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Gene: FKBP15 |
Gene summary for FKBP15 |
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Gene information | Species | Human | Gene symbol | FKBP15 | Gene ID | 23307 |
Gene name | FKBP prolyl isomerase family member 15 | |
Gene Alias | FKBP133 | |
Cytomap | 9q32 | |
Gene Type | protein-coding | GO ID | GO:0000413 | UniProtAcc | Q5T1M5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23307 | FKBP15 | LZE4T | Human | Esophagus | ESCC | 6.63e-05 | 2.03e-01 | 0.0811 |
23307 | FKBP15 | LZE7T | Human | Esophagus | ESCC | 3.51e-03 | 1.47e-01 | 0.0667 |
23307 | FKBP15 | LZE20T | Human | Esophagus | ESCC | 1.15e-08 | 2.62e-01 | 0.0662 |
23307 | FKBP15 | LZE24T | Human | Esophagus | ESCC | 3.60e-11 | 2.23e-01 | 0.0596 |
23307 | FKBP15 | P1T-E | Human | Esophagus | ESCC | 3.92e-03 | 2.12e-01 | 0.0875 |
23307 | FKBP15 | P2T-E | Human | Esophagus | ESCC | 1.12e-24 | 3.29e-01 | 0.1177 |
23307 | FKBP15 | P4T-E | Human | Esophagus | ESCC | 3.49e-16 | 2.68e-01 | 0.1323 |
23307 | FKBP15 | P5T-E | Human | Esophagus | ESCC | 2.60e-21 | 3.71e-01 | 0.1327 |
23307 | FKBP15 | P8T-E | Human | Esophagus | ESCC | 4.71e-11 | 1.37e-01 | 0.0889 |
23307 | FKBP15 | P9T-E | Human | Esophagus | ESCC | 1.10e-05 | 1.40e-01 | 0.1131 |
23307 | FKBP15 | P10T-E | Human | Esophagus | ESCC | 4.38e-12 | 2.26e-01 | 0.116 |
23307 | FKBP15 | P11T-E | Human | Esophagus | ESCC | 3.72e-12 | 4.36e-01 | 0.1426 |
23307 | FKBP15 | P12T-E | Human | Esophagus | ESCC | 5.14e-06 | 1.79e-01 | 0.1122 |
23307 | FKBP15 | P15T-E | Human | Esophagus | ESCC | 1.21e-16 | 2.76e-01 | 0.1149 |
23307 | FKBP15 | P16T-E | Human | Esophagus | ESCC | 5.93e-08 | 1.29e-01 | 0.1153 |
23307 | FKBP15 | P17T-E | Human | Esophagus | ESCC | 8.55e-05 | 1.93e-01 | 0.1278 |
23307 | FKBP15 | P20T-E | Human | Esophagus | ESCC | 5.50e-07 | 1.61e-01 | 0.1124 |
23307 | FKBP15 | P21T-E | Human | Esophagus | ESCC | 7.22e-20 | 2.90e-01 | 0.1617 |
23307 | FKBP15 | P22T-E | Human | Esophagus | ESCC | 1.36e-09 | 1.03e-01 | 0.1236 |
23307 | FKBP15 | P23T-E | Human | Esophagus | ESCC | 4.28e-14 | 1.70e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001820816 | Esophagus | ESCC | peptidyl-proline modification | 46/8552 | 58/18723 | 1.59e-07 | 2.51e-06 | 46 |
GO:000041313 | Esophagus | ESCC | protein peptidyl-prolyl isomerization | 32/8552 | 42/18723 | 5.52e-05 | 4.27e-04 | 32 |
GO:00182088 | Oral cavity | OSCC | peptidyl-proline modification | 42/7305 | 58/18723 | 2.49e-07 | 3.92e-06 | 42 |
GO:00004134 | Oral cavity | OSCC | protein peptidyl-prolyl isomerization | 28/7305 | 42/18723 | 2.61e-04 | 1.67e-03 | 28 |
GO:001820810 | Skin | cSCC | peptidyl-proline modification | 37/4864 | 58/18723 | 1.53e-09 | 5.82e-08 | 37 |
GO:00004136 | Skin | cSCC | protein peptidyl-prolyl isomerization | 26/4864 | 42/18723 | 9.92e-07 | 1.78e-05 | 26 |
GO:001820817 | Thyroid | PTC | peptidyl-proline modification | 42/5968 | 58/18723 | 2.71e-10 | 8.91e-09 | 42 |
GO:00004137 | Thyroid | PTC | protein peptidyl-prolyl isomerization | 30/5968 | 42/18723 | 1.65e-07 | 3.13e-06 | 30 |
GO:001820818 | Thyroid | ATC | peptidyl-proline modification | 42/6293 | 58/18723 | 1.70e-09 | 4.21e-08 | 42 |
GO:000041314 | Thyroid | ATC | protein peptidyl-prolyl isomerization | 30/6293 | 42/18723 | 6.06e-07 | 8.44e-06 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FKBP15 | SNV | Missense_Mutation | rs769214308 | c.37C>T | p.Leu13Phe | p.L13F | Q5T1M5 | protein_coding | deleterious(0.01) | possibly_damaging(0.641) | TCGA-BA-4076-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
FKBP15 | SNV | Missense_Mutation | rs375150301 | c.1072N>A | p.Asp358Asn | p.D358N | Q5T1M5 | protein_coding | deleterious(0.05) | probably_damaging(0.998) | TCGA-BA-5152-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FKBP15 | SNV | Missense_Mutation | novel | c.1948G>T | p.Ala650Ser | p.A650S | Q5T1M5 | protein_coding | tolerated(0.23) | possibly_damaging(0.515) | TCGA-BA-6869-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
FKBP15 | SNV | Missense_Mutation | novel | c.1995N>T | p.Lys665Asn | p.K665N | Q5T1M5 | protein_coding | deleterious(0) | possibly_damaging(0.598) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
FKBP15 | SNV | Missense_Mutation | novel | c.989C>T | p.Ser330Leu | p.S330L | Q5T1M5 | protein_coding | deleterious(0.04) | benign(0.223) | TCGA-CV-A6K1-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FKBP15 | SNV | Missense_Mutation | c.548N>G | p.Ser183Cys | p.S183C | Q5T1M5 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-EJ-8470-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
FKBP15 | SNV | Missense_Mutation | rs368555848 | c.2485G>A | p.Ala829Thr | p.A829T | Q5T1M5 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
FKBP15 | SNV | Missense_Mutation | c.1018C>G | p.Leu340Val | p.L340V | Q5T1M5 | protein_coding | tolerated(0.95) | benign(0.038) | TCGA-BR-7717-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
FKBP15 | SNV | Missense_Mutation | rs199849054 | c.1802N>A | p.Arg601Gln | p.R601Q | Q5T1M5 | protein_coding | tolerated(0.31) | benign(0.14) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
FKBP15 | SNV | Missense_Mutation | rs771241869 | c.607N>A | p.Ala203Thr | p.A203T | Q5T1M5 | protein_coding | deleterious(0.03) | probably_damaging(0.965) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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