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Gene: ANKRD31 |
Gene summary for ANKRD31 |
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Gene information | Species | Human | Gene symbol | ANKRD31 | Gene ID | 256006 |
Gene name | ankyrin repeat domain 31 | |
Gene Alias | ANKRD31 | |
Cytomap | 5q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8N7Z5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
256006 | ANKRD31 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.99e-03 | 1.12e-01 | -0.1464 |
256006 | ANKRD31 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.59e-04 | 1.59e-01 | -0.059 |
256006 | ANKRD31 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.39e-32 | 1.60e+00 | 0.0446 |
256006 | ANKRD31 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.20e-35 | 2.27e+00 | 0.0131 |
256006 | ANKRD31 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.11e-50 | 2.75e+00 | 0.0112 |
256006 | ANKRD31 | HTA11_11156_2000001011 | Human | Colorectum | AD | 2.94e-21 | 1.45e+00 | 0.0397 |
256006 | ANKRD31 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.13e-68 | 2.66e+00 | 0.0588 |
256006 | ANKRD31 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.13e-100 | 2.29e+00 | 0.3859 |
256006 | ANKRD31 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.30e-130 | 2.81e+00 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045787 | Colorectum | AD | positive regulation of cell cycle | 85/3918 | 313/18723 | 4.76e-03 | 3.22e-02 | 85 |
GO:00457871 | Colorectum | MSS | positive regulation of cell cycle | 80/3467 | 313/18723 | 1.15e-03 | 1.12e-02 | 80 |
GO:0090068 | Colorectum | MSS | positive regulation of cell cycle process | 60/3467 | 236/18723 | 5.01e-03 | 3.46e-02 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKRD31 | SNV | Missense_Mutation | novel | c.4655T>G | p.Phe1552Cys | p.F1552C | Q8N7Z5 | protein_coding | tolerated(0.09) | possibly_damaging(0.625) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ANKRD31 | SNV | Missense_Mutation | novel | c.4871N>T | p.Ser1624Phe | p.S1624F | Q8N7Z5 | protein_coding | deleterious(0.04) | probably_damaging(0.98) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD31 | SNV | Missense_Mutation | novel | c.3568N>G | p.Thr1190Ala | p.T1190A | Q8N7Z5 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD31 | SNV | Missense_Mutation | novel | c.1534N>T | p.Gly512Cys | p.G512C | Q8N7Z5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD31 | SNV | Missense_Mutation | novel | c.1030N>T | p.Pro344Ser | p.P344S | Q8N7Z5 | protein_coding | tolerated(0.23) | benign(0.009) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD31 | SNV | Missense_Mutation | novel | c.401N>G | p.Glu134Gly | p.E134G | Q8N7Z5 | protein_coding | tolerated(0.47) | benign(0) | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKRD31 | SNV | Missense_Mutation | c.2796G>T | p.Glu932Asp | p.E932D | Q8N7Z5 | protein_coding | tolerated(0.1) | benign(0.04) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANKRD31 | SNV | Missense_Mutation | novel | c.5311N>A | p.Leu1771Ile | p.L1771I | Q8N7Z5 | protein_coding | deleterious(0.01) | possibly_damaging(0.801) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ANKRD31 | SNV | Missense_Mutation | novel | c.3812N>T | p.Arg1271Ile | p.R1271I | Q8N7Z5 | protein_coding | deleterious(0.03) | benign(0) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ANKRD31 | SNV | Missense_Mutation | novel | c.2443N>G | p.Leu815Val | p.L815V | Q8N7Z5 | protein_coding | tolerated(0.11) | possibly_damaging(0.801) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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