![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ADGRG6 |
Gene summary for ADGRG6 |
![]() |
Gene information | Species | Human | Gene symbol | ADGRG6 | Gene ID | 57211 |
Gene name | adhesion G protein-coupled receptor G6 | |
Gene Alias | APG1 | |
Cytomap | 6q24.2 | |
Gene Type | protein-coding | GO ID | GO:0003007 | UniProtAcc | Q86SQ4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57211 | ADGRG6 | NAFLD1 | Human | Liver | NAFLD | 9.15e-11 | 1.02e+00 | -0.04 |
57211 | ADGRG6 | S43 | Human | Liver | Cirrhotic | 4.66e-09 | -8.30e-02 | -0.0187 |
57211 | ADGRG6 | HCC1_Meng | Human | Liver | HCC | 1.02e-89 | -5.60e-02 | 0.0246 |
57211 | ADGRG6 | HCC2_Meng | Human | Liver | HCC | 3.22e-50 | 1.98e-01 | 0.0107 |
57211 | ADGRG6 | cirrhotic1 | Human | Liver | Cirrhotic | 5.43e-07 | -2.94e-01 | 0.0202 |
57211 | ADGRG6 | cirrhotic2 | Human | Liver | Cirrhotic | 2.74e-06 | -2.36e-01 | 0.0201 |
57211 | ADGRG6 | cirrhotic3 | Human | Liver | Cirrhotic | 4.38e-03 | -3.18e-01 | 0.0215 |
57211 | ADGRG6 | HCC2 | Human | Liver | HCC | 3.05e-06 | 3.26e+00 | 0.5341 |
57211 | ADGRG6 | HCC5 | Human | Liver | HCC | 5.01e-03 | 7.43e-01 | 0.4932 |
57211 | ADGRG6 | Pt13.a | Human | Liver | HCC | 6.25e-16 | -4.44e-01 | 0.021 |
57211 | ADGRG6 | Pt13.b | Human | Liver | HCC | 6.54e-08 | -4.44e-01 | 0.0251 |
57211 | ADGRG6 | Pt13.c | Human | Liver | HCC | 1.36e-04 | -4.44e-01 | 0.0076 |
57211 | ADGRG6 | Pt14.d | Human | Liver | HCC | 1.22e-16 | -4.44e-01 | 0.0143 |
57211 | ADGRG6 | S027 | Human | Liver | HCC | 2.34e-09 | 1.14e+00 | 0.2446 |
57211 | ADGRG6 | S028 | Human | Liver | HCC | 1.21e-24 | 1.21e+00 | 0.2503 |
57211 | ADGRG6 | S029 | Human | Liver | HCC | 3.07e-17 | 1.18e+00 | 0.2581 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042063 | Liver | Cirrhotic | gliogenesis | 98/4634 | 301/18723 | 1.28e-03 | 8.60e-03 | 98 |
GO:0010001 | Liver | Cirrhotic | glial cell differentiation | 75/4634 | 225/18723 | 2.24e-03 | 1.36e-02 | 75 |
GO:0042552 | Liver | Cirrhotic | myelination | 46/4634 | 134/18723 | 8.04e-03 | 3.77e-02 | 46 |
GO:0007272 | Liver | Cirrhotic | ensheathment of neurons | 46/4634 | 136/18723 | 1.08e-02 | 4.75e-02 | 46 |
GO:0008366 | Liver | Cirrhotic | axon ensheathment | 46/4634 | 136/18723 | 1.08e-02 | 4.75e-02 | 46 |
GO:00072721 | Liver | HCC | ensheathment of neurons | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00083661 | Liver | HCC | axon ensheathment | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00425521 | Liver | HCC | myelination | 71/7958 | 134/18723 | 9.08e-03 | 3.49e-02 | 71 |
GO:00420631 | Liver | HCC | gliogenesis | 148/7958 | 301/18723 | 1.10e-02 | 4.07e-02 | 148 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADGRG6 | SNV | Missense_Mutation | novel | c.3512N>T | p.Thr1171Ile | p.T1171I | Q86SQ4 | protein_coding | tolerated(0.12) | probably_damaging(0.993) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ADGRG6 | SNV | Missense_Mutation | rs373599767 | c.1003G>A | p.Asp335Asn | p.D335N | Q86SQ4 | protein_coding | tolerated(0.07) | possibly_damaging(0.638) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
ADGRG6 | insertion | Nonsense_Mutation | novel | c.2321_2322insTGGAAACATTACTATCCAGAATCATGATGAGGGCCCTTTGGAAAAGTGAGAAAAACCTGTTCTTGGGCCATC | p.Asn781_Leu782insHisAspGluGlyProLeuGluLysTerGluLysProValLeuGlyProSerGlyAsnIleThrIleGlnAsn | p.N781_L782insHDEGPLEK*EKPVLGPSGNITIQN | Q86SQ4 | protein_coding | TCGA-A5-A0R8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
ADGRG6 | insertion | Nonsense_Mutation | novel | c.2431_2432insTCTAGTATATACAT | p.Asn811IlefsTer2 | p.N811Ifs*2 | Q86SQ4 | protein_coding | TCGA-A5-A0R8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
ADGRG6 | insertion | Frame_Shift_Ins | novel | c.3155_3156insC | p.Lys1053GlnfsTer20 | p.K1053Qfs*20 | Q86SQ4 | protein_coding | TCGA-A5-A0R8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
ADGRG6 | insertion | Frame_Shift_Ins | novel | c.3157_3158insTTGTCTTAATATCT | p.Lys1053IlefsTer12 | p.K1053Ifs*12 | Q86SQ4 | protein_coding | TCGA-A5-A0R8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
ADGRG6 | insertion | In_Frame_Ins | novel | c.1021_1022insTTTTCTTTGACA | p.Trp341delinsPhePhePheAspArg | p.W341delinsFFFDR | Q86SQ4 | protein_coding | TCGA-AP-A0LP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Hormone Therapy | megace | SD | ||
ADGRG6 | insertion | Frame_Shift_Ins | novel | c.1023_1024insT | p.Asn342Ter | p.N342* | Q86SQ4 | protein_coding | TCGA-AP-A0LP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Hormone Therapy | megace | SD | ||
ADGRG6 | insertion | Frame_Shift_Ins | novel | c.3146_3147insCAAAATAATTACTACTAATATCATT | p.Arg1050LysfsTer31 | p.R1050Kfs*31 | Q86SQ4 | protein_coding | TCGA-B5-A11V-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ADGRG6 | deletion | Frame_Shift_Del | c.256_257delNN | p.Phe86Ter | p.F86* | Q86SQ4 | protein_coding | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |