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Gene: KLHL13 |
Gene summary for KLHL13 |
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Gene information | Species | Human | Gene symbol | KLHL13 | Gene ID | 90293 |
Gene name | kelch like family member 13 | |
Gene Alias | BKLHD2 | |
Cytomap | Xq24 | |
Gene Type | protein-coding | GO ID | GO:0000910 | UniProtAcc | A0A0C4DG99 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90293 | KLHL13 | CCI_1 | Human | Cervix | CC | 1.87e-03 | 5.03e-01 | 0.528 |
90293 | KLHL13 | CCI_2 | Human | Cervix | CC | 1.65e-05 | 6.79e-01 | 0.5249 |
90293 | KLHL13 | LZE2T | Human | Esophagus | ESCC | 7.42e-03 | 4.88e-01 | 0.082 |
90293 | KLHL13 | LZE4T | Human | Esophagus | ESCC | 4.25e-09 | 2.63e-01 | 0.0811 |
90293 | KLHL13 | LZE7T | Human | Esophagus | ESCC | 1.43e-03 | 2.75e-01 | 0.0667 |
90293 | KLHL13 | LZE24T | Human | Esophagus | ESCC | 1.80e-16 | 4.18e-01 | 0.0596 |
90293 | KLHL13 | P1T-E | Human | Esophagus | ESCC | 4.54e-02 | 1.19e-01 | 0.0875 |
90293 | KLHL13 | P2T-E | Human | Esophagus | ESCC | 1.40e-29 | 5.70e-01 | 0.1177 |
90293 | KLHL13 | P4T-E | Human | Esophagus | ESCC | 5.70e-09 | 1.64e-01 | 0.1323 |
90293 | KLHL13 | P8T-E | Human | Esophagus | ESCC | 1.24e-08 | 1.27e-01 | 0.0889 |
90293 | KLHL13 | P9T-E | Human | Esophagus | ESCC | 2.40e-12 | 2.88e-01 | 0.1131 |
90293 | KLHL13 | P10T-E | Human | Esophagus | ESCC | 8.73e-14 | 1.42e-01 | 0.116 |
90293 | KLHL13 | P12T-E | Human | Esophagus | ESCC | 2.64e-14 | 3.01e-01 | 0.1122 |
90293 | KLHL13 | P15T-E | Human | Esophagus | ESCC | 1.25e-06 | 1.77e-01 | 0.1149 |
90293 | KLHL13 | P16T-E | Human | Esophagus | ESCC | 8.57e-06 | 8.75e-02 | 0.1153 |
90293 | KLHL13 | P20T-E | Human | Esophagus | ESCC | 7.12e-05 | 1.70e-01 | 0.1124 |
90293 | KLHL13 | P21T-E | Human | Esophagus | ESCC | 3.73e-09 | 2.09e-01 | 0.1617 |
90293 | KLHL13 | P22T-E | Human | Esophagus | ESCC | 9.29e-09 | 1.84e-01 | 0.1236 |
90293 | KLHL13 | P23T-E | Human | Esophagus | ESCC | 1.37e-18 | 4.29e-01 | 0.108 |
90293 | KLHL13 | P24T-E | Human | Esophagus | ESCC | 2.56e-03 | 6.59e-02 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00513021 | Cervix | CC | regulation of cell division | 39/2311 | 177/18723 | 2.05e-04 | 2.33e-03 | 39 |
GO:00009107 | Cervix | CC | cytokinesis | 37/2311 | 173/18723 | 5.40e-04 | 5.23e-03 | 37 |
GO:0032465 | Cervix | CC | regulation of cytokinesis | 22/2311 | 92/18723 | 1.55e-03 | 1.20e-02 | 22 |
GO:000091016 | Esophagus | ESCC | cytokinesis | 115/8552 | 173/18723 | 2.48e-08 | 4.68e-07 | 115 |
GO:00324653 | Esophagus | ESCC | regulation of cytokinesis | 57/8552 | 92/18723 | 1.20e-03 | 5.88e-03 | 57 |
GO:00513025 | Esophagus | ESCC | regulation of cell division | 97/8552 | 177/18723 | 8.93e-03 | 3.12e-02 | 97 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412014 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0412015 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLHL13 | SNV | Missense_Mutation | c.484N>G | p.Leu162Val | p.L162V | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-EJ-5511-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | ||
KLHL13 | SNV | Missense_Mutation | rs774910888 | c.350N>G | p.Ser117Cys | p.S117C | protein_coding | deleterious(0) | benign(0.034) | TCGA-BR-4253-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
KLHL13 | SNV | Missense_Mutation | c.364N>C | p.Phe122Leu | p.F122L | protein_coding | tolerated(0.08) | possibly_damaging(0.47) | TCGA-BR-4280-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
KLHL13 | SNV | Missense_Mutation | c.1808G>A | p.Arg603His | p.R603H | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-BR-6705-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
KLHL13 | SNV | Missense_Mutation | c.740N>G | p.Leu247Arg | p.L247R | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8286-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
KLHL13 | SNV | Missense_Mutation | c.1300N>T | p.Arg434Cys | p.R434C | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | ||
KLHL13 | SNV | Missense_Mutation | novel | c.1255C>G | p.Pro419Ala | p.P419A | protein_coding | deleterious(0.02) | probably_damaging(0.981) | TCGA-VQ-A8DV-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
KLHL13 | SNV | Missense_Mutation | novel | c.1957T>A | p.Ser653Thr | p.S653T | protein_coding | tolerated(0.3) | probably_damaging(0.961) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | |
KLHL13 | SNV | Missense_Mutation | novel | c.1815G>T | p.Met605Ile | p.M605I | protein_coding | tolerated(0.43) | possibly_damaging(0.631) | TCGA-DJ-A3VF-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KLHL13 | insertion | In_Frame_Ins | novel | c.1813_1814insACTACAGCATCTTAG | p.Met605delinsAsnTyrSerIleLeuVal | p.M605delinsNYSILV | protein_coding | TCGA-DJ-A3VF-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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