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Gene: COPB1 |
Gene summary for COPB1 |
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Gene information | Species | Human | Gene symbol | COPB1 | Gene ID | 1315 |
Gene name | COPI coat complex subunit beta 1 | |
Gene Alias | BARMACS | |
Cytomap | 11p15.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | P53618 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1315 | COPB1 | LZE2T | Human | Esophagus | ESCC | 8.84e-08 | 5.71e-01 | 0.082 |
1315 | COPB1 | LZE4T | Human | Esophagus | ESCC | 1.50e-12 | 4.63e-01 | 0.0811 |
1315 | COPB1 | LZE7T | Human | Esophagus | ESCC | 1.44e-06 | 8.15e-01 | 0.0667 |
1315 | COPB1 | LZE20T | Human | Esophagus | ESCC | 1.65e-06 | 1.24e-01 | 0.0662 |
1315 | COPB1 | LZE24T | Human | Esophagus | ESCC | 1.78e-16 | 5.28e-01 | 0.0596 |
1315 | COPB1 | LZE6T | Human | Esophagus | ESCC | 7.26e-04 | 2.44e-01 | 0.0845 |
1315 | COPB1 | P1T-E | Human | Esophagus | ESCC | 1.78e-06 | 2.94e-01 | 0.0875 |
1315 | COPB1 | P2T-E | Human | Esophagus | ESCC | 1.62e-32 | 4.86e-01 | 0.1177 |
1315 | COPB1 | P4T-E | Human | Esophagus | ESCC | 5.67e-20 | 5.35e-01 | 0.1323 |
1315 | COPB1 | P5T-E | Human | Esophagus | ESCC | 9.30e-06 | 1.49e-01 | 0.1327 |
1315 | COPB1 | P8T-E | Human | Esophagus | ESCC | 6.07e-22 | 3.19e-01 | 0.0889 |
1315 | COPB1 | P9T-E | Human | Esophagus | ESCC | 6.65e-07 | 2.90e-01 | 0.1131 |
1315 | COPB1 | P10T-E | Human | Esophagus | ESCC | 4.36e-26 | 5.80e-01 | 0.116 |
1315 | COPB1 | P11T-E | Human | Esophagus | ESCC | 9.99e-09 | 6.46e-01 | 0.1426 |
1315 | COPB1 | P12T-E | Human | Esophagus | ESCC | 1.05e-43 | 7.78e-01 | 0.1122 |
1315 | COPB1 | P15T-E | Human | Esophagus | ESCC | 1.47e-17 | 5.09e-01 | 0.1149 |
1315 | COPB1 | P16T-E | Human | Esophagus | ESCC | 2.58e-23 | 4.57e-01 | 0.1153 |
1315 | COPB1 | P17T-E | Human | Esophagus | ESCC | 1.75e-07 | 6.38e-01 | 0.1278 |
1315 | COPB1 | P20T-E | Human | Esophagus | ESCC | 2.65e-14 | 4.11e-01 | 0.1124 |
1315 | COPB1 | P21T-E | Human | Esophagus | ESCC | 2.37e-37 | 7.49e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:000688815 | Esophagus | ESCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 102/8552 | 130/18723 | 1.73e-14 | 9.22e-13 | 102 |
GO:00068914 | Esophagus | ESCC | intra-Golgi vesicle-mediated transport | 26/8552 | 33/18723 | 1.06e-04 | 7.43e-04 | 26 |
GO:004819311 | Liver | Cirrhotic | Golgi vesicle transport | 153/4634 | 296/18723 | 1.02e-23 | 6.43e-21 | 153 |
GO:000688811 | Liver | Cirrhotic | endoplasmic reticulum to Golgi vesicle-mediated transport | 77/4634 | 130/18723 | 5.78e-17 | 7.56e-15 | 77 |
GO:004819321 | Liver | HCC | Golgi vesicle transport | 217/7958 | 296/18723 | 2.58e-27 | 1.02e-24 | 217 |
GO:000688821 | Liver | HCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 100/7958 | 130/18723 | 1.15e-15 | 8.67e-14 | 100 |
GO:0006891 | Liver | HCC | intra-Golgi vesicle-mediated transport | 22/7958 | 33/18723 | 4.38e-03 | 1.90e-02 | 22 |
GO:004819315 | Oral cavity | OSCC | Golgi vesicle transport | 209/7305 | 296/18723 | 1.39e-28 | 6.30e-26 | 209 |
GO:00068888 | Oral cavity | OSCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 97/7305 | 130/18723 | 1.42e-16 | 1.15e-14 | 97 |
