutation | novel | c.2021G>T | p.Arg674Leu | p.R674L | O60307 | protein_coding | deleterious(0) | probably_damaging(0.949) | TCGA-CN-6988-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23031 | MAST3 | KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE, ENZYME | inhibitor | 252827499 |
Page: 1 |