![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CACHD1 |
Gene summary for CACHD1 |
![]() |
Gene information | Species | Human | Gene symbol | CACHD1 | Gene ID | 57685 |
Gene name | cache domain containing 1 | |
Gene Alias | CACHD1 | |
Cytomap | 1p31.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q5VU97 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57685 | CACHD1 | AEH-subject1 | Human | Endometrium | AEH | 6.22e-12 | 3.93e-01 | -0.3059 |
57685 | CACHD1 | AEH-subject2 | Human | Endometrium | AEH | 2.36e-06 | 3.14e-01 | -0.2525 |
57685 | CACHD1 | AEH-subject3 | Human | Endometrium | AEH | 1.52e-14 | 4.95e-01 | -0.2576 |
57685 | CACHD1 | AEH-subject4 | Human | Endometrium | AEH | 1.82e-08 | 4.51e-01 | -0.2657 |
57685 | CACHD1 | AEH-subject5 | Human | Endometrium | AEH | 1.41e-05 | 3.78e-01 | -0.2953 |
57685 | CACHD1 | EEC-subject1 | Human | Endometrium | EEC | 3.19e-14 | 5.16e-01 | -0.2682 |
57685 | CACHD1 | EEC-subject2 | Human | Endometrium | EEC | 8.90e-07 | 3.38e-01 | -0.2607 |
57685 | CACHD1 | EEC-subject3 | Human | Endometrium | EEC | 1.46e-03 | 1.97e-01 | -0.2525 |
57685 | CACHD1 | EEC-subject4 | Human | Endometrium | EEC | 7.11e-06 | 3.04e-01 | -0.2571 |
57685 | CACHD1 | EEC-subject5 | Human | Endometrium | EEC | 3.94e-06 | 3.15e-01 | -0.249 |
57685 | CACHD1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 6.56e-09 | 3.76e-02 | -0.1869 |
57685 | CACHD1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.55e-06 | -1.45e-02 | -0.1875 |
57685 | CACHD1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.11e-10 | 1.13e-01 | -0.1883 |
57685 | CACHD1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 4.18e-04 | 1.01e-01 | -0.1934 |
57685 | CACHD1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 9.36e-07 | -3.64e-02 | -0.1917 |
57685 | CACHD1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.83e-10 | -4.13e-02 | -0.1916 |
57685 | CACHD1 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 3.37e-02 | 2.16e-01 | -0.1269 |
57685 | CACHD1 | HCC2 | Human | Liver | HCC | 1.41e-05 | 3.64e+00 | 0.5341 |
57685 | CACHD1 | S014 | Human | Liver | HCC | 6.93e-25 | 7.43e-01 | 0.2254 |
57685 | CACHD1 | S015 | Human | Liver | HCC | 3.28e-20 | 9.28e-01 | 0.2375 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006816 | Lung | AIS | calcium ion transport | 58/1849 | 422/18723 | 6.08e-03 | 4.98e-02 | 58 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CACHD1 | SNV | Missense_Mutation | novel | c.1929C>A | p.Asn643Lys | p.N643K | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CACHD1 | SNV | Missense_Mutation | c.2817N>T | p.Glu939Asp | p.E939D | protein_coding | tolerated(0.24) | probably_damaging(0.931) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
CACHD1 | SNV | Missense_Mutation | rs760611986 | c.3266N>A | p.Arg1089His | p.R1089H | protein_coding | deleterious(0.01) | probably_damaging(0.976) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CACHD1 | SNV | Missense_Mutation | novel | c.535G>T | p.Val179Leu | p.V179L | protein_coding | tolerated(0.12) | possibly_damaging(0.846) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CACHD1 | SNV | Missense_Mutation | c.3115A>G | p.Met1039Val | p.M1039V | protein_coding | tolerated(0.38) | benign(0.354) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CACHD1 | SNV | Missense_Mutation | novel | c.2341G>A | p.Gly781Ser | p.G781S | protein_coding | tolerated_low_confidence(0.16) | benign(0.142) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
CACHD1 | SNV | Missense_Mutation | novel | c.931N>A | p.Leu311Ile | p.L311I | protein_coding | tolerated(0.1) | probably_damaging(0.931) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CACHD1 | SNV | Missense_Mutation | c.2393N>T | p.Ala798Val | p.A798V | protein_coding | tolerated(0.09) | probably_damaging(0.989) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CACHD1 | SNV | Missense_Mutation | novel | c.2468N>C | p.Val823Ala | p.V823A | protein_coding | tolerated(0.07) | possibly_damaging(0.9) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CACHD1 | SNV | Missense_Mutation | rs772296106 | c.308N>A | p.Arg103Gln | p.R103Q | protein_coding | tolerated(0.48) | probably_damaging(0.968) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |