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Gene: ZFP62 |
Gene summary for ZFP62 |
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Gene information | Species | Human | Gene symbol | ZFP62 | Gene ID | 643836 |
Gene name | ZFP62 zinc finger protein | |
Gene Alias | ZET | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8NB50 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
643836 | ZFP62 | HCC1_Meng | Human | Liver | HCC | 1.12e-14 | -6.24e-03 | 0.0246 |
643836 | ZFP62 | HCC2_Meng | Human | Liver | HCC | 1.25e-08 | 7.45e-02 | 0.0107 |
643836 | ZFP62 | HCC1 | Human | Liver | HCC | 4.53e-05 | 3.20e+00 | 0.5336 |
643836 | ZFP62 | HCC2 | Human | Liver | HCC | 7.35e-03 | 2.57e+00 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFP62 | SNV | Missense_Mutation | c.1264N>A | p.Glu422Lys | p.E422K | Q8NB50 | protein_coding | tolerated(0.87) | benign(0.069) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZFP62 | SNV | Missense_Mutation | c.890N>C | p.Arg297Thr | p.R297T | Q8NB50 | protein_coding | tolerated(0.93) | possibly_damaging(0.55) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZFP62 