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Gene: MACF1 |
Gene summary for MACF1 |
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Gene information | Species | Human | Gene symbol | MACF1 | Gene ID | 23499 |
Gene name | microtubule actin crosslinking factor 1 | |
Gene Alias | ABP620 | |
Cytomap | 1p34.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q6ZSD7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23499 | MACF1 | CA_HPV_1 | Human | Cervix | CC | 1.75e-09 | -6.32e-03 | 0.0264 |
23499 | MACF1 | CA_HPV_2 | Human | Cervix | CC | 3.26e-04 | 2.58e-01 | 0.0391 |
23499 | MACF1 | CA_HPV_3 | Human | Cervix | CC | 3.75e-06 | 1.95e-01 | 0.0414 |
23499 | MACF1 | CCI_1 | Human | Cervix | CC | 3.10e-07 | 1.90e+00 | 0.528 |
23499 | MACF1 | CCI_3 | Human | Cervix | CC | 4.30e-07 | 8.53e-01 | 0.516 |
23499 | MACF1 | L1 | Human | Cervix | CC | 2.02e-03 | -2.11e-01 | 0.0802 |
23499 | MACF1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.53e-07 | -5.00e-01 | 0.0155 |
23499 | MACF1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.58e-02 | 3.33e-01 | -0.1954 |
23499 | MACF1 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.52e-04 | 7.96e-01 | -0.2602 |
23499 | MACF1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.60e-06 | -4.24e-01 | -0.1207 |
23499 | MACF1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.32e-02 | -2.85e-01 | 0.3005 |
23499 | MACF1 | A001-C-207 | Human | Colorectum | FAP | 1.19e-03 | 7.55e-02 | 0.1278 |
23499 | MACF1 | A015-C-203 | Human | Colorectum | FAP | 3.23e-32 | -1.08e-01 | -0.1294 |
23499 | MACF1 | A015-C-204 | Human | Colorectum | FAP | 5.53e-03 | -3.77e-02 | -0.0228 |
23499 | MACF1 | A014-C-040 | Human | Colorectum | FAP | 8.51e-03 | -2.24e-01 | -0.1184 |
23499 | MACF1 | A002-C-201 | Human | Colorectum | FAP | 7.61e-10 | -5.76e-02 | 0.0324 |
23499 | MACF1 | A002-C-203 | Human | Colorectum | FAP | 7.70e-04 | -2.80e-02 | 0.2786 |
23499 | MACF1 | A001-C-119 | Human | Colorectum | FAP | 9.67e-17 | 3.38e-01 | -0.1557 |
23499 | MACF1 | A001-C-108 | Human | Colorectum | FAP | 2.71e-18 | 2.76e-01 | -0.0272 |
23499 | MACF1 | A002-C-205 | Human | Colorectum | FAP | 6.91e-27 | 6.46e-02 | -0.1236 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
GO:001081010 | Cervix | CC | regulation of cell-substrate adhesion | 69/2311 | 221/18723 | 8.57e-14 | 5.69e-11 | 69 |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:01501159 | Cervix | CC | cell-substrate junction organization | 37/2311 | 101/18723 | 3.20e-10 | 4.46e-08 | 37 |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:00070448 | Cervix | CC | cell-substrate junction assembly | 34/2311 | 95/18723 | 3.35e-09 | 3.45e-07 | 34 |
GO:001063210 | Cervix | CC | regulation of epithelial cell migration | 72/2311 | 292/18723 | 4.52e-09 | 4.43e-07 | 72 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00019528 | Cervix | CC | regulation of cell-matrix adhesion | 40/2311 | 128/18723 | 1.32e-08 | 1.04e-06 | 40 |
GO:00071608 | Cervix | CC | cell-matrix adhesion | 60/2311 | 233/18723 | 1.58e-08 | 1.23e-06 | 60 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
GO:01501169 | Cervix | CC | regulation of cell-substrate junction organization | 25/2311 | 71/18723 | 5.58e-07 | 2.06e-05 | 25 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MACF1 | SNV | Missense_Mutation | rs183077332 | c.14921N>A | p.Arg4974His | p.R4974H | Q9UPN3 | protein_coding | deleterious(0.02) | probably_damaging(0.977) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MACF1 | SNV | Missense_Mutation | rs191298596 | c.929C>T | p.Thr310Met | p.T310M | Q9UPN3 | protein_coding | deleterious(0.02) | possibly_damaging(0.579) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MACF1 | SNV | Missense_Mutation | rs186743740 | c.34N>T | p.Arg12Trp | p.R12W | Q9UPN3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MACF1 | SNV | Missense_Mutation | c.14020G>C | p.Asp4674His | p.D4674H | Q9UPN3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6531-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MACF1 | SNV | Missense_Mutation | c.9672N>T | p.Leu3224Phe | p.L3224F | Q9UPN3 | protein_coding | tolerated(0.07) | probably_damaging(0.995) | TCGA-D5-6926-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
MACF1 | SNV | Missense_Mutation | rs747182535 | c.15235N>T | p.Arg5079Cys | p.R5079C | Q9UPN3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MACF1 | SNV | Missense_Mutation | novel | c.12958N>A | p.Ala4320Thr | p.A4320T | Q9UPN3 | protein_coding | tolerated(0.06) | probably_damaging(0.925) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MACF1 | SNV | Missense_Mutation | c.14056N>G | p.Thr4686Ala | p.T4686A | Q9UPN3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MACF1 | SNV | Missense_Mutation | rs369062828 | c.3014N>A | p.Arg1005His | p.R1005H | Q9UPN3 | protein_coding | tolerated(0.12) | benign(0.001) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MACF1 | SNV | Missense_Mutation | c.11725N>G | p.Asn3909Asp | p.N3909D | Q9UPN3 | protein_coding | tolerated(0.3) | benign(0.253) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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