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Gene: EFR3A |
Gene summary for EFR3A |
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Gene information | Species | Human | Gene symbol | EFR3A | Gene ID | 23167 |
Gene name | EFR3 homolog A | |
Gene Alias | EFR3A | |
Cytomap | 8q24.22 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q14156 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23167 | EFR3A | LZE4T | Human | Esophagus | ESCC | 3.98e-20 | 5.96e-01 | 0.0811 |
23167 | EFR3A | LZE8T | Human | Esophagus | ESCC | 1.11e-02 | 6.35e-02 | 0.067 |
23167 | EFR3A | LZE20T | Human | Esophagus | ESCC | 5.11e-04 | 2.88e-01 | 0.0662 |
23167 | EFR3A | LZE22T | Human | Esophagus | ESCC | 1.78e-02 | 2.43e-01 | 0.068 |
23167 | EFR3A | LZE24T | Human | Esophagus | ESCC | 8.95e-13 | 2.62e-01 | 0.0596 |
23167 | EFR3A | LZE21T | Human | Esophagus | ESCC | 9.52e-03 | 2.07e-01 | 0.0655 |
23167 | EFR3A | P1T-E | Human | Esophagus | ESCC | 4.55e-06 | 3.06e-01 | 0.0875 |
23167 | EFR3A | P2T-E | Human | Esophagus | ESCC | 2.75e-24 | 5.03e-01 | 0.1177 |
23167 | EFR3A | P4T-E | Human | Esophagus | ESCC | 1.72e-19 | 5.13e-01 | 0.1323 |
23167 | EFR3A | P5T-E | Human | Esophagus | ESCC | 2.25e-22 | 4.55e-01 | 0.1327 |
23167 | EFR3A | P8T-E | Human | Esophagus | ESCC | 1.88e-21 | 4.73e-01 | 0.0889 |
23167 | EFR3A | P9T-E | Human | Esophagus | ESCC | 9.53e-17 | 3.92e-01 | 0.1131 |
23167 | EFR3A | P10T-E | Human | Esophagus | ESCC | 1.77e-22 | 3.39e-01 | 0.116 |
23167 | EFR3A | P11T-E | Human | Esophagus | ESCC | 6.95e-11 | 6.13e-01 | 0.1426 |
23167 | EFR3A | P12T-E | Human | Esophagus | ESCC | 2.16e-56 | 1.04e+00 | 0.1122 |
23167 | EFR3A | P15T-E | Human | Esophagus | ESCC | 4.76e-33 | 8.08e-01 | 0.1149 |
23167 | EFR3A | P16T-E | Human | Esophagus | ESCC | 9.26e-31 | 6.03e-01 | 0.1153 |
23167 | EFR3A | P17T-E | Human | Esophagus | ESCC | 2.94e-09 | 5.76e-01 | 0.1278 |
23167 | EFR3A | P19T-E | Human | Esophagus | ESCC | 2.82e-08 | 6.75e-01 | 0.1662 |
23167 | EFR3A | P20T-E | Human | Esophagus | ESCC | 1.69e-18 | 4.97e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072659110 | Esophagus | ESCC | protein localization to plasma membrane | 193/8552 | 284/18723 | 1.95e-14 | 1.03e-12 | 193 |
GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
GO:00086544 | Esophagus | ESCC | phospholipid biosynthetic process | 162/8552 | 253/18723 | 2.59e-09 | 5.73e-08 | 162 |
GO:00464744 | Esophagus | ESCC | glycerophospholipid biosynthetic process | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:00450175 | Esophagus | ESCC | glycerolipid biosynthetic process | 154/8552 | 252/18723 | 5.20e-07 | 6.96e-06 | 154 |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
GO:00066505 | Esophagus | ESCC | glycerophospholipid metabolic process | 174/8552 | 306/18723 | 4.92e-05 | 3.85e-04 | 174 |
GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
GO:00066611 | Esophagus | ESCC | phosphatidylinositol biosynthetic process | 73/8552 | 131/18723 | 1.31e-02 | 4.28e-02 | 73 |
GO:00464863 | Liver | NAFLD | glycerolipid metabolic process | 66/1882 | 392/18723 | 1.94e-05 | 5.52e-04 | 66 |
GO:00726597 | Liver | NAFLD | protein localization to plasma membrane | 51/1882 | 284/18723 | 2.97e-05 | 7.83e-04 | 51 |
GO:19907786 | Liver | NAFLD | protein localization to cell periphery | 56/1882 | 333/18723 | 8.29e-05 | 1.69e-03 | 56 |
GO:00450174 | Liver | NAFLD | glycerolipid biosynthetic process | 43/1882 | 252/18723 | 3.83e-04 | 5.73e-03 | 43 |
GO:00464742 | Liver | NAFLD | glycerophospholipid biosynthetic process | 33/1882 | 211/18723 | 6.93e-03 | 4.88e-02 | 33 |
GO:007265921 | Liver | HCC | protein localization to plasma membrane | 177/7958 | 284/18723 | 1.02e-11 | 4.18e-10 | 177 |
GO:199077821 | Liver | HCC | protein localization to cell periphery | 200/7958 | 333/18723 | 6.07e-11 | 2.23e-09 | 200 |
GO:00086542 | Liver | HCC | phospholipid biosynthetic process | 150/7958 | 253/18723 | 4.77e-08 | 1.03e-06 | 150 |
GO:00066444 | Liver | HCC | phospholipid metabolic process | 214/7958 | 383/18723 | 7.25e-08 | 1.48e-06 | 214 |
GO:004648611 | Liver | HCC | glycerolipid metabolic process | 215/7958 | 392/18723 | 4.54e-07 | 7.49e-06 | 215 |
GO:004501711 | Liver | HCC | glycerolipid biosynthetic process | 143/7958 | 252/18723 | 3.27e-06 | 4.31e-05 | 143 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EFR3A | SNV | Missense_Mutation | rs778434355 | c.1781N>A | p.Arg594His | p.R594H | Q14156 | protein_coding | deleterious(0.01) | probably_damaging(0.955) | TCGA-CD-8528-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | CR |
EFR3A | SNV | Missense_Mutation | c.880C>G | p.Gln294Glu | p.Q294E | Q14156 | protein_coding | tolerated(0.44) | benign(0.143) | TCGA-CG-4477-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
EFR3A | SNV | Missense_Mutation | c.1169N>A | p.Gly390Glu | p.G390E | Q14156 | protein_coding | deleterious(0) | possibly_damaging(0.908) | TCGA-D7-A74A-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
EFR3A | SNV | Missense_Mutation | c.2199A>T | p.Lys733Asn | p.K733N | Q14156 | protein_coding | tolerated(0.13) | benign(0.044) | TCGA-FP-A4BF-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
EFR3A | SNV | Missense_Mutation | rs774325452 | c.640N>T | p.Arg214Cys | p.R214C | Q14156 | protein_coding | deleterious(0.01) | possibly_damaging(0.736) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
EFR3A | deletion | Frame_Shift_Del | novel | c.1071delN | p.Gly359AspfsTer3 | p.G359Dfs*3 | Q14156 | protein_coding | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
EFR3A | deletion | Frame_Shift_Del | novel | c.2181_2188delNNNNNNNN | p.Phe728IlefsTer6 | p.F728Ifs*6 | Q14156 | protein_coding | TCGA-IN-7806-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | epirubicin | CR | ||
EFR3A | SNV | Missense_Mutation | c.1994N>C | p.Ile665Thr | p.I665T | Q14156 | protein_coding | deleterious(0) | possibly_damaging(0.894) | TCGA-J8-A3YE-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EFR3A | insertion | Nonsense_Mutation | novel | c.752_753insATAAAGAAAAACACAAGAATTT | p.Asn251LysfsTer2 | p.N251Kfs*2 | Q14156 | protein_coding | TCGA-E8-A436-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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