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Gene: AUTS2 |
Gene summary for AUTS2 |
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Gene information | Species | Human | Gene symbol | AUTS2 | Gene ID | 26053 |
Gene name | activator of transcription and developmental regulator AUTS2 | |
Gene Alias | FBRSL2 | |
Cytomap | 7q11.22 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q8WXX7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26053 | AUTS2 | CA_HPV_3 | Human | Cervix | CC | 2.42e-03 | 6.60e-02 | 0.0414 |
26053 | AUTS2 | CCI_2 | Human | Cervix | CC | 2.38e-05 | 8.16e-01 | 0.5249 |
26053 | AUTS2 | CCI_3 | Human | Cervix | CC | 4.81e-27 | 1.44e+00 | 0.516 |
26053 | AUTS2 | T1 | Human | Cervix | CC | 7.26e-06 | 3.69e-01 | 0.0918 |
26053 | AUTS2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.36e-06 | 5.31e-01 | -0.0811 |
26053 | AUTS2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.18e-03 | 5.24e-01 | -0.1088 |
26053 | AUTS2 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.59e-15 | 6.74e-01 | -0.1954 |
26053 | AUTS2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.59e-05 | 7.23e-01 | 0.0112 |
26053 | AUTS2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.40e-08 | 6.89e-01 | 0.0588 |
26053 | AUTS2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.45e-16 | -5.47e-01 | 0.3005 |
26053 | AUTS2 | A015-C-203 | Human | Colorectum | FAP | 4.60e-23 | -1.87e-01 | -0.1294 |
26053 | AUTS2 | A015-C-204 | Human | Colorectum | FAP | 1.14e-02 | -2.15e-01 | -0.0228 |
26053 | AUTS2 | A002-C-201 | Human | Colorectum | FAP | 1.88e-08 | -2.72e-01 | 0.0324 |
26053 | AUTS2 | A002-C-203 | Human | Colorectum | FAP | 1.63e-03 | 2.75e-01 | 0.2786 |
26053 | AUTS2 | A001-C-119 | Human | Colorectum | FAP | 2.97e-03 | -3.70e-01 | -0.1557 |
26053 | AUTS2 | A001-C-108 | Human | Colorectum | FAP | 1.15e-12 | -5.55e-02 | -0.0272 |
26053 | AUTS2 | A002-C-205 | Human | Colorectum | FAP | 1.54e-15 | -1.55e-01 | -0.1236 |
26053 | AUTS2 | A015-C-006 | Human | Colorectum | FAP | 8.08e-10 | -3.04e-01 | -0.0994 |
26053 | AUTS2 | A015-C-106 | Human | Colorectum | FAP | 2.66e-08 | 7.31e-03 | -0.0511 |
26053 | AUTS2 | A002-C-114 | Human | Colorectum | FAP | 2.23e-15 | -4.69e-01 | -0.1561 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:00072656 | Cervix | CC | Ras protein signal transduction | 79/2311 | 337/18723 | 9.49e-09 | 7.77e-07 | 79 |
GO:00975817 | Cervix | CC | lamellipodium organization | 31/2311 | 90/18723 | 4.57e-08 | 2.76e-06 | 31 |
GO:00300325 | Cervix | CC | lamellipodium assembly | 26/2311 | 72/18723 | 1.87e-07 | 8.48e-06 | 26 |
GO:00315328 | Cervix | CC | actin cytoskeleton reorganization | 31/2311 | 107/18723 | 3.34e-06 | 8.99e-05 | 31 |
GO:00313467 | Cervix | CC | positive regulation of cell projection organization | 72/2311 | 353/18723 | 1.04e-05 | 2.32e-04 | 72 |
GO:00160498 | Cervix | CC | cell growth | 92/2311 | 482/18723 | 1.16e-05 | 2.49e-04 | 92 |
GO:19027437 | Cervix | CC | regulation of lamellipodium organization | 19/2311 | 54/18723 | 1.27e-05 | 2.60e-04 | 19 |
GO:00615647 | Cervix | CC | axon development | 89/2311 | 467/18723 | 1.71e-05 | 3.27e-04 | 89 |
GO:00465785 | Cervix | CC | regulation of Ras protein signal transduction | 44/2311 | 189/18723 | 2.05e-05 | 3.73e-04 | 44 |
GO:19027457 | Cervix | CC | positive regulation of lamellipodium organization | 14/2311 | 37/18723 | 6.97e-05 | 9.81e-04 | 14 |
GO:00074097 | Cervix | CC | axonogenesis | 78/2311 | 418/18723 | 1.14e-04 | 1.43e-03 | 78 |
GO:00165705 | Cervix | CC | histone modification | 84/2311 | 463/18723 | 1.70e-04 | 2.01e-03 | 84 |
GO:00105916 | Cervix | CC | regulation of lamellipodium assembly | 14/2311 | 42/18723 | 3.32e-04 | 3.49e-03 | 14 |
GO:00105926 | Cervix | CC | positive regulation of lamellipodium assembly | 11/2311 | 29/18723 | 4.06e-04 | 4.15e-03 | 11 |
GO:00349685 | Cervix | CC | histone lysine methylation | 27/2311 | 115/18723 | 6.61e-04 | 6.09e-03 | 27 |
GO:00310565 | Cervix | CC | regulation of histone modification | 33/2311 | 152/18723 | 7.97e-04 | 7.00e-03 | 33 |
GO:00605606 | Cervix | CC | developmental growth involved in morphogenesis | 46/2311 | 234/18723 | 8.82e-04 | 7.63e-03 | 46 |
GO:01200328 | Cervix | CC | regulation of plasma membrane bounded cell projection assembly | 38/2311 | 186/18723 | 1.14e-03 | 9.35e-03 | 38 |
GO:00604917 | Cervix | CC | regulation of cell projection assembly | 38/2311 | 188/18723 | 1.40e-03 | 1.10e-02 | 38 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AUTS2 | SNV | Missense_Mutation | c.2701C>T | p.Arg901Cys | p.R901C | Q8WXX7 | protein_coding | tolerated(0.08) | possibly_damaging(0.878) | TCGA-05-4403-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AUTS2 | SNV | Missense_Mutation | rs772352925 | c.356N>T | p.Thr119Met | p.T119M | Q8WXX7 | protein_coding | deleterious(0.02) | possibly_damaging(0.502) | TCGA-05-5423-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AUTS2 | SNV | Missense_Mutation | c.1756N>T | p.Ala586Ser | p.A586S | Q8WXX7 | protein_coding | tolerated(0.21) | possibly_damaging(0.854) | TCGA-35-4122-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AUTS2 | SNV | Missense_Mutation | c.608N>T | p.Arg203Leu | p.R203L | Q8WXX7 | protein_coding | deleterious(0) | possibly_damaging(0.736) | TCGA-50-6594-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
AUTS2 | SNV | Missense_Mutation | c.3461N>A | p.Arg1154His | p.R1154H | Q8WXX7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-55-1596-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
AUTS2 | SNV | Missense_Mutation | novel | c.3560C>A | p.Pro1187Gln | p.P1187Q | Q8WXX7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-55-6979-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
AUTS2 | SNV | Missense_Mutation | c.2143N>T | p.Ala715Ser | p.A715S | Q8WXX7 | protein_coding | tolerated(0.28) | possibly_damaging(0.48) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
AUTS2 | SNV | Missense_Mutation | novel | c.2596N>G | p.Leu866Val | p.L866V | Q8WXX7 | protein_coding | tolerated(0.07) | possibly_damaging(0.64) | TCGA-69-7974-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
AUTS2 | SNV | Missense_Mutation | c.2729N>C | p.Lys910Thr | p.K910T | Q8WXX7 | protein_coding | deleterious(0.01) | probably_damaging(0.91) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |
AUTS2 | SNV | Missense_Mutation | novel | c.550N>T | p.Asp184Tyr | p.D184Y | Q8WXX7 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-75-6211-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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