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Gene: BCR |
Gene summary for BCR |
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Gene information | Species | Human | Gene symbol | BCR | Gene ID | 613 |
Gene name | BCR activator of RhoGEF and GTPase | |
Gene Alias | ALL | |
Cytomap | 22q11.23 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | P11274 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
613 | BCR | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.34e-05 | 3.87e-01 | 0.0155 |
613 | BCR | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.40e-08 | 8.14e-01 | -0.0811 |
613 | BCR | HTA11_347_2000001011 | Human | Colorectum | AD | 1.68e-02 | 3.19e-01 | -0.1954 |
613 | BCR | HTA11_411_2000001011 | Human | Colorectum | SER | 1.63e-05 | 1.03e+00 | -0.2602 |
613 | BCR | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.25e-05 | 6.01e-01 | -0.1207 |
613 | BCR | HTA11_83_2000001011 | Human | Colorectum | SER | 2.63e-06 | 7.65e-01 | -0.1526 |
613 | BCR | HTA11_696_2000001011 | Human | Colorectum | AD | 1.49e-25 | 1.02e+00 | -0.1464 |
613 | BCR | HTA11_866_2000001011 | Human | Colorectum | AD | 7.28e-03 | 3.74e-01 | -0.1001 |
613 | BCR | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.13e-04 | 5.44e-01 | -0.059 |
613 | BCR | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.30e-07 | 1.03e+00 | -0.1706 |
613 | BCR | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.26e-07 | 8.79e-01 | -0.2061 |
613 | BCR | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.55e-05 | 9.51e-01 | -0.1462 |
613 | BCR | HTA11_546_2000001011 | Human | Colorectum | AD | 1.11e-11 | 1.06e+00 | -0.0842 |
613 | BCR | A015-C-203 | Human | Colorectum | FAP | 3.77e-12 | -1.68e-01 | -0.1294 |
613 | BCR | A002-C-201 | Human | Colorectum | FAP | 4.04e-04 | -7.30e-02 | 0.0324 |
613 | BCR | A001-C-119 | Human | Colorectum | FAP | 2.74e-02 | -1.01e-01 | -0.1557 |
613 | BCR | A001-C-108 | Human | Colorectum | FAP | 2.41e-05 | -1.36e-01 | -0.0272 |
613 | BCR | A002-C-205 | Human | Colorectum | FAP | 1.67e-09 | -2.09e-01 | -0.1236 |
613 | BCR | A015-C-006 | Human | Colorectum | FAP | 1.07e-06 | -1.45e-01 | -0.0994 |
613 | BCR | A015-C-106 | Human | Colorectum | FAP | 1.69e-04 | -2.11e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0150115 | Colorectum | AD | cell-substrate junction organization | 44/3918 | 101/18723 | 2.38e-07 | 9.81e-06 | 44 |
GO:0031589 | Colorectum | AD | cell-substrate adhesion | 116/3918 | 363/18723 | 4.68e-07 | 1.76e-05 | 116 |
GO:0007044 | Colorectum | AD | cell-substrate junction assembly | 41/3918 | 95/18723 | 8.20e-07 | 2.85e-05 | 41 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:0046777 | Colorectum | AD | protein autophosphorylation | 74/3918 | 227/18723 | 2.48e-05 | 4.76e-04 | 74 |
GO:0007160 | Colorectum | AD | cell-matrix adhesion | 75/3918 | 233/18723 | 3.56e-05 | 6.45e-04 | 75 |
GO:0048041 | Colorectum | AD | focal adhesion assembly | 34/3918 | 87/18723 | 8.30e-05 | 1.30e-03 | 34 |
GO:0043547 | Colorectum | AD | positive regulation of GTPase activity | 75/3918 | 255/18723 | 7.95e-04 | 7.91e-03 | 75 |
GO:0046578 | Colorectum | AD | regulation of Ras protein signal transduction | 56/3918 | 189/18723 | 2.85e-03 | 2.14e-02 | 56 |
GO:0007266 | Colorectum | AD | Rho protein signal transduction | 42/3918 | 137/18723 | 4.64e-03 | 3.16e-02 | 42 |
GO:0009913 | Colorectum | AD | epidermal cell differentiation | 58/3918 | 202/18723 | 5.16e-03 | 3.42e-02 | 58 |
GO:0008544 | Colorectum | AD | epidermis development | 87/3918 | 324/18723 | 5.99e-03 | 3.76e-02 | 87 |
GO:00343291 | Colorectum | SER | cell junction assembly | 100/2897 | 420/18723 | 4.23e-06 | 1.61e-04 | 100 |
GO:01501151 | Colorectum | SER | cell-substrate junction organization | 34/2897 | 101/18723 | 4.46e-06 | 1.67e-04 | 34 |
GO:00467771 | Colorectum | SER | protein autophosphorylation | 60/2897 | 227/18723 | 1.36e-05 | 4.25e-04 | 60 |
GO:00070441 | Colorectum | SER | cell-substrate junction assembly | 31/2897 | 95/18723 | 2.34e-05 | 6.64e-04 | 31 |
GO:00315891 | Colorectum | SER | cell-substrate adhesion | 86/2897 | 363/18723 | 2.36e-05 | 6.64e-04 | 86 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05220 | Colorectum | AD | Chronic myeloid leukemia | 31/2092 | 76/8465 | 1.41e-03 | 8.46e-03 | 5.39e-03 | 31 |
hsa052201 | Colorectum | AD | Chronic myeloid leukemia | 31/2092 | 76/8465 | 1.41e-03 | 8.46e-03 | 5.39e-03 | 31 |
hsa052204 | Colorectum | FAP | Chronic myeloid leukemia | 23/1404 | 76/8465 | 2.14e-03 | 1.05e-02 | 6.39e-03 | 23 |
hsa052205 | Colorectum | FAP | Chronic myeloid leukemia | 23/1404 | 76/8465 | 2.14e-03 | 1.05e-02 | 6.39e-03 | 23 |
hsa052206 | Colorectum | CRC | Chronic myeloid leukemia | 18/1091 | 76/8465 | 6.86e-03 | 3.37e-02 | 2.28e-02 | 18 |
hsa052207 | Colorectum | CRC | Chronic myeloid leukemia | 18/1091 | 76/8465 | 6.86e-03 | 3.37e-02 | 2.28e-02 | 18 |
hsa0522021 | Liver | HCC | Chronic myeloid leukemia | 55/4020 | 76/8465 | 8.67e-06 | 6.91e-05 | 3.84e-05 | 55 |
hsa0522031 | Liver | HCC | Chronic myeloid leukemia | 55/4020 | 76/8465 | 8.67e-06 | 6.91e-05 | 3.84e-05 | 55 |
hsa0522018 | Oral cavity | OSCC | Chronic myeloid leukemia | 56/3704 | 76/8465 | 1.04e-07 | 7.43e-07 | 3.78e-07 | 56 |
hsa0522019 | Oral cavity | OSCC | Chronic myeloid leukemia | 56/3704 | 76/8465 | 1.04e-07 | 7.43e-07 | 3.78e-07 | 56 |
hsa0522025 | Oral cavity | LP | Chronic myeloid leukemia | 37/2418 | 76/8465 | 1.53e-04 | 9.08e-04 | 5.86e-04 | 37 |
hsa0522035 | Oral cavity | LP | Chronic myeloid leukemia | 37/2418 | 76/8465 | 1.53e-04 | 9.08e-04 | 5.86e-04 | 37 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BCR | SNV | Missense_Mutation | rs372445084 | c.2561G>A | p.Arg854His | p.R854H | P11274 | protein_coding | deleterious(0) | possibly_damaging(0.786) | TCGA-HU-A4HD-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
BCR | SNV | Missense_Mutation | rs201711782 | c.2720C>T | p.Pro907Leu | p.P907L | P11274 | protein_coding | tolerated(0.28) | benign(0.279) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
BCR | SNV | Missense_Mutation | novel | c.1727G>T | p.Arg576Leu | p.R576L | P11274 | protein_coding | tolerated(0.32) | benign(0.053) | TCGA-EM-A2CN-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
613 | BCR | TUMOR SUPPRESSOR, SERINE THREONINE KINASE, TYROSINE KINASE, CLINICALLY ACTIONABLE, KINASE, ENZYME, DRUGGABLE GENOME | ponatinib | PONATINIB | ||
613 | BCR | TUMOR SUPPRESSOR, SERINE THREONINE KINASE, TYROSINE KINASE, CLINICALLY ACTIONABLE, KINASE, ENZYME, DRUGGABLE GENOME | Nilotinib | NILOTINIB | ||
613 | BCR | TUMOR SUPPRESSOR, SERINE THREONINE KINASE, TYROSINE KINASE, CLINICALLY ACTIONABLE, KINASE, ENZYME, DRUGGABLE GENOME | Ponatinib | PONATINIB | ||
613 | BCR | TUMOR SUPPRESSOR, SERINE THREONINE KINASE, TYROSINE KINASE, CLINICALLY ACTIONABLE, KINASE, ENZYME, DRUGGABLE GENOME | nilotinib | NILOTINIB | ||
613 | BCR | TUMOR SUPPRESSOR, SERINE THREONINE KINASE, TYROSINE KINASE, CLINICALLY ACTIONABLE, KINASE, ENZYME, DRUGGABLE GENOME | IMATINIB | IMATINIB | 22148584,24681986 | |
613 | BCR | TUMOR SUPPRESSOR, SERINE THREONINE KINASE, TYROSINE KINASE, CLINICALLY ACTIONABLE, KINASE, ENZYME, DRUGGABLE GENOME | Imatinib | IMATINIB | ||
613 | BCR | TUMOR SUPPRESSOR, SERINE THREONINE KINASE, TYROSINE KINASE, CLINICALLY ACTIONABLE, KINASE, ENZYME, DRUGGABLE GENOME | busulfan | BUSULFAN | ||
613 | BCR | TUMOR SUPPRESSOR, SERINE THREONINE KINASE, TYROSINE KINASE, CLINICALLY ACTIONABLE, KINASE, ENZYME, DRUGGABLE GENOME | Bosutinib | BOSUTINIB | ||
613 | BCR | TUMOR SUPPRESSOR, SERINE THREONINE KINASE, TYROSINE KINASE, CLINICALLY ACTIONABLE, KINASE, ENZYME, DRUGGABLE GENOME | GNF-2 | CHEMBL483847 | 16415863 | |
613 | BCR | TUMOR SUPPRESSOR, SERINE THREONINE KINASE, TYROSINE KINASE, CLINICALLY ACTIONABLE, KINASE, ENZYME, DRUGGABLE GENOME | vincristine | VINCRISTINE |
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