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Gene: IREB2 |
Gene summary for IREB2 |
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Gene information | Species | Human | Gene symbol | IREB2 | Gene ID | 3658 |
Gene name | iron responsive element binding protein 2 | |
Gene Alias | ACO3 | |
Cytomap | 15q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | P48200 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3658 | IREB2 | LZE4T | Human | Esophagus | ESCC | 1.90e-12 | 3.21e-01 | 0.0811 |
3658 | IREB2 | LZE5T | Human | Esophagus | ESCC | 4.08e-04 | 3.13e-01 | 0.0514 |
3658 | IREB2 | LZE7T | Human | Esophagus | ESCC | 7.78e-19 | 6.98e-01 | 0.0667 |
3658 | IREB2 | LZE8T | Human | Esophagus | ESCC | 5.52e-06 | 2.61e-01 | 0.067 |
3658 | IREB2 | LZE20T | Human | Esophagus | ESCC | 2.73e-04 | 7.69e-02 | 0.0662 |
3658 | IREB2 | LZE24T | Human | Esophagus | ESCC | 3.83e-11 | 2.35e-01 | 0.0596 |
3658 | IREB2 | LZE21T | Human | Esophagus | ESCC | 2.45e-04 | 2.89e-01 | 0.0655 |
3658 | IREB2 | LZE6T | Human | Esophagus | ESCC | 1.27e-04 | 1.59e-01 | 0.0845 |
3658 | IREB2 | P1T-E | Human | Esophagus | ESCC | 4.01e-05 | 3.87e-01 | 0.0875 |
3658 | IREB2 | P2T-E | Human | Esophagus | ESCC | 1.27e-20 | 3.27e-01 | 0.1177 |
3658 | IREB2 | P4T-E | Human | Esophagus | ESCC | 7.50e-17 | 4.58e-01 | 0.1323 |
3658 | IREB2 | P5T-E | Human | Esophagus | ESCC | 5.56e-07 | 1.49e-01 | 0.1327 |
3658 | IREB2 | P8T-E | Human | Esophagus | ESCC | 1.95e-20 | 4.86e-01 | 0.0889 |
3658 | IREB2 | P9T-E | Human | Esophagus | ESCC | 9.88e-16 | 3.76e-01 | 0.1131 |
3658 | IREB2 | P10T-E | Human | Esophagus | ESCC | 1.89e-37 | 6.59e-01 | 0.116 |
3658 | IREB2 | P11T-E | Human | Esophagus | ESCC | 2.92e-07 | 2.18e-01 | 0.1426 |
3658 | IREB2 | P12T-E | Human | Esophagus | ESCC | 5.52e-30 | 5.74e-01 | 0.1122 |
3658 | IREB2 | P15T-E | Human | Esophagus | ESCC | 8.71e-24 | 5.78e-01 | 0.1149 |
3658 | IREB2 | P16T-E | Human | Esophagus | ESCC | 1.75e-24 | 4.95e-01 | 0.1153 |
3658 | IREB2 | P19T-E | Human | Esophagus | ESCC | 1.68e-02 | 3.87e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:0045333110 | Esophagus | ESCC | cellular respiration | 173/8552 | 230/18723 | 4.53e-20 | 5.99e-18 | 173 |
GO:0009060110 | Esophagus | ESCC | aerobic respiration | 145/8552 | 189/18723 | 2.16e-18 | 2.21e-16 | 145 |
GO:0015980110 | Esophagus | ESCC | energy derivation by oxidation of organic compounds | 220/8552 | 318/18723 | 1.20e-17 | 1.09e-15 | 220 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:0030099111 | Esophagus | ESCC | myeloid cell differentiation | 232/8552 | 381/18723 | 1.22e-09 | 2.90e-08 | 232 |
GO:0002262111 | Esophagus | ESCC | myeloid cell homeostasis | 104/8552 | 157/18723 | 1.49e-07 | 2.36e-06 | 104 |
GO:0034101111 | Esophagus | ESCC | erythrocyte homeostasis | 88/8552 | 129/18723 | 1.81e-07 | 2.84e-06 | 88 |
GO:00060997 | Esophagus | ESCC | tricarboxylic acid cycle | 27/8552 | 30/18723 | 4.54e-07 | 6.15e-06 | 27 |
GO:0048872111 | Esophagus | ESCC | homeostasis of number of cells | 163/8552 | 272/18723 | 1.40e-06 | 1.69e-05 | 163 |
GO:000257317 | Esophagus | ESCC | myeloid leukocyte differentiation | 128/8552 | 208/18723 | 2.75e-06 | 3.15e-05 | 128 |
GO:00097919 | Esophagus | ESCC | post-embryonic development | 56/8552 | 80/18723 | 9.08e-06 | 8.71e-05 | 56 |
GO:005507617 | Esophagus | ESCC | transition metal ion homeostasis | 87/8552 | 138/18723 | 2.85e-05 | 2.37e-04 | 87 |
GO:00469169 | Esophagus | ESCC | cellular transition metal ion homeostasis | 70/8552 | 115/18723 | 7.28e-04 | 3.79e-03 | 70 |
GO:00067791 | Esophagus | ESCC | porphyrin-containing compound biosynthetic process | 23/8552 | 31/18723 | 1.20e-03 | 5.88e-03 | 23 |
GO:00330141 | Esophagus | ESCC | tetrapyrrole biosynthetic process | 23/8552 | 31/18723 | 1.20e-03 | 5.88e-03 | 23 |
GO:00461482 | Esophagus | ESCC | pigment biosynthetic process | 40/8552 | 62/18723 | 2.14e-03 | 9.54e-03 | 40 |
GO:00723503 | Esophagus | ESCC | tricarboxylic acid metabolic process | 12/8552 | 14/18723 | 2.51e-03 | 1.08e-02 | 12 |
GO:00067832 | Esophagus | ESCC | heme biosynthetic process | 20/8552 | 27/18723 | 2.61e-03 | 1.11e-02 | 20 |
GO:00550729 | Esophagus | ESCC | iron ion homeostasis | 52/8552 | 85/18723 | 2.86e-03 | 1.21e-02 | 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IREB2 | deletion | Frame_Shift_Del | novel | c.2415delT | p.Phe805LeufsTer21 | p.F805Lfs*21 | protein_coding | TCGA-V1-A9Z7-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |||
IREB2 | SNV | Missense_Mutation | rs746547492 | c.1771G>A | p.Ala591Thr | p.A591T | protein_coding | tolerated(0.38) | benign(0.237) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IREB2 | SNV | Missense_Mutation | c.25N>A | p.Ala9Thr | p.A9T | protein_coding | tolerated(0.31) | benign(0.003) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
IREB2 | SNV | Missense_Mutation | c.95N>A | p.Gly32Asp | p.G32D | protein_coding | tolerated(0.53) | probably_damaging(1) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
IREB2 | SNV | Missense_Mutation | rs867914053 | c.299C>T | p.Ala100Val | p.A100V | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | |
IREB2 | SNV | Missense_Mutation | rs755226126 | c.1609N>T | p.Arg537Cys | p.R537C | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR | |
IREB2 | SNV | Missense_Mutation | c.85T>C | p.Ser29Pro | p.S29P | protein_coding | tolerated(1) | benign(0) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
IREB2 | SNV | Missense_Mutation | rs553171458 | c.1561N>G | p.Met521Val | p.M521V | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
IREB2 | SNV | Missense_Mutation | rs375120202 | c.2879N>A | p.Arg960Gln | p.R960Q | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
IREB2 | SNV | Missense_Mutation | c.367N>T | p.Asp123Tyr | p.D123Y | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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