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Gene: GALNT8 |
Gene summary for GALNT8 |
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Gene information | Species | Human | Gene symbol | GALNT8 | Gene ID | 26290 |
Gene name | polypeptide N-acetylgalactosaminyltransferase 8 | |
Gene Alias | GALNAC-T8 | |
Cytomap | 12p13.32 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9NY28 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26290 | GALNT8 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.72e-03 | 6.66e-01 | -0.1088 |
26290 | GALNT8 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.24e-08 | 5.96e-01 | -0.1464 |
26290 | GALNT8 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.49e-08 | 5.90e-01 | -0.1001 |
26290 | GALNT8 | A002-C-116 | Human | Colorectum | FAP | 1.27e-03 | 3.69e-01 | -0.0452 |
26290 | GALNT8 | C38 | Human | Oral cavity | OSCC | 3.10e-09 | 6.62e-01 | 0.172 |
26290 | GALNT8 | C06 | Human | Oral cavity | OSCC | 1.28e-06 | 4.91e-01 | 0.2699 |
26290 | GALNT8 | LN38 | Human | Oral cavity | OSCC | 2.78e-08 | 7.90e-01 | 0.168 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006486 | Colorectum | AD | protein glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0043413 | Colorectum | AD | macromolecule glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0070085 | Colorectum | AD | glycosylation | 67/3918 | 240/18723 | 5.78e-03 | 3.67e-02 | 67 |
GO:00064861 | Colorectum | FAP | protein glycosylation | 48/2622 | 226/18723 | 1.85e-03 | 1.57e-02 | 48 |
GO:00434131 | Colorectum | FAP | macromolecule glycosylation | 48/2622 | 226/18723 | 1.85e-03 | 1.57e-02 | 48 |
GO:00700851 | Colorectum | FAP | glycosylation | 50/2622 | 240/18723 | 2.30e-03 | 1.85e-02 | 50 |
GO:0009101 | Colorectum | FAP | glycoprotein biosynthetic process | 63/2622 | 317/18723 | 2.31e-03 | 1.86e-02 | 63 |
GO:00091001 | Oral cavity | OSCC | glycoprotein metabolic process | 185/7305 | 387/18723 | 2.37e-04 | 1.54e-03 | 185 |
GO:00091011 | Oral cavity | OSCC | glycoprotein biosynthetic process | 151/7305 | 317/18723 | 1.01e-03 | 5.26e-03 | 151 |
GO:00064864 | Oral cavity | OSCC | protein glycosylation | 111/7305 | 226/18723 | 1.22e-03 | 6.10e-03 | 111 |
GO:00434134 | Oral cavity | OSCC | macromolecule glycosylation | 111/7305 | 226/18723 | 1.22e-03 | 6.10e-03 | 111 |
GO:00700853 | Oral cavity | OSCC | glycosylation | 117/7305 | 240/18723 | 1.29e-03 | 6.42e-03 | 117 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GALNT8 | SNV | Missense_Mutation | rs144271473 | c.1648N>T | p.Ala550Ser | p.A550S | Q9NY28 | protein_coding | tolerated(0.64) | benign(0.173) | TCGA-46-3767-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GALNT8 | SNV | Missense_Mutation | novel | c.70C>T | p.Leu24Phe | p.L24F | Q9NY28 | protein_coding | tolerated_low_confidence(0.2) | benign(0.003) | TCGA-60-2696-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GALNT8 | SNV | Missense_Mutation | novel | c.1250A>T | p.Tyr417Phe | p.Y417F | Q9NY28 | protein_coding | deleterious(0) | possibly_damaging(0.548) | TCGA-77-8156-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GALNT8 | SNV | Missense_Mutation | novel | c.1338N>T | p.Leu446Phe | p.L446F | Q9NY28 | protein_coding | tolerated(0.27) | benign(0.015) | TCGA-85-7843-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GALNT8 | SNV | Missense_Mutation | novel | c.980N>A | p.Phe327Tyr | p.F327Y | Q9NY28 | protein_coding | tolerated(0.18) | probably_damaging(1) | TCGA-96-8169-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GALNT8 | SNV | Missense_Mutation | c.1016C>G | p.Pro339Arg | p.P339R | Q9NY28 | protein_coding | tolerated(0.13) | benign(0.317) | TCGA-96-A4JK-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | CR | |
GALNT8 | SNV | Missense_Mutation | novel | c.1174N>T | p.Val392Leu | p.V392L | Q9NY28 | protein_coding | deleterious(0) | possibly_damaging(0.746) | TCGA-O2-A52V-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GALNT8 | SNV | Missense_Mutation | novel | c.423G>C | p.Gln141His | p.Q141H | Q9NY28 | protein_coding | tolerated(0.06) | possibly_damaging(0.564) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
GALNT8 | SNV | Missense_Mutation | c.434N>A | p.Arg145Gln | p.R145Q | Q9NY28 | protein_coding | tolerated(1) | benign(0) | TCGA-CQ-5332-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
GALNT8 | SNV | Missense_Mutation | novel | c.976N>A | p.Gly326Arg | p.G326R | Q9NY28 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-CV-7432-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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