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Gene: FAM65B |
Gene summary for FAM65B |
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Gene information | Species | Human | Gene symbol | FAM65B | Gene ID | 9750 |
Gene name | RHO family interacting cell polarization regulator 2 | |
Gene Alias | C6orf32 | |
Cytomap | 6p22.3 | |
Gene Type | protein-coding | GO ID | GO:0000768 | UniProtAcc | B7Z5J9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9750 | FAM65B | HCC1 | Human | Liver | HCC | 2.38e-20 | 1.98e+00 | 0.5336 |
9750 | FAM65B | HCC2 | Human | Liver | HCC | 1.13e-38 | 3.10e+00 | 0.5341 |
9750 | FAM65B | HCC5 | Human | Liver | HCC | 1.76e-71 | 3.43e+00 | 0.4932 |
9750 | FAM65B | Dong_P1 | Human | Prostate | Tumor | 4.27e-02 | 5.06e-02 | 0.035 |
9750 | FAM65B | Dong_P3 | Human | Prostate | Tumor | 2.85e-07 | 1.28e-01 | 0.0278 |
9750 | FAM65B | P7 | Human | Prostate | Tumor | 1.67e-02 | 2.54e-01 | -0.1025 |
9750 | FAM65B | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 3.71e-02 | 5.52e-01 | 0.159 |
9750 | FAM65B | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 2.78e-04 | 2.86e-01 | 0.1633 |
9750 | FAM65B | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 4.96e-07 | 3.36e-01 | 0.1621 |
9750 | FAM65B | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 3.41e-03 | 4.31e-01 | 0.1619 |
9750 | FAM65B | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 5.40e-10 | 5.31e-01 | 0.1602 |
9750 | FAM65B | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 5.78e-05 | 4.28e-01 | 0.1608 |
9750 | FAM65B | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 3.09e-16 | 5.97e-01 | 0.1575 |
9750 | FAM65B | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 4.84e-16 | 6.19e-01 | 0.1545 |
9750 | FAM65B | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 1.16e-18 | 7.45e-01 | 0.1569 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease | ||
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM65B | SNV | Missense_Mutation | novel | c.115A>T | p.Ile39Phe | p.I39F | Q9Y4F9 | protein_coding | deleterious(0.01) | possibly_damaging(0.853) | TCGA-3K-AAZ8-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | sorafenib | PD |
FAM65B | SNV | Missense_Mutation | novel | c.361N>A | p.Gln121Lys | p.Q121K | Q9Y4F9 | protein_coding | deleterious(0) | possibly_damaging(0.555) | TCGA-ED-A82E-01 | Liver | liver hepatocellular carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM65B | SNV | Missense_Mutation | rs769663089 | c.1789N>G | p.Arg597Gly | p.R597G | Q9Y4F9 | protein_coding | tolerated(0.14) | possibly_damaging(0.574) | TCGA-KR-A7K8-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FAM65B | SNV | Missense_Mutation | novel | c.1198N>T | p.Pro400Ser | p.P400S | Q9Y4F9 | protein_coding | tolerated(0.7) | benign(0.121) | TCGA-XR-A8TF-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FAM65B | deletion | Frame_Shift_Del | novel | c.1152delC | p.Lys385SerfsTer22 | p.K385Sfs*22 | Q9Y4F9 | protein_coding | TCGA-CC-A3MC-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | ||
FAM65B | SNV | Missense_Mutation | c.1296C>A | p.Ser432Arg | p.S432R | Q9Y4F9 | protein_coding | deleterious(0.03) | possibly_damaging(0.668) | TCGA-05-4415-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
FAM65B | SNV | Missense_Mutation | c.1906N>C | p.Asp636His | p.D636H | Q9Y4F9 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-44-2656-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
FAM65B | SNV | Missense_Mutation | c.1585N>C | p.Glu529Gln | p.E529Q | Q9Y4F9 | protein_coding | tolerated(0.24) | benign(0.068) | TCGA-44-3396-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | alimta | SD | |
FAM65B | SNV | Missense_Mutation | c.1608T>A | p.Asp536Glu | p.D536E | Q9Y4F9 | protein_coding | tolerated(0.82) | benign(0.047) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
FAM65B | SNV | Missense_Mutation | c.1020G>A | p.Met340Ile | p.M340I | Q9Y4F9 | protein_coding | tolerated(0.37) | benign(0.21) | TCGA-44-6776-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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