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Gene: RUNX3 |
Gene summary for RUNX3 |
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Gene information | Species | Human | Gene symbol | RUNX3 | Gene ID | 864 |
Gene name | RUNX family transcription factor 3 | |
Gene Alias | AML2 | |
Cytomap | 1p36.11 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A024RAH4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
864 | RUNX3 | LZE24T | Human | Esophagus | ESCC | 4.97e-04 | 1.17e-01 | 0.0596 |
864 | RUNX3 | P2T-E | Human | Esophagus | ESCC | 1.17e-27 | 5.38e-01 | 0.1177 |
864 | RUNX3 | P5T-E | Human | Esophagus | ESCC | 6.89e-13 | 2.96e-01 | 0.1327 |
864 | RUNX3 | P8T-E | Human | Esophagus | ESCC | 4.11e-04 | 2.65e-02 | 0.0889 |
864 | RUNX3 | P10T-E | Human | Esophagus | ESCC | 8.70e-10 | 1.14e-01 | 0.116 |
864 | RUNX3 | P12T-E | Human | Esophagus | ESCC | 2.20e-07 | 7.89e-02 | 0.1122 |
864 | RUNX3 | P15T-E | Human | Esophagus | ESCC | 7.32e-06 | 1.83e-01 | 0.1149 |
864 | RUNX3 | P16T-E | Human | Esophagus | ESCC | 1.14e-12 | 2.21e-01 | 0.1153 |
864 | RUNX3 | P20T-E | Human | Esophagus | ESCC | 2.11e-04 | 3.94e-02 | 0.1124 |
864 | RUNX3 | P21T-E | Human | Esophagus | ESCC | 2.78e-09 | 1.27e-01 | 0.1617 |
864 | RUNX3 | P27T-E | Human | Esophagus | ESCC | 1.10e-08 | 1.78e-01 | 0.1055 |
864 | RUNX3 | P28T-E | Human | Esophagus | ESCC | 8.87e-17 | 3.49e-01 | 0.1149 |
864 | RUNX3 | P30T-E | Human | Esophagus | ESCC | 3.48e-02 | 1.54e-01 | 0.137 |
864 | RUNX3 | P31T-E | Human | Esophagus | ESCC | 2.33e-07 | 1.93e-01 | 0.1251 |
864 | RUNX3 | P32T-E | Human | Esophagus | ESCC | 1.78e-05 | 1.10e-01 | 0.1666 |
864 | RUNX3 | P37T-E | Human | Esophagus | ESCC | 1.96e-05 | 8.93e-02 | 0.1371 |
864 | RUNX3 | P40T-E | Human | Esophagus | ESCC | 7.38e-04 | 1.77e-01 | 0.109 |
864 | RUNX3 | P48T-E | Human | Esophagus | ESCC | 6.12e-07 | 1.06e-01 | 0.0959 |
864 | RUNX3 | P52T-E | Human | Esophagus | ESCC | 2.20e-05 | 9.49e-02 | 0.1555 |
864 | RUNX3 | P56T-E | Human | Esophagus | ESCC | 6.04e-09 | 5.96e-01 | 0.1613 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:004578527 | Esophagus | ESCC | positive regulation of cell adhesion | 255/8552 | 437/18723 | 5.07e-08 | 9.11e-07 | 255 |
GO:00715599 | Esophagus | ESCC | response to transforming growth factor beta | 157/8552 | 256/18723 | 2.95e-07 | 4.23e-06 | 157 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:005067318 | Esophagus | ESCC | epithelial cell proliferation | 238/8552 | 437/18723 | 1.19e-04 | 8.20e-04 | 238 |
GO:1903706110 | Esophagus | ESCC | regulation of hemopoiesis | 201/8552 | 367/18723 | 2.60e-04 | 1.58e-03 | 201 |
GO:19021076 | Esophagus | ESCC | positive regulation of leukocyte differentiation | 93/8552 | 157/18723 | 4.20e-04 | 2.39e-03 | 93 |
GO:19037086 | Esophagus | ESCC | positive regulation of hemopoiesis | 93/8552 | 157/18723 | 4.20e-04 | 2.39e-03 | 93 |
GO:005067817 | Esophagus | ESCC | regulation of epithelial cell proliferation | 206/8552 | 381/18723 | 5.51e-04 | 3.02e-03 | 206 |
GO:002240720 | Esophagus | ESCC | regulation of cell-cell adhesion | 239/8552 | 448/18723 | 5.88e-04 | 3.19e-03 | 239 |
GO:000268316 | Esophagus | ESCC | negative regulation of immune system process | 231/8552 | 434/18723 | 8.48e-04 | 4.36e-03 | 231 |
GO:004211018 | Esophagus | ESCC | T cell activation | 256/8552 | 487/18723 | 1.18e-03 | 5.87e-03 | 256 |
GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
GO:002240919 | Esophagus | ESCC | positive regulation of cell-cell adhesion | 155/8552 | 284/18723 | 1.50e-03 | 7.06e-03 | 155 |
GO:190210510 | Esophagus | ESCC | regulation of leukocyte differentiation | 152/8552 | 279/18723 | 1.82e-03 | 8.35e-03 | 152 |
GO:00456213 | Esophagus | ESCC | positive regulation of lymphocyte differentiation | 61/8552 | 104/18723 | 5.22e-03 | 1.97e-02 | 61 |
GO:005087015 | Esophagus | ESCC | positive regulation of T cell activation | 117/8552 | 216/18723 | 7.23e-03 | 2.62e-02 | 117 |
GO:00302176 | Esophagus | ESCC | T cell differentiation | 137/8552 | 257/18723 | 8.09e-03 | 2.87e-02 | 137 |
GO:190303916 | Esophagus | ESCC | positive regulation of leukocyte cell-cell adhesion | 128/8552 | 239/18723 | 8.40e-03 | 2.96e-02 | 128 |
GO:000715918 | Esophagus | ESCC | leukocyte cell-cell adhesion | 192/8552 | 371/18723 | 1.03e-02 | 3.51e-02 | 192 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05169210 | Esophagus | ESCC | Epstein-Barr virus infection | 151/4205 | 202/8465 | 1.55e-13 | 3.45e-12 | 1.77e-12 | 151 |
hsa046585 | Esophagus | ESCC | Th1 and Th2 cell differentiation | 58/4205 | 92/8465 | 6.49e-03 | 1.60e-02 | 8.19e-03 | 58 |
hsa0516937 | Esophagus | ESCC | Epstein-Barr virus infection | 151/4205 | 202/8465 | 1.55e-13 | 3.45e-12 | 1.77e-12 | 151 |
hsa0465812 | Esophagus | ESCC | Th1 and Th2 cell differentiation | 58/4205 | 92/8465 | 6.49e-03 | 1.60e-02 | 8.19e-03 | 58 |
hsa0516928 | Oral cavity | OSCC | Epstein-Barr virus infection | 144/3704 | 202/8465 | 1.08e-15 | 3.60e-14 | 1.83e-14 | 144 |
hsa046584 | Oral cavity | OSCC | Th1 and Th2 cell differentiation | 53/3704 | 92/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 53 |
hsa05169113 | Oral cavity | OSCC | Epstein-Barr virus infection | 144/3704 | 202/8465 | 1.08e-15 | 3.60e-14 | 1.83e-14 | 144 |
hsa0465811 | Oral cavity | OSCC | Th1 and Th2 cell differentiation | 53/3704 | 92/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 53 |
hsa0516943 | Oral cavity | EOLP | Epstein-Barr virus infection | 66/1218 | 202/8465 | 2.23e-11 | 1.20e-09 | 7.08e-10 | 66 |
hsa0465821 | Oral cavity | EOLP | Th1 and Th2 cell differentiation | 31/1218 | 92/8465 | 2.27e-06 | 1.79e-05 | 1.05e-05 | 31 |
hsa0516953 | Oral cavity | EOLP | Epstein-Barr virus infection | 66/1218 | 202/8465 | 2.23e-11 | 1.20e-09 | 7.08e-10 | 66 |
hsa0465831 | Oral cavity | EOLP | Th1 and Th2 cell differentiation | 31/1218 | 92/8465 | 2.27e-06 | 1.79e-05 | 1.05e-05 | 31 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RUNX3 | SNV | Missense_Mutation | c.968C>T | p.Pro323Leu | p.P323L | Q13761 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
RUNX3 | SNV | Missense_Mutation | novel | c.406C>T | p.Arg136Cys | p.R136C | Q13761 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RUNX3 | SNV | Missense_Mutation | rs759577669 | c.457N>T | p.Arg153Cys | p.R153C | Q13761 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-EK-A3GM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
RUNX3 | SNV | Missense_Mutation | rs764020894 | c.935N>T | p.Pro312Leu | p.P312L | Q13761 | protein_coding | deleterious(0.04) | possibly_damaging(0.46) | TCGA-FU-A3YQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RUNX3 | SNV | Missense_Mutation | rs753532923 | c.341A>G | p.Asp114Gly | p.D114G | Q13761 | protein_coding | deleterious(0) | benign(0.178) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
RUNX3 | SNV | Missense_Mutation | c.655N>T | p.Arg219Cys | p.R219C | Q13761 | protein_coding | deleterious(0) | possibly_damaging(0.649) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RUNX3 | SNV | Missense_Mutation | novel | c.697N>T | p.Leu233Phe | p.L233F | Q13761 | protein_coding | deleterious(0.02) | benign(0.084) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RUNX3 | SNV | Missense_Mutation | rs752706729 | c.1105C>T | p.Arg369Cys | p.R369C | Q13761 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
RUNX3 | SNV | Missense_Mutation | rs193187661 | c.8N>T | p.Ser3Leu | p.S3L | Q13761 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.921) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
RUNX3 | SNV | Missense_Mutation | c.655N>T | p.Arg219Cys | p.R219C | Q13761 | protein_coding | deleterious(0) | possibly_damaging(0.649) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
864 | RUNX3 | TRANSCRIPTION FACTOR | LEUCOVORIN | LEUCOVORIN | 17372756 | |
864 | RUNX3 | TRANSCRIPTION FACTOR | IRINOTECAN | IRINOTECAN | 17372756 |
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