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Gene: C5orf42 |
Gene summary for C5ORF42 |
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Gene information | Species | Human | Gene symbol | C5orf42 | Gene ID | 65250 |
Gene name | ciliogenesis and planar polarity effector 1 | |
Gene Alias | C5orf42 | |
Cytomap | 5p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q9H799 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65250 | C5orf42 | P1T-E | Human | Esophagus | ESCC | 1.07e-08 | 3.86e-01 | 0.0875 |
65250 | C5orf42 | P2T-E | Human | Esophagus | ESCC | 1.23e-20 | 3.46e-01 | 0.1177 |
65250 | C5orf42 | P4T-E | Human | Esophagus | ESCC | 3.57e-05 | 1.74e-01 | 0.1323 |
65250 | C5orf42 | P5T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.11e-01 | 0.1327 |
65250 | C5orf42 | P8T-E | Human | Esophagus | ESCC | 1.80e-26 | 4.12e-01 | 0.0889 |
65250 | C5orf42 | P9T-E | Human | Esophagus | ESCC | 7.32e-04 | 1.60e-01 | 0.1131 |
65250 | C5orf42 | P10T-E | Human | Esophagus | ESCC | 1.25e-26 | 5.20e-01 | 0.116 |
65250 | C5orf42 | P11T-E | Human | Esophagus | ESCC | 1.54e-08 | 4.24e-01 | 0.1426 |
65250 | C5orf42 | P12T-E | Human | Esophagus | ESCC | 5.68e-24 | 4.09e-01 | 0.1122 |
65250 | C5orf42 | P15T-E | Human | Esophagus | ESCC | 5.32e-05 | 1.12e-01 | 0.1149 |
65250 | C5orf42 | P16T-E | Human | Esophagus | ESCC | 2.48e-11 | 2.54e-01 | 0.1153 |
65250 | C5orf42 | P20T-E | Human | Esophagus | ESCC | 4.64e-11 | 2.39e-01 | 0.1124 |
65250 | C5orf42 | P21T-E | Human | Esophagus | ESCC | 1.59e-15 | 2.02e-01 | 0.1617 |
65250 | C5orf42 | P22T-E | Human | Esophagus | ESCC | 4.16e-22 | 3.14e-01 | 0.1236 |
65250 | C5orf42 | P23T-E | Human | Esophagus | ESCC | 4.63e-02 | 1.20e-01 | 0.108 |
65250 | C5orf42 | P24T-E | Human | Esophagus | ESCC | 7.31e-07 | 8.04e-02 | 0.1287 |
65250 | C5orf42 | P26T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.23e-01 | 0.1276 |
65250 | C5orf42 | P27T-E | Human | Esophagus | ESCC | 3.88e-18 | 3.14e-01 | 0.1055 |
65250 | C5orf42 | P28T-E | Human | Esophagus | ESCC | 1.88e-16 | 3.32e-01 | 0.1149 |
65250 | C5orf42 | P30T-E | Human | Esophagus | ESCC | 1.32e-13 | 4.65e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C5orf42 | SNV | Missense_Mutation | rs760263591 | c.7376G>A | p.Arg2459Lys | p.R2459K | Q9H799 | protein_coding | tolerated(0.07) | benign(0.007) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C5orf42 | SNV | Missense_Mutation | novel | c.7193G>T | p.Arg2398Ile | p.R2398I | Q9H799 | protein_coding | deleterious(0.05) | benign(0.147) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C5orf42 | SNV | Missense_Mutation | c.3356T>C | p.Val1119Ala | p.V1119A | Q9H799 | protein_coding | tolerated(0.19) | benign(0.063) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C5orf42 | SNV | Missense_Mutation | c.7387N>T | p.Asp2463Tyr | p.D2463Y | Q9H799 | protein_coding | deleterious(0.01) | possibly_damaging(0.855) | TCGA-AG-A025-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C5orf42 | SNV | Missense_Mutation | c.1948N>C | p.Asp650His | p.D650H | Q9H799 | protein_coding | tolerated(0.3) | possibly_damaging(0.799) | TCGA-AH-6544-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
C5orf42 | SNV | Missense_Mutation | c.3811N>T | p.Gly1271Cys | p.G1271C | Q9H799 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
C5orf42 | SNV | Missense_Mutation | novel | c.5374N>A | p.Glu1792Lys | p.E1792K | Q9H799 | protein_coding | tolerated(0.07) | benign(0.027) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
C5orf42 | SNV | Missense_Mutation | rs752334335 | c.3748N>A | p.Ala1250Thr | p.A1250T | Q9H799 | protein_coding | tolerated(0.05) | benign(0.014) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
C5orf42 | SNV | Missense_Mutation | novel | c.5201N>A | p.Pro1734His | p.P1734H | Q9H799 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C5orf42 | SNV | Missense_Mutation | novel | c.4659N>A | p.Phe1553Leu | p.F1553L | Q9H799 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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