![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DISP2 |
Gene summary for DISP2 |
![]() |
Gene information | Species | Human | Gene symbol | DISP2 | Gene ID | 85455 |
Gene name | dispatched RND transporter family member 2 | |
Gene Alias | C15orf36 | |
Cytomap | 15q15.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | A7MBM2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85455 | DISP2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.37e-11 | 4.01e-01 | -0.1808 |
85455 | DISP2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.70e-02 | 1.44e-01 | -0.1088 |
85455 | DISP2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.76e-02 | 1.01e-01 | -0.1954 |
85455 | DISP2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.40e-05 | 3.50e-01 | -0.1464 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DISP2 | deletion | Frame_Shift_Del | novel | c.1623delC | p.Phe542SerfsTer10 | p.F542Sfs*10 | A7MBM2 | protein_coding | TCGA-43-5668-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Other, specify in notesMAGE3-AS15-NSC-003 | clinical | PD | ||
DISP2 | SNV | Missense_Mutation | novel | c.2854N>A | p.Glu952Lys | p.E952K | A7MBM2 | protein_coding | tolerated(0.05) | benign(0.085) | TCGA-CQ-5331-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DISP2 | SNV | Missense_Mutation | novel | c.215N>T | p.Pro72Leu | p.P72L | A7MBM2 | protein_coding | deleterious_low_confidence(0.01) | benign(0.127) | TCGA-CV-6940-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DISP2 | SNV | Missense_Mutation | novel | c.3812N>T | p.Pro1271Leu | p.P1271L | A7MBM2 | protein_coding | deleterious(0.01) | possibly_damaging(0.663) | TCGA-CV-7099-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DISP2 | SNV | Missense_Mutation | novel | c.2176N>A | p.Arg726Ser | p.R726S | A7MBM2 | protein_coding | deleterious(0.04) | possibly_damaging(0.618) | TCGA-CV-7263-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
DISP2 | SNV | Missense_Mutation | novel | c.617N>C | p.Arg206Pro | p.R206P | A7MBM2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HD-A4C1-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DISP2 | SNV | Missense_Mutation | c.813C>A | p.Asp271Glu | p.D271E | A7MBM2 | protein_coding | tolerated(0.1) | benign(0.009) | TCGA-TN-A7HJ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
DISP2 | insertion | Frame_Shift_Ins | novel | c.1483_1484insAGGGCAGGGAGGGAGAGGAA | p.Ala495GlufsTer64 | p.A495Efs*64 | A7MBM2 | protein_coding | TCGA-CH-5761-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | ||
DISP2 | SNV | Missense_Mutation | novel | c.1522N>T | p.Arg508Cys | p.R508C | A7MBM2 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-B7-A5TI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | eloxatin | CR |
DISP2 | SNV | Missense_Mutation | rs763352261 | c.3151N>T | p.Arg1051Cys | p.R1051C | A7MBM2 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |