![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CPXM2 |
Gene summary for CPXM2 |
![]() |
Gene information | Species | Human | Gene symbol | CPXM2 | Gene ID | 119587 |
Gene name | carboxypeptidase X, M14 family member 2 | |
Gene Alias | CPX2 | |
Cytomap | 10q26.13 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q8N436 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
119587 | CPXM2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.65e-12 | 1.33e+00 | 0.0131 |
119587 | CPXM2 | A008-E-015 | Human | Colorectum | FAP | 5.77e-03 | 2.58e-01 | 0.0177 |
119587 | CPXM2 | P2T-E | Human | Esophagus | ESCC | 6.44e-05 | 1.62e-01 | 0.1177 |
119587 | CPXM2 | P4T-E | Human | Esophagus | ESCC | 1.05e-10 | 1.67e-01 | 0.1323 |
119587 | CPXM2 | P15T-E | Human | Esophagus | ESCC | 4.63e-03 | 8.85e-02 | 0.1149 |
119587 | CPXM2 | P16T-E | Human | Esophagus | ESCC | 1.24e-51 | 8.80e-01 | 0.1153 |
119587 | CPXM2 | P26T-E | Human | Esophagus | ESCC | 2.15e-14 | 4.36e-01 | 0.1276 |
119587 | CPXM2 | P27T-E | Human | Esophagus | ESCC | 5.12e-47 | 7.66e-01 | 0.1055 |
119587 | CPXM2 | P30T-E | Human | Esophagus | ESCC | 6.29e-12 | 4.10e-01 | 0.137 |
119587 | CPXM2 | P47T-E | Human | Esophagus | ESCC | 4.38e-02 | 4.18e-02 | 0.1067 |
119587 | CPXM2 | P48T-E | Human | Esophagus | ESCC | 4.77e-05 | 2.39e-01 | 0.0959 |
119587 | CPXM2 | P57T-E | Human | Esophagus | ESCC | 8.09e-05 | 2.74e-01 | 0.0926 |
119587 | CPXM2 | P74T-E | Human | Esophagus | ESCC | 3.51e-13 | 4.01e-01 | 0.1479 |
119587 | CPXM2 | P76T-E | Human | Esophagus | ESCC | 1.07e-15 | 3.44e-01 | 0.1207 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00516041 | Colorectum | SER | protein maturation | 73/2897 | 294/18723 | 1.82e-05 | 5.38e-04 | 73 |
GO:00164851 | Colorectum | SER | protein processing | 55/2897 | 225/18723 | 2.84e-04 | 4.67e-03 | 55 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPXM2 | SNV | Missense_Mutation | c.1359N>A | p.Asn453Lys | p.N453K | Q8N436 | protein_coding | deleterious(0.04) | benign(0.232) | TCGA-55-7570-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CPXM2 | SNV | Missense_Mutation | c.1618N>T | p.Thr540Ser | p.T540S | Q8N436 | protein_coding | tolerated(0.47) | benign(0.014) | TCGA-55-8208-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CPXM2 | SNV | Missense_Mutation | novel | c.308A>G | p.Lys103Arg | p.K103R | Q8N436 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.956) | TCGA-55-A491-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CPXM2 | SNV | Missense_Mutation | c.1470N>C | p.Glu490Asp | p.E490D | Q8N436 | protein_coding | tolerated(0.08) | benign(0.036) | TCGA-62-8399-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
CPXM2 | SNV | Missense_Mutation | c.1392G>T | p.Trp464Cys | p.W464C | Q8N436 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-78-7542-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CPXM2 | SNV | Missense_Mutation | novel | c.710N>C | p.Val237Ala | p.V237A | Q8N436 | protein_coding | tolerated(0.11) | benign(0.338) | TCGA-86-8673-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
CPXM2 | SNV | Missense_Mutation | c.671N>G | p.Ser224Cys | p.S224C | Q8N436 | protein_coding | deleterious(0) | probably_damaging(0.937) | TCGA-93-A4JN-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | belinostat | SD | |
CPXM2 | SNV | Missense_Mutation | novel | c.550N>A | p.Trp184Arg | p.W184R | Q8N436 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-97-8179-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CPXM2 | SNV | Missense_Mutation | c.314G>A | p.Ser105Asn | p.S105N | Q8N436 | protein_coding | tolerated_low_confidence(0.31) | benign(0.023) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
CPXM2 | SNV | Missense_Mutation | rs765152743 | c.1976C>T | p.Ala659Val | p.A659V | Q8N436 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-37-4130-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |