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Gene: ARHGEF7 |
Gene summary for ARHGEF7 |
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Gene information | Species | Human | Gene symbol | ARHGEF7 | Gene ID | 8874 |
Gene name | Rho guanine nucleotide exchange factor 7 | |
Gene Alias | BETA-PIX | |
Cytomap | 13q34 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q14155 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8874 | ARHGEF7 | CCI_2 | Human | Cervix | CC | 1.15e-02 | 5.61e-01 | 0.5249 |
8874 | ARHGEF7 | CCI_3 | Human | Cervix | CC | 3.24e-07 | 7.19e-01 | 0.516 |
8874 | ARHGEF7 | LZE4T | Human | Esophagus | ESCC | 2.89e-08 | 2.74e-01 | 0.0811 |
8874 | ARHGEF7 | LZE7T | Human | Esophagus | ESCC | 6.10e-03 | 2.71e-01 | 0.0667 |
8874 | ARHGEF7 | LZE8T | Human | Esophagus | ESCC | 5.55e-07 | 1.96e-01 | 0.067 |
8874 | ARHGEF7 | LZE22T | Human | Esophagus | ESCC | 7.70e-03 | 2.55e-01 | 0.068 |
8874 | ARHGEF7 | LZE24T | Human | Esophagus | ESCC | 3.91e-11 | 1.79e-01 | 0.0596 |
8874 | ARHGEF7 | LZE6T | Human | Esophagus | ESCC | 3.09e-05 | 1.40e-01 | 0.0845 |
8874 | ARHGEF7 | P1T-E | Human | Esophagus | ESCC | 2.74e-04 | 2.33e-01 | 0.0875 |
8874 | ARHGEF7 | P2T-E | Human | Esophagus | ESCC | 3.83e-21 | 3.31e-01 | 0.1177 |
8874 | ARHGEF7 | P4T-E | Human | Esophagus | ESCC | 5.97e-09 | 2.66e-01 | 0.1323 |
8874 | ARHGEF7 | P5T-E | Human | Esophagus | ESCC | 2.38e-15 | 1.78e-01 | 0.1327 |
8874 | ARHGEF7 | P8T-E | Human | Esophagus | ESCC | 4.56e-21 | 3.74e-01 | 0.0889 |
8874 | ARHGEF7 | P9T-E | Human | Esophagus | ESCC | 9.06e-09 | 2.28e-01 | 0.1131 |
8874 | ARHGEF7 | P10T-E | Human | Esophagus | ESCC | 2.07e-22 | 2.99e-01 | 0.116 |
8874 | ARHGEF7 | P11T-E | Human | Esophagus | ESCC | 1.09e-10 | 4.82e-01 | 0.1426 |
8874 | ARHGEF7 | P12T-E | Human | Esophagus | ESCC | 2.52e-26 | 4.87e-01 | 0.1122 |
8874 | ARHGEF7 | P15T-E | Human | Esophagus | ESCC | 1.44e-15 | 3.06e-01 | 0.1149 |
8874 | ARHGEF7 | P16T-E | Human | Esophagus | ESCC | 3.82e-28 | 3.76e-01 | 0.1153 |
8874 | ARHGEF7 | P17T-E | Human | Esophagus | ESCC | 4.44e-08 | 2.49e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001081010 | Cervix | CC | regulation of cell-substrate adhesion | 69/2311 | 221/18723 | 8.57e-14 | 5.69e-11 | 69 |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
GO:01501159 | Cervix | CC | cell-substrate junction organization | 37/2311 | 101/18723 | 3.20e-10 | 4.46e-08 | 37 |
GO:004325410 | Cervix | CC | regulation of protein-containing complex assembly | 96/2311 | 428/18723 | 2.91e-09 | 3.05e-07 | 96 |
GO:00070448 | Cervix | CC | cell-substrate junction assembly | 34/2311 | 95/18723 | 3.35e-09 | 3.45e-07 | 34 |
GO:00071608 | Cervix | CC | cell-matrix adhesion | 60/2311 | 233/18723 | 1.58e-08 | 1.23e-06 | 60 |
GO:00430877 | Cervix | CC | regulation of GTPase activity | 79/2311 | 348/18723 | 4.21e-08 | 2.60e-06 | 79 |
GO:00975817 | Cervix | CC | lamellipodium organization | 31/2311 | 90/18723 | 4.57e-08 | 2.76e-06 | 31 |
GO:005125810 | Cervix | CC | protein polymerization | 70/2311 | 297/18723 | 5.20e-08 | 3.11e-06 | 70 |
GO:19000249 | Cervix | CC | regulation of substrate adhesion-dependent cell spreading | 23/2311 | 57/18723 | 8.94e-08 | 5.04e-06 | 23 |
GO:005109810 | Cervix | CC | regulation of binding | 80/2311 | 363/18723 | 1.32e-07 | 6.42e-06 | 80 |
GO:00300325 | Cervix | CC | lamellipodium assembly | 26/2311 | 72/18723 | 1.87e-07 | 8.48e-06 | 26 |
GO:003227110 | Cervix | CC | regulation of protein polymerization | 57/2311 | 233/18723 | 2.37e-07 | 1.03e-05 | 57 |
GO:00107699 | Cervix | CC | regulation of cell morphogenesis involved in differentiation | 31/2311 | 96/18723 | 2.43e-07 | 1.05e-05 | 31 |
GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
GO:00480417 | Cervix | CC | focal adhesion assembly | 28/2311 | 87/18723 | 9.86e-07 | 3.45e-05 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0481016 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa0513516 | Cervix | CC | Yersinia infection | 39/1267 | 137/8465 | 3.27e-05 | 2.41e-04 | 1.42e-04 | 39 |
hsa0481017 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa0513517 | Cervix | CC | Yersinia infection | 39/1267 | 137/8465 | 3.27e-05 | 2.41e-04 | 1.42e-04 | 39 |
hsa0513526 | Esophagus | ESCC | Yersinia infection | 100/4205 | 137/8465 | 1.80e-08 | 1.59e-07 | 8.12e-08 | 100 |
hsa0481028 | Esophagus | ESCC | Regulation of actin cytoskeleton | 133/4205 | 229/8465 | 5.94e-03 | 1.48e-02 | 7.56e-03 | 133 |
hsa05135111 | Esophagus | ESCC | Yersinia infection | 100/4205 | 137/8465 | 1.80e-08 | 1.59e-07 | 8.12e-08 | 100 |
hsa04810112 | Esophagus | ESCC | Regulation of actin cytoskeleton | 133/4205 | 229/8465 | 5.94e-03 | 1.48e-02 | 7.56e-03 | 133 |
hsa0481010 | Liver | NAFLD | Regulation of actin cytoskeleton | 50/1043 | 229/8465 | 3.01e-05 | 7.59e-04 | 6.11e-04 | 50 |
hsa0513512 | Liver | NAFLD | Yersinia infection | 33/1043 | 137/8465 | 9.44e-05 | 1.94e-03 | 1.56e-03 | 33 |
hsa0481011 | Liver | NAFLD | Regulation of actin cytoskeleton | 50/1043 | 229/8465 | 3.01e-05 | 7.59e-04 | 6.11e-04 | 50 |
hsa0513513 | Liver | NAFLD | Yersinia infection | 33/1043 | 137/8465 | 9.44e-05 | 1.94e-03 | 1.56e-03 | 33 |
hsa0513542 | Liver | HCC | Yersinia infection | 92/4020 | 137/8465 | 2.25e-06 | 2.19e-05 | 1.22e-05 | 92 |
hsa0481041 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0513552 | Liver | HCC | Yersinia infection | 92/4020 | 137/8465 | 2.25e-06 | 2.19e-05 | 1.22e-05 | 92 |
hsa0481051 | Liver | HCC | Regulation of actin cytoskeleton | 134/4020 | 229/8465 | 4.48e-04 | 1.94e-03 | 1.08e-03 | 134 |
hsa0513520 | Oral cavity | OSCC | Yersinia infection | 94/3704 | 137/8465 | 2.85e-09 | 3.08e-08 | 1.57e-08 | 94 |
hsa0481026 | Oral cavity | OSCC | Regulation of actin cytoskeleton | 129/3704 | 229/8465 | 7.14e-05 | 2.74e-04 | 1.40e-04 | 129 |
hsa05135110 | Oral cavity | OSCC | Yersinia infection | 94/3704 | 137/8465 | 2.85e-09 | 3.08e-08 | 1.57e-08 | 94 |
hsa04810111 | Oral cavity | OSCC | Regulation of actin cytoskeleton | 129/3704 | 229/8465 | 7.14e-05 | 2.74e-04 | 1.40e-04 | 129 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGEF7 | SNV | Missense_Mutation | c.1768C>T | p.His590Tyr | p.H590Y | Q14155 | protein_coding | tolerated(1) | benign(0.001) | TCGA-B7-5818-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ARHGEF7 | SNV | Missense_Mutation | rs750569242 | c.2276N>A | p.Arg759His | p.R759H | Q14155 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.714) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
ARHGEF7 | SNV | Missense_Mutation | rs755073581 | c.1676N>T | p.Ser559Leu | p.S559L | Q14155 | protein_coding | tolerated(0.65) | benign(0.096) | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ARHGEF7 | SNV | Missense_Mutation | c.1430N>C | p.Leu477Pro | p.L477P | Q14155 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARHGEF7 | SNV | Missense_Mutation | c.68C>A | p.Thr23Asn | p.T23N | Q14155 | protein_coding | tolerated_low_confidence(0.44) | benign(0.021) | TCGA-BR-A44U-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ARHGEF7 | SNV | Missense_Mutation | novel | c.1888N>A | p.Gly630Ser | p.G630S | Q14155 | protein_coding | tolerated(0.19) | probably_damaging(0.988) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
ARHGEF7 | SNV | Missense_Mutation | c.1862C>T | p.Pro621Leu | p.P621L | protein_coding | tolerated(0.05) | benign(0) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ARHGEF7 | SNV | Missense_Mutation | rs750993031 | c.440N>T | p.Ser147Leu | p.S147L | Q14155 | protein_coding | deleterious_low_confidence(0.02) | benign(0.407) | TCGA-HU-A4H0-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ARHGEF7 | SNV | Missense_Mutation | novel | c.2030C>A | p.Pro677His | p.P677H | Q14155 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
ARHGEF7 | insertion | Nonsense_Mutation | novel | c.997_998insAACC | p.Leu333Ter | p.L333* | Q14155 | protein_coding | TCGA-EL-A3ZP-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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