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Gene: ARHGAP29 |
Gene summary for ARHGAP29 |
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Gene information | Species | Human | Gene symbol | ARHGAP29 | Gene ID | 9411 |
Gene name | Rho GTPase activating protein 29 | |
Gene Alias | PARG1 | |
Cytomap | 1p22.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q52LW3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9411 | ARHGAP29 | GSM4909281 | Human | Breast | IDC | 1.31e-14 | -5.18e-01 | 0.21 |
9411 | ARHGAP29 | GSM4909282 | Human | Breast | IDC | 7.67e-11 | -4.71e-01 | -0.0288 |
9411 | ARHGAP29 | GSM4909285 | Human | Breast | IDC | 8.10e-31 | -6.77e-01 | 0.21 |
9411 | ARHGAP29 | GSM4909286 | Human | Breast | IDC | 3.21e-31 | -6.94e-01 | 0.1081 |
9411 | ARHGAP29 | GSM4909287 | Human | Breast | IDC | 3.82e-15 | -5.04e-01 | 0.2057 |
9411 | ARHGAP29 | GSM4909288 | Human | Breast | IDC | 1.38e-09 | -6.45e-01 | 0.0988 |
9411 | ARHGAP29 | GSM4909290 | Human | Breast | IDC | 3.30e-18 | -6.11e-01 | 0.2096 |
9411 | ARHGAP29 | GSM4909293 | Human | Breast | IDC | 2.06e-10 | -4.21e-01 | 0.1581 |
9411 | ARHGAP29 | GSM4909294 | Human | Breast | IDC | 5.95e-10 | -4.44e-01 | 0.2022 |
9411 | ARHGAP29 | GSM4909296 | Human | Breast | IDC | 2.19e-19 | -5.43e-01 | 0.1524 |
9411 | ARHGAP29 | GSM4909297 | Human | Breast | IDC | 1.73e-12 | -4.50e-01 | 0.1517 |
9411 | ARHGAP29 | GSM4909298 | Human | Breast | IDC | 8.72e-25 | -6.16e-01 | 0.1551 |
9411 | ARHGAP29 | GSM4909301 | Human | Breast | IDC | 1.27e-20 | -5.98e-01 | 0.1577 |
9411 | ARHGAP29 | GSM4909302 | Human | Breast | IDC | 1.78e-14 | -4.97e-01 | 0.1545 |
9411 | ARHGAP29 | GSM4909304 | Human | Breast | IDC | 2.08e-16 | -5.64e-01 | 0.1636 |
9411 | ARHGAP29 | GSM4909306 | Human | Breast | IDC | 3.79e-07 | -4.02e-01 | 0.1564 |
9411 | ARHGAP29 | GSM4909308 | Human | Breast | IDC | 3.08e-14 | -4.83e-01 | 0.158 |
9411 | ARHGAP29 | GSM4909309 | Human | Breast | IDC | 7.43e-10 | -4.45e-01 | 0.0483 |
9411 | ARHGAP29 | GSM4909311 | Human | Breast | IDC | 7.89e-23 | -5.23e-01 | 0.1534 |
9411 | ARHGAP29 | GSM4909312 | Human | Breast | IDC | 1.03e-03 | -2.80e-01 | 0.1552 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:000726610 | Esophagus | ESCC | Rho protein signal transduction | 81/8552 | 137/18723 | 1.03e-03 | 5.20e-03 | 81 |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:005105610 | Esophagus | ESCC | regulation of small GTPase mediated signal transduction | 157/8552 | 302/18723 | 1.55e-02 | 4.98e-02 | 157 |
GO:000726511 | Liver | Cirrhotic | Ras protein signal transduction | 119/4634 | 337/18723 | 8.16e-06 | 1.22e-04 | 119 |
GO:000726611 | Liver | Cirrhotic | Rho protein signal transduction | 53/4634 | 137/18723 | 2.05e-04 | 1.89e-03 | 53 |
GO:000726521 | Liver | HCC | Ras protein signal transduction | 187/7958 | 337/18723 | 8.89e-07 | 1.35e-05 | 187 |
GO:000726621 | Liver | HCC | Rho protein signal transduction | 76/7958 | 137/18723 | 1.46e-03 | 7.75e-03 | 76 |
GO:00510565 | Lung | IAC | regulation of small GTPase mediated signal transduction | 70/2061 | 302/18723 | 9.44e-10 | 1.87e-07 | 70 |
GO:00430876 | Lung | IAC | regulation of GTPase activity | 67/2061 | 348/18723 | 3.43e-06 | 1.44e-04 | 67 |
GO:00072655 | Lung | IAC | Ras protein signal transduction | 65/2061 | 337/18723 | 4.48e-06 | 1.81e-04 | 65 |
GO:00072665 | Lung | IAC | Rho protein signal transduction | 32/2061 | 137/18723 | 2.75e-05 | 7.26e-04 | 32 |
GO:00435475 | Lung | IAC | positive regulation of GTPase activity | 48/2061 | 255/18723 | 1.40e-04 | 2.60e-03 | 48 |
GO:00906303 | Lung | IAC | activation of GTPase activity | 22/2061 | 115/18723 | 6.80e-03 | 4.73e-02 | 22 |
GO:005105611 | Lung | AIS | regulation of small GTPase mediated signal transduction | 66/1849 | 302/18723 | 4.26e-10 | 9.53e-08 | 66 |
GO:004308711 | Lung | AIS | regulation of GTPase activity | 65/1849 | 348/18723 | 3.35e-07 | 2.83e-05 | 65 |
GO:000726512 | Lung | AIS | Ras protein signal transduction | 60/1849 | 337/18723 | 4.68e-06 | 2.31e-04 | 60 |
GO:000726612 | Lung | AIS | Rho protein signal transduction | 28/1849 | 137/18723 | 1.51e-04 | 3.22e-03 | 28 |
GO:004354711 | Lung | AIS | positive regulation of GTPase activity | 44/1849 | 255/18723 | 1.74e-04 | 3.64e-03 | 44 |
GO:009063011 | Lung | AIS | activation of GTPase activity | 21/1849 | 115/18723 | 4.07e-03 | 3.65e-02 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0452018 | Breast | Precancer | Adherens junction | 17/684 | 93/8465 | 1.11e-03 | 7.57e-03 | 5.80e-03 | 17 |
hsa0452019 | Breast | Precancer | Adherens junction | 17/684 | 93/8465 | 1.11e-03 | 7.57e-03 | 5.80e-03 | 17 |
hsa0452030 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa04520114 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa0452022 | Liver | Cirrhotic | Adherens junction | 52/2530 | 93/8465 | 1.36e-07 | 1.97e-06 | 1.21e-06 | 52 |
hsa0452032 | Liver | Cirrhotic | Adherens junction | 52/2530 | 93/8465 | 1.36e-07 | 1.97e-06 | 1.21e-06 | 52 |
hsa0452042 | Liver | HCC | Adherens junction | 68/4020 | 93/8465 | 3.99e-07 | 4.46e-06 | 2.48e-06 | 68 |
hsa0452052 | Liver | HCC | Adherens junction | 68/4020 | 93/8465 | 3.99e-07 | 4.46e-06 | 2.48e-06 | 68 |
hsa0452016 | Lung | IAC | Adherens junction | 37/1053 | 93/8465 | 1.99e-11 | 2.16e-09 | 1.43e-09 | 37 |
hsa0452017 | Lung | IAC | Adherens junction | 37/1053 | 93/8465 | 1.99e-11 | 2.16e-09 | 1.43e-09 | 37 |
hsa0452023 | Lung | AIS | Adherens junction | 34/961 | 93/8465 | 1.59e-10 | 1.29e-08 | 8.26e-09 | 34 |
hsa0452033 | Lung | AIS | Adherens junction | 34/961 | 93/8465 | 1.59e-10 | 1.29e-08 | 8.26e-09 | 34 |
hsa0452029 | Oral cavity | OSCC | Adherens junction | 62/3704 | 93/8465 | 6.34e-06 | 3.12e-05 | 1.59e-05 | 62 |
hsa04520113 | Oral cavity | OSCC | Adherens junction | 62/3704 | 93/8465 | 6.34e-06 | 3.12e-05 | 1.59e-05 | 62 |
hsa04520210 | Oral cavity | EOLP | Adherens junction | 31/1218 | 93/8465 | 2.94e-06 | 2.16e-05 | 1.28e-05 | 31 |
hsa0452037 | Oral cavity | EOLP | Adherens junction | 31/1218 | 93/8465 | 2.94e-06 | 2.16e-05 | 1.28e-05 | 31 |
hsa0452044 | Oral cavity | NEOLP | Adherens junction | 33/1112 | 93/8465 | 3.02e-08 | 5.34e-07 | 3.36e-07 | 33 |
hsa0452054 | Oral cavity | NEOLP | Adherens junction | 33/1112 | 93/8465 | 3.02e-08 | 5.34e-07 | 3.36e-07 | 33 |
hsa0452027 | Prostate | BPH | Adherens junction | 55/1718 | 93/8465 | 1.90e-16 | 4.18e-15 | 2.59e-15 | 55 |
hsa04520112 | Prostate | BPH | Adherens junction | 55/1718 | 93/8465 | 1.90e-16 | 4.18e-15 | 2.59e-15 | 55 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGAP29 | SNV | Missense_Mutation | novel | c.2277N>T | p.Leu759Phe | p.L759F | Q52LW3 | protein_coding | tolerated(0.15) | possibly_damaging(0.838) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
ARHGAP29 | SNV | Missense_Mutation | rs532106482 | c.611C>G | p.Ser204Cys | p.S204C | Q52LW3 | protein_coding | deleterious(0.02) | probably_damaging(0.94) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGAP29 | SNV | Missense_Mutation | rs771049716 | c.1672N>G | p.Ile558Val | p.I558V | Q52LW3 | protein_coding | tolerated(0.11) | benign(0) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARHGAP29 | SNV | Missense_Mutation | novel | c.664A>G | p.Ile222Val | p.I222V | Q52LW3 | protein_coding | tolerated(0.44) | benign(0.003) | TCGA-MN-A4N5-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARHGAP29 | SNV | Missense_Mutation | c.1603T>G | p.Phe535Val | p.F535V | Q52LW3 | protein_coding | tolerated(0.56) | benign(0.062) | TCGA-34-5232-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARHGAP29 | SNV | Missense_Mutation | c.912G>T | p.Arg304Ser | p.R304S | Q52LW3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-43-5668-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Other, specify in notesMAGE3-AS15-NSC-003 | clinical | PD | |
ARHGAP29 | SNV | Missense_Mutation | c.335T>C | p.Val112Ala | p.V112A | Q52LW3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-60-2719-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARHGAP29 | SNV | Missense_Mutation | c.3147N>C | p.Lys1049Asn | p.K1049N | Q52LW3 | protein_coding | deleterious(0.04) | benign(0.07) | TCGA-60-2720-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
ARHGAP29 | SNV | Missense_Mutation | c.2326G>C | p.Glu776Gln | p.E776Q | Q52LW3 | protein_coding | deleterious(0.01) | probably_damaging(0.969) | TCGA-66-2766-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ARHGAP29 | SNV | Missense_Mutation | rs780996785 | c.3630C>G | p.Asp1210Glu | p.D1210E | Q52LW3 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-92-7340-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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