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Gene: ANKFY1 |
Gene summary for ANKFY1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ANKFY1 | Gene ID | 51479 |
Gene name | ankyrin repeat and FYVE domain containing 1 | |
Gene Alias | ANKHZN | |
Cytomap | 17p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9P2R3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51479 | ANKFY1 | LZE4T | Human | Esophagus | ESCC | 8.77e-08 | 2.46e-01 | 0.0811 |
51479 | ANKFY1 | LZE8T | Human | Esophagus | ESCC | 2.22e-05 | 1.00e-01 | 0.067 |
51479 | ANKFY1 | LZE24T | Human | Esophagus | ESCC | 3.45e-11 | 2.54e-01 | 0.0596 |
51479 | ANKFY1 | LZE21T | Human | Esophagus | ESCC | 1.81e-06 | 2.56e-01 | 0.0655 |
51479 | ANKFY1 | P1T-E | Human | Esophagus | ESCC | 4.81e-06 | 3.38e-01 | 0.0875 |
51479 | ANKFY1 | P2T-E | Human | Esophagus | ESCC | 1.20e-12 | 2.41e-01 | 0.1177 |
51479 | ANKFY1 | P4T-E | Human | Esophagus | ESCC | 7.07e-13 | 2.54e-01 | 0.1323 |
51479 | ANKFY1 | P8T-E | Human | Esophagus | ESCC | 1.65e-19 | 3.00e-01 | 0.0889 |
51479 | ANKFY1 | P9T-E | Human | Esophagus | ESCC | 3.95e-13 | 2.09e-01 | 0.1131 |
51479 | ANKFY1 | P10T-E | Human | Esophagus | ESCC | 2.22e-11 | 1.91e-01 | 0.116 |
51479 | ANKFY1 | P11T-E | Human | Esophagus | ESCC | 4.38e-11 | 4.83e-01 | 0.1426 |
51479 | ANKFY1 | P12T-E | Human | Esophagus | ESCC | 1.76e-15 | 2.78e-01 | 0.1122 |
51479 | ANKFY1 | P15T-E | Human | Esophagus | ESCC | 1.63e-06 | 1.65e-01 | 0.1149 |
51479 | ANKFY1 | P16T-E | Human | Esophagus | ESCC | 2.69e-13 | 2.11e-01 | 0.1153 |
51479 | ANKFY1 | P17T-E | Human | Esophagus | ESCC | 4.43e-07 | 2.25e-01 | 0.1278 |
51479 | ANKFY1 | P20T-E | Human | Esophagus | ESCC | 4.59e-10 | 1.94e-01 | 0.1124 |
51479 | ANKFY1 | P21T-E | Human | Esophagus | ESCC | 1.27e-09 | 2.10e-01 | 0.1617 |
51479 | ANKFY1 | P22T-E | Human | Esophagus | ESCC | 1.14e-15 | 1.54e-01 | 0.1236 |
51479 | ANKFY1 | P23T-E | Human | Esophagus | ESCC | 9.99e-11 | 2.12e-01 | 0.108 |
51479 | ANKFY1 | P24T-E | Human | Esophagus | ESCC | 3.84e-12 | 2.41e-01 | 0.1287 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
GO:000703417 | Esophagus | ESCC | vacuolar transport | 119/8552 | 157/18723 | 1.16e-14 | 6.30e-13 | 119 |
GO:001648210 | Esophagus | ESCC | cytosolic transport | 124/8552 | 168/18723 | 9.69e-14 | 4.69e-12 | 124 |
GO:000689215 | Esophagus | ESCC | post-Golgi vesicle-mediated transport | 82/8552 | 104/18723 | 4.00e-12 | 1.55e-10 | 82 |
GO:00070419 | Esophagus | ESCC | lysosomal transport | 83/8552 | 114/18723 | 3.52e-09 | 7.41e-08 | 83 |
GO:003010018 | Esophagus | ESCC | regulation of endocytosis | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:00482844 | Esophagus | ESCC | organelle fusion | 94/8552 | 141/18723 | 3.72e-07 | 5.16e-06 | 94 |
GO:004580718 | Esophagus | ESCC | positive regulation of endocytosis | 69/8552 | 100/18723 | 1.97e-06 | 2.29e-05 | 69 |
