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Gene: ADAMTSL1 |
Gene summary for ADAMTSL1 |
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Gene information | Species | Human | Gene symbol | ADAMTSL1 | Gene ID | 92949 |
Gene name | ADAMTS like 1 | |
Gene Alias | ADAMTSL-1 | |
Cytomap | 9p22.2-p22.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6MZQ3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92949 | ADAMTSL1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.73e-38 | -9.48e-01 | 0.0155 |
92949 | ADAMTSL1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.54e-07 | -5.04e-01 | -0.1808 |
92949 | ADAMTSL1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.41e-14 | -9.90e-01 | 0.0216 |
92949 | ADAMTSL1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.41e-03 | -5.83e-01 | -0.0811 |
92949 | ADAMTSL1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.05e-06 | -2.93e-01 | -0.1088 |
92949 | ADAMTSL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.05e-37 | 1.70e+00 | -0.1954 |
92949 | ADAMTSL1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.90e-16 | 1.70e-01 | -0.2602 |
92949 | ADAMTSL1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.07e-12 | -1.16e+00 | -0.2196 |
92949 | ADAMTSL1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.35e-06 | -6.08e-01 | -0.1207 |
92949 | ADAMTSL1 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.29e-14 | 8.46e-01 | -0.1526 |
92949 | ADAMTSL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.35e-08 | -7.90e-03 | -0.1464 |
92949 | ADAMTSL1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.45e-14 | 4.76e-01 | -0.1001 |
92949 | ADAMTSL1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.85e-17 | -7.98e-01 | -0.059 |
92949 | ADAMTSL1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.46e-07 | 1.07e-01 | -0.1706 |
92949 | ADAMTSL1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 8.82e-03 | 3.80e-01 | -0.1462 |
92949 | ADAMTSL1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.78e-03 | 2.39e-01 | -0.0842 |
92949 | ADAMTSL1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.12e-18 | 9.91e-01 | -0.0179 |
92949 | ADAMTSL1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.48e-16 | -7.55e-01 | 0.096 |
92949 | ADAMTSL1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.12e-03 | -6.72e-01 | 0.0446 |
92949 | ADAMTSL1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.45e-10 | -1.14e+00 | 0.0451 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAMTSL1 | SNV | Missense_Mutation | novel | c.5258N>A | p.Ser1753Tyr | p.S1753Y | Q8N6G6 | protein_coding | deleterious(0.02) | possibly_damaging(0.58) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
ADAMTSL1 | SNV | Missense_Mutation | rs201225408 | c.647N>A | p.Arg216His | p.R216H | Q8N6G6 | protein_coding | deleterious(0.01) | benign(0.03) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ADAMTSL1 | SNV | Missense_Mutation | novel | c.4801N>A | p.Ala1601Thr | p.A1601T | Q8N6G6 | protein_coding | tolerated(0.61) | benign(0.253) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ADAMTSL1 | SNV | Missense_Mutation | novel | c.3044N>T | p.Ala1015Val | p.A1015V | Q8N6G6 | protein_coding | tolerated(0.4) | benign(0) | TCGA-AX-A2HG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADAMTSL1 | SNV | Missense_Mutation | novel | c.860G>C | p.Ser287Thr | p.S287T | Q8N6G6 | protein_coding | deleterious(0.04) | benign(0.056) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADAMTSL1 | SNV | Missense_Mutation | c.328N>A | p.Pro110Thr | p.P110T | Q8N6G6 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
ADAMTSL1 | SNV | Missense_Mutation | rs778869300 | c.4594N>T | p.Arg1532Cys | p.R1532C | Q8N6G6 | protein_coding | deleterious(0) | possibly_damaging(0.614) | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ADAMTSL1 | SNV | Missense_Mutation | rs369442212 | c.4003N>A | p.Glu1335Lys | p.E1335K | Q8N6G6 | protein_coding | deleterious(0.02) | benign(0.094) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADAMTSL1 | SNV | Missense_Mutation | c.4273N>C | p.Val1425Leu | p.V1425L | Q8N6G6 | protein_coding | tolerated(0.37) | benign(0.001) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ADAMTSL1 | SNV | Missense_Mutation | rs749737333 | c.85N>A | p.Glu29Lys | p.E29K | Q8N6G6 | protein_coding | deleterious(0.03) | possibly_damaging(0.844) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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