GO:00068913 | Oral cavity | OSCC | intra-Golgi vesicle-mediated transport | 23/7305 | 33/18723 | 3.47e-04 | 2.12e-03 | 23 |
GO:004819310 | Prostate | BPH | Golgi vesicle transport | 102/3107 | 296/18723 | 3.90e-14 | 4.56e-12 | 102 |
GO:00068887 | Prostate | BPH | endoplasmic reticulum to Golgi vesicle-mediated transport | 46/3107 | 130/18723 | 1.53e-07 | 3.53e-06 | 46 |
GO:00068912 | Prostate | BPH | intra-Golgi vesicle-mediated transport | 12/3107 | 33/18723 | 4.90e-03 | 2.32e-02 | 12 |
GO:004819314 | Prostate | Tumor | Golgi vesicle transport | 105/3246 | 296/18723 | 3.55e-14 | 4.33e-12 | 105 |
GO:000688813 | Prostate | Tumor | endoplasmic reticulum to Golgi vesicle-mediated transport | 49/3246 | 130/18723 | 2.49e-08 | 8.33e-07 | 49 |
GO:00068911 | Prostate | Tumor | intra-Golgi vesicle-mediated transport | 12/3246 | 33/18723 | 7.03e-03 | 3.16e-02 | 12 |
GO:0048193110 | Skin | cSCC | Golgi vesicle transport | 153/4864 | 296/18723 | 1.85e-21 | 3.41e-19 | 153 |
GO:000688810 | Skin | cSCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 73/4864 | 130/18723 | 2.60e-13 | 1.57e-11 | 73 |
GO:000689112 | Skin | cSCC | intra-Golgi vesicle-mediated transport | 18/4864 | 33/18723 | 4.45e-04 | 3.42e-03 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COPB1 | insertion | Nonsense_Mutation | novel | c.2806_2807insGGCTATAAATTAT | p.Met936ArgfsTer3 | p.M936Rfs*3 | P53618 | protein_coding | TCGA-HD-8635-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
COPB1 | SNV | Missense_Mutation | rs781094064 | c.1771A>G | p.Thr591Ala | p.T591A | P53618 | protein_coding | tolerated(0.08) | benign(0) | TCGA-EJ-7782-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD |
COPB1 | SNV | Missense_Mutation | c.1835G>A | p.Arg612Gln | p.R612Q | P53618 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
COPB1 | SNV | Missense_Mutation | rs142993682 | c.1699C>T | p.Arg567Cys | p.R567C | P53618 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
COPB1 | SNV | Missense_Mutation | c.998N>G | p.Asp333Gly | p.D333G | P53618 | protein_coding | deleterious(0.04) | benign(0.139) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COPB1 | SNV | Missense_Mutation | rs776682426 | c.731N>A | p.Arg244His | p.R244H | P53618 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COPB1 | SNV | Missense_Mutation | rs145451352 | c.1289G>A | p.Arg430His | p.R430H | P53618 | protein_coding | deleterious(0.01) | probably_damaging(0.953) | TCGA-BR-8368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COPB1 | SNV | Missense_Mutation | rs780242730 | c.842N>T | p.Ala281Val | p.A281V | P53618 | protein_coding | deleterious(0.03) | probably_damaging(0.984) | TCGA-D7-6817-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5 fluorouracilum+leucovorin | SD |
COPB1 | SNV | Missense_Mutation | c.130A>G | p.Lys44Glu | p.K44E | P53618 | protein_coding | tolerated(0.08) | possibly_damaging(0.513) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
COPB1 | SNV | Missense_Mutation | rs777777654 | c.880N>A | p.Asp294Asn | p.D294N | P53618 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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