GO:00421477 | Esophagus | ESCC | retrograde transport, endosome to Golgi | 63/8552 | 91/18723 | 4.58e-06 | 4.87e-05 | 63 |
GO:00901743 | Esophagus | ESCC | organelle membrane fusion | 73/8552 | 110/18723 | 9.29e-06 | 8.88e-05 | 73 |
GO:00069063 | Esophagus | ESCC | vesicle fusion | 70/8552 | 106/18723 | 1.82e-05 | 1.60e-04 | 70 |
GO:00610254 | Esophagus | ESCC | membrane fusion | 98/8552 | 163/18723 | 1.39e-04 | 9.41e-04 | 98 |
GO:00485483 | Esophagus | ESCC | regulation of pinocytosis | 11/8552 | 12/18723 | 1.26e-03 | 6.06e-03 | 11 |
GO:00068963 | Esophagus | ESCC | Golgi to vacuole transport | 16/8552 | 20/18723 | 1.85e-03 | 8.40e-03 | 16 |
GO:00069073 | Esophagus | ESCC | pinocytosis | 16/8552 | 22/18723 | 9.46e-03 | 3.28e-02 | 16 |
GO:004819315 | Oral cavity | OSCC | Golgi vesicle transport | 209/7305 | 296/18723 | 1.39e-28 | 6.30e-26 | 209 |
GO:00160508 | Oral cavity | OSCC | vesicle organization | 189/7305 | 300/18723 | 2.40e-17 | 2.14e-15 | 189 |
GO:00161979 | Oral cavity | OSCC | endosomal transport | 141/7305 | 230/18723 | 5.40e-12 | 2.06e-10 | 141 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKFY1 | SNV | Missense_Mutation | novel | c.2267N>T | p.Ala756Val | p.A756V | Q9P2R3 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ANKFY1 | SNV | Missense_Mutation | rs147745463 | c.1480N>A | p.Ala494Thr | p.A494T | Q9P2R3 | protein_coding | tolerated(0.1) | possibly_damaging(0.784) | TCGA-CV-7418-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ANKFY1 | SNV | Missense_Mutation | rs755051926 | c.1982T>C | p.Met661Thr | p.M661T | Q9P2R3 | protein_coding | tolerated(0.64) | benign(0.009) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ANKFY1 | SNV | Missense_Mutation | novel | c.857N>G | p.Gln286Arg | p.Q286R | Q9P2R3 | protein_coding | tolerated(0.14) | benign(0.389) | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ANKFY1 | SNV | Missense_Mutation | novel | c.2863N>A | p.Ala955Thr | p.A955T | Q9P2R3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-UF-A7JH-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ANKFY1 | SNV | Missense_Mutation | novel | c.2101N>A | p.Leu701Ile | p.L701I | Q9P2R3 | protein_coding | deleterious(0.01) | benign(0.043) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
ANKFY1 | SNV | Missense_Mutation | novel | c.188N>C | p.Val63Ala | p.V63A | Q9P2R3 | protein_coding | tolerated(0.05) | probably_damaging(0.972) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
ANKFY1 | SNV | Missense_Mutation | rs372638146 | c.2740C>T | p.Arg914Trp | p.R914W | Q9P2R3 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ANKFY1 | SNV | Missense_Mutation | c.3505N>T | p.Arg1169Cys | p.R1169C | Q9P2R3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
ANKFY1 | SNV | Missense_Mutation | c.2215N>A | p.Ala739Thr | p.A739T | Q9P2R3 | protein_coding | tolerated(0.1) | benign(0.009) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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