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Gene: CLUH |
Gene summary for CLUH |
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Gene information | Species | Human | Gene symbol | CLUH | Gene ID | 23277 |
Gene name | clustered mitochondria homolog | |
Gene Alias | CLU1 | |
Cytomap | 17p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | O75153 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23277 | CLUH | HTA11_347_2000001011 | Human | Colorectum | AD | 3.85e-02 | 2.37e-01 | -0.1954 |
23277 | CLUH | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.26e-03 | 4.15e-01 | -0.059 |
23277 | CLUH | HTA11_866_3004761011 | Human | Colorectum | AD | 2.91e-06 | 3.68e-01 | 0.096 |
23277 | CLUH | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.33e-02 | 3.73e-01 | 0.0131 |
23277 | CLUH | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.51e-02 | 6.11e-01 | 0.0171 |
23277 | CLUH | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.35e-04 | 2.99e-01 | 0.0674 |
23277 | CLUH | A015-C-203 | Human | Colorectum | FAP | 2.56e-14 | 4.28e-01 | -0.1294 |
23277 | CLUH | A015-C-204 | Human | Colorectum | FAP | 9.99e-05 | 4.86e-01 | -0.0228 |
23277 | CLUH | A014-C-040 | Human | Colorectum | FAP | 3.77e-02 | 5.21e-01 | -0.1184 |
23277 | CLUH | A002-C-205 | Human | Colorectum | FAP | 1.86e-04 | 7.49e-02 | -0.1236 |
23277 | CLUH | A015-C-006 | Human | Colorectum | FAP | 5.33e-07 | 4.03e-01 | -0.0994 |
23277 | CLUH | A015-C-106 | Human | Colorectum | FAP | 4.21e-04 | 2.05e-01 | -0.0511 |
23277 | CLUH | A002-C-114 | Human | Colorectum | FAP | 2.29e-04 | 1.99e-01 | -0.1561 |
23277 | CLUH | A015-C-104 | Human | Colorectum | FAP | 2.11e-11 | 3.00e-01 | -0.1899 |
23277 | CLUH | A015-C-202 | Human | Colorectum | FAP | 2.90e-03 | 3.45e-01 | -0.0849 |
23277 | CLUH | A002-C-016 | Human | Colorectum | FAP | 9.27e-04 | -1.94e-02 | 0.0521 |
23277 | CLUH | A015-C-002 | Human | Colorectum | FAP | 1.31e-03 | 3.17e-01 | -0.0763 |
23277 | CLUH | A002-C-116 | Human | Colorectum | FAP | 3.90e-07 | -5.53e-02 | -0.0452 |
23277 | CLUH | A014-C-008 | Human | Colorectum | FAP | 2.47e-03 | 2.57e-01 | -0.191 |
23277 | CLUH | A018-E-020 | Human | Colorectum | FAP | 9.69e-03 | 6.02e-02 | -0.2034 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00516463 | Esophagus | ESCC | mitochondrion localization | 35/8552 | 50/18723 | 4.33e-04 | 2.44e-03 | 35 |
GO:0051646 | Liver | HCC | mitochondrion localization | 34/7958 | 50/18723 | 2.38e-04 | 1.79e-03 | 34 |
GO:0048311 | Liver | HCC | mitochondrion distribution | 12/7958 | 16/18723 | 8.74e-03 | 3.40e-02 | 12 |
GO:00516462 | Oral cavity | OSCC | mitochondrion localization | 28/7305 | 50/18723 | 1.10e-02 | 3.72e-02 | 28 |
GO:005164611 | Skin | cSCC | mitochondrion localization | 22/4864 | 50/18723 | 4.31e-03 | 2.27e-02 | 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLUH | SNV | Missense_Mutation | c.664G>A | p.Gly222Arg | p.G222R | O75153 | protein_coding | deleterious(0.01) | possibly_damaging(0.749) | TCGA-DD-A1EF-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
CLUH | SNV | Missense_Mutation | c.1769G>T | p.Arg590Leu | p.R590L | O75153 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-55-8302-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CLUH | SNV | Missense_Mutation | c.3306N>C | p.Glu1102Asp | p.E1102D | O75153 | protein_coding | tolerated(0.2) | benign(0.05) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CLUH | SNV | Missense_Mutation | rs747122833 | c.3262G>T | p.Ala1088Ser | p.A1088S | O75153 | protein_coding | deleterious(0.02) | probably_damaging(0.974) | TCGA-78-7158-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
CLUH | SNV | Missense_Mutation | c.1124G>T | p.Arg375Leu | p.R375L | O75153 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-78-7166-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CLUH | SNV | Missense_Mutation | novel | c.1405A>G | p.Thr469Ala | p.T469A | O75153 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
CLUH | SNV | Missense_Mutation | novel | c.3884C>T | p.Ser1295Phe | p.S1295F | O75153 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.485) | TCGA-L9-A444-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLUH | SNV | Missense_Mutation | rs756743030 | c.1369N>T | p.Arg457Cys | p.R457C | O75153 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
CLUH | SNV | Missense_Mutation | c.2456N>T | p.Arg819Leu | p.R819L | O75153 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-34-5232-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLUH | SNV | Missense_Mutation | novel | c.3746G>T | p.Ser1249Ile | p.S1249I | O75153 | protein_coding | deleterious(0) | possibly_damaging(0.851) | TCGA-92-8063-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | taxol | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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