GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004325422 | Liver | HCC | regulation of protein-containing complex assembly | 264/7958 | 428/18723 | 5.47e-16 | 4.39e-14 | 264 |
GO:005125822 | Liver | HCC | protein polymerization | 182/7958 | 297/18723 | 4.17e-11 | 1.58e-09 | 182 |
GO:190290322 | Liver | HCC | regulation of supramolecular fiber organization | 224/7958 | 383/18723 | 1.54e-10 | 5.33e-09 | 224 |
GO:000701522 | Liver | HCC | actin filament organization | 252/7958 | 442/18723 | 3.83e-10 | 1.25e-08 | 252 |
GO:001063912 | Liver | HCC | negative regulation of organelle organization | 204/7958 | 348/18723 | 7.67e-10 | 2.37e-08 | 204 |
GO:003253522 | Liver | HCC | regulation of cellular component size | 217/7958 | 383/18723 | 1.28e-08 | 3.14e-07 | 217 |
GO:003227122 | Liver | HCC | regulation of protein polymerization | 141/7958 | 233/18723 | 2.00e-08 | 4.72e-07 | 141 |
GO:003297022 | Liver | HCC | regulation of actin filament-based process | 222/7958 | 397/18723 | 3.81e-08 | 8.30e-07 | 222 |
GO:003295622 | Liver | HCC | regulation of actin cytoskeleton organization | 202/7958 | 358/18723 | 6.18e-08 | 1.29e-06 | 202 |
GO:003133312 | Liver | HCC | negative regulation of protein-containing complex assembly | 91/7958 | 141/18723 | 1.01e-07 | 1.98e-06 | 91 |
GO:000815422 | Liver | HCC | actin polymerization or depolymerization | 130/7958 | 218/18723 | 2.31e-07 | 4.14e-06 | 130 |
GO:003004122 | Liver | HCC | actin filament polymerization | 116/7958 | 191/18723 | 2.66e-07 | 4.68e-06 | 116 |
GO:011005322 | Liver | HCC | regulation of actin filament organization | 158/7958 | 278/18723 | 9.01e-07 | 1.37e-05 | 158 |
GO:003083212 | Liver | HCC | regulation of actin filament length | 113/7958 | 189/18723 | 1.16e-06 | 1.71e-05 | 113 |
GO:003083322 | Liver | HCC | regulation of actin filament polymerization | 104/7958 | 172/18723 | 1.46e-06 | 2.08e-05 | 104 |
GO:000806412 | Liver | HCC | regulation of actin polymerization or depolymerization | 112/7958 | 188/18723 | 1.65e-06 | 2.31e-05 | 112 |
GO:190290412 | Liver | HCC | negative regulation of supramolecular fiber organization | 90/7958 | 167/18723 | 1.90e-03 | 9.69e-03 | 90 |
GO:003227212 | Liver | HCC | negative regulation of protein polymerization | 46/7958 | 80/18723 | 4.81e-03 | 2.03e-02 | 46 |
GO:00514946 | Liver | HCC | negative regulation of cytoskeleton organization | 84/7958 | 163/18723 | 1.22e-02 | 4.43e-02 | 84 |
GO:003083712 | Liver | HCC | negative regulation of actin filament polymerization | 37/7958 | 65/18723 | 1.33e-02 | 4.77e-02 | 37 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KANK4 | SNV | Missense_Mutation | rs752600367 | c.2719N>A | p.Asp907Asn | p.D907N | Q5T7N3 | protein_coding | deleterious(0.01) | possibly_damaging(0.905) | TCGA-37-3783-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
KANK4 | SNV | Missense_Mutation | novel | c.1732N>A | p.Leu578Met | p.L578M | Q5T7N3 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KANK4 | SNV | Missense_Mutation | | c.331C>G | p.Pro111Ala | p.P111A | Q5T7N3 | protein_coding | tolerated(0.21) | benign(0.026) | TCGA-63-6202-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
KANK4 | SNV | Missense_Mutation | novel | c.32C>T | p.Ser11Phe | p.S11F | Q5T7N3 | protein_coding | tolerated(0.18) | benign(0.007) | TCGA-63-A5MP-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
KANK4 | SNV | Missense_Mutation | novel | c.352N>C | p.Ala118Pro | p.A118P | Q5T7N3 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-85-8350-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KANK4 | SNV | Missense_Mutation | rs770551628 | c.2792N>T | p.Ser931Leu | p.S931L | Q5T7N3 | protein_coding | deleterious(0) | possibly_damaging(0.874) | TCGA-85-A4QQ-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KANK4 | SNV | Missense_Mutation | novel | c.1873N>A | p.Pro625Thr | p.P625T | Q5T7N3 | protein_coding | tolerated(1) | benign(0.044) | TCGA-85-A511-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
KANK4 | SNV | Missense_Mutation | novel | c.644N>C | p.Ser215Thr | p.S215T | Q5T7N3 | protein_coding | tolerated(0.16) | benign(0.06) | TCGA-90-A59Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
KANK4 | SNV | Missense_Mutation | novel | c.2062N>C | p.Glu688Gln | p.E688Q | Q5T7N3 | protein_coding | deleterious(0.01) | possibly_damaging(0.756) | TCGA-NC-A5HG-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR |
KANK4 | SNV | Missense_Mutation | rs867539814 | c.241N>T | p.Arg81Cys | p.R81C | Q5T7N3 | protein_coding | tolerated(0.05) | possibly_damaging(0.72) | TCGA-BB-A5HZ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |