|
Gene: FAM135A |
Gene summary for FAM135A |
Gene summary. |
Gene information | Species | Human | Gene symbol | FAM135A | Gene ID | 57579 |
Gene name | family with sequence similarity 135 member A | |
Gene Alias | KIAA1411 | |
Cytomap | 6q13 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q9P2D6 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57579 | FAM135A | CCI_1 | Human | Cervix | CC | 2.39e-10 | 1.14e+00 | 0.528 |
57579 | FAM135A | CCI_2 | Human | Cervix | CC | 1.56e-06 | 1.04e+00 | 0.5249 |
57579 | FAM135A | CCI_3 | Human | Cervix | CC | 2.58e-07 | 6.73e-01 | 0.516 |
57579 | FAM135A | T3 | Human | Cervix | CC | 4.58e-03 | 1.14e-01 | 0.1389 |
57579 | FAM135A | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.70e-36 | -8.57e-01 | 0.0155 |
57579 | FAM135A | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.14e-03 | -4.68e-01 | -0.1808 |
57579 | FAM135A | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.28e-05 | -9.02e-01 | 0.0216 |
57579 | FAM135A | HTA11_347_2000001011 | Human | Colorectum | AD | 2.72e-02 | 3.92e-01 | -0.1954 |
57579 | FAM135A | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.61e-15 | -7.55e-01 | -0.1207 |
57579 | FAM135A | HTA11_696_2000001011 | Human | Colorectum | AD | 3.22e-09 | -4.22e-01 | -0.1464 |
57579 | FAM135A | HTA11_866_2000001011 | Human | Colorectum | AD | 5.28e-03 | -3.11e-01 | -0.1001 |
57579 | FAM135A | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.01e-03 | -5.92e-01 | -0.1462 |
57579 | FAM135A | HTA11_9341_2000001011 | Human | Colorectum | SER | 9.78e-05 | -8.98e-01 | -0.00410000000000005 |
57579 | FAM135A | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.04e-05 | -5.83e-01 | -0.0179 |
57579 | FAM135A | HTA11_866_3004761011 | Human | Colorectum | AD | 1.54e-31 | -8.45e-01 | 0.096 |
57579 | FAM135A | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.26e-02 | -7.13e-01 | 0.0446 |
57579 | FAM135A | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.45e-05 | -8.15e-01 | 0.0451 |
57579 | FAM135A | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.88e-07 | -7.69e-01 | 0.0528 |
57579 | FAM135A | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.00e-06 | -7.95e-01 | 0.0131 |
57579 | FAM135A | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.40e-02 | -6.32e-01 | 0.0171 |
Page: 1 2 3 4 5 6 7 8 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM135A | SNV | Missense_Mutation | novel | c.293N>T | p.Arg98Ile | p.R98I | Q9P2D6 | protein_coding | deleterious(0) | benign(0.122) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM135A | SNV | Missense_Mutation | novel | c.3938N>C | p.Ile1313Thr | p.I1313T | Q9P2D6 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM135A | SNV | Missense_Mutation | novel | c.3434N>A | p.Pro1145His | p.P1145H | Q9P2D6 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM135A | SNV | Missense_Mutation | novel | c.4204N>G | p.Leu1402Val | p.L1402V | Q9P2D6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
FAM135A | SNV | Missense_Mutation | novel | c.688N>A | p.Ala230Thr | p.A230T | Q9P2D6 | protein_coding | tolerated(0.06) | benign(0.254) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
FAM135A | SNV | Missense_Mutation | rs749262279 | c.3479N>A | p.Arg1160Gln | p.R1160Q | Q9P2D6 | protein_coding | deleterious(0.01) | possibly_damaging(0.895) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
FAM135A | SNV | Missense_Mutation | novel | c.4026N>G | p.Phe1342Leu | p.F1342L | Q9P2D6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM135A | SNV | Missense_Mutation | novel | c.1747A>C | p.Thr583Pro | p.T583P | Q9P2D6 | protein_coding | deleterious(0.04) | benign(0.368) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM135A | SNV | Missense_Mutation | novel | c.306A>C | p.Glu102Asp | p.E102D | Q9P2D6 | protein_coding | tolerated(0.21) | probably_damaging(0.978) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM135A | SNV | Missense_Mutation | rs766369291 | c.3572C>T | p.Ser1191Leu | p.S1191L | Q9P2D6 | protein_coding | deleterious(0.03) | benign(0.288) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |