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Gene: ZNF414 |
Gene summary for ZNF414 |
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Gene information | Species | Human | Gene symbol | ZNF414 | Gene ID | 84330 |
Gene name | zinc finger protein 414 | |
Gene Alias | ZFP414 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q96IQ9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84330 | ZNF414 | LZE20T | Human | Esophagus | ESCC | 1.26e-02 | 1.23e-01 | 0.0662 |
84330 | ZNF414 | LZE24T | Human | Esophagus | ESCC | 3.17e-06 | 1.77e-01 | 0.0596 |
84330 | ZNF414 | P1T-E | Human | Esophagus | ESCC | 1.64e-05 | 2.52e-01 | 0.0875 |
84330 | ZNF414 | P2T-E | Human | Esophagus | ESCC | 5.79e-16 | 2.96e-01 | 0.1177 |
84330 | ZNF414 | P4T-E | Human | Esophagus | ESCC | 4.13e-17 | 3.26e-01 | 0.1323 |
84330 | ZNF414 | P5T-E | Human | Esophagus | ESCC | 6.49e-58 | 1.00e+00 | 0.1327 |
84330 | ZNF414 | P8T-E | Human | Esophagus | ESCC | 2.93e-15 | 3.13e-01 | 0.0889 |
84330 | ZNF414 | P9T-E | Human | Esophagus | ESCC | 1.23e-14 | 3.25e-01 | 0.1131 |
84330 | ZNF414 | P10T-E | Human | Esophagus | ESCC | 3.87e-34 | 5.34e-01 | 0.116 |
84330 | ZNF414 | P11T-E | Human | Esophagus | ESCC | 2.46e-02 | 1.55e-01 | 0.1426 |
84330 | ZNF414 | P12T-E | Human | Esophagus | ESCC | 7.98e-13 | 2.30e-01 | 0.1122 |
84330 | ZNF414 | P15T-E | Human | Esophagus | ESCC | 8.38e-13 | 2.61e-01 | 0.1149 |
84330 | ZNF414 | P16T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.95e-01 | 0.1153 |
84330 | ZNF414 | P17T-E | Human | Esophagus | ESCC | 1.49e-02 | 1.50e-01 | 0.1278 |
84330 | ZNF414 | P19T-E | Human | Esophagus | ESCC | 5.57e-05 | 3.38e-01 | 0.1662 |
84330 | ZNF414 | P20T-E | Human | Esophagus | ESCC | 6.15e-13 | 2.66e-01 | 0.1124 |
84330 | ZNF414 | P21T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.92e-01 | 0.1617 |
84330 | ZNF414 | P22T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.66e-01 | 0.1236 |
84330 | ZNF414 | P23T-E | Human | Esophagus | ESCC | 6.47e-17 | 3.93e-01 | 0.108 |
84330 | ZNF414 | P24T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.55e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF414 | SNV | Missense_Mutation | novel | c.1139N>T | p.Ser380Leu | p.S380L | Q96IQ9 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF414 | SNV | Missense_Mutation | rs763516794 | c.437G>A | p.Arg146His | p.R146H | Q96IQ9 | protein_coding | tolerated(0.28) | probably_damaging(0.989) | TCGA-D8-A1Y3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD |
ZNF414 | SNV | Missense_Mutation | rs188164067 | c.304N>T | p.Arg102Cys | p.R102C | Q96IQ9 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF414 | SNV | Missense_Mutation | rs762887348 | c.125N>T | p.Ser42Leu | p.S42L | Q96IQ9 | protein_coding | tolerated_low_confidence(0.13) | benign(0) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF414 | SNV | Missense_Mutation | c.903N>T | p.Gln301His | p.Q301H | Q96IQ9 | protein_coding | tolerated(0.08) | probably_damaging(0.986) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF414 | SNV | Missense_Mutation | c.542G>A | p.Cys181Tyr | p.C181Y | Q96IQ9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CM-5868-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
ZNF414 | SNV | Missense_Mutation | novel | c.296C>A | p.Pro99His | p.P99H | Q96IQ9 | protein_coding | deleterious(0.05) | possibly_damaging(0.739) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF414 | SNV | Missense_Mutation | rs762887348 | c.125N>T | p.Ser42Leu | p.S42L | Q96IQ9 | protein_coding | tolerated_low_confidence(0.13) | benign(0) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF414 | SNV | Missense_Mutation | novel | c.1123N>A | p.Val375Met | p.V375M | Q96IQ9 | protein_coding | tolerated(0.17) | possibly_damaging(0.656) | TCGA-BK-A13B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ZNF414 | SNV | Missense_Mutation | novel | c.477G>A | p.Met159Ile | p.M159I | Q96IQ9 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-EY-A5W2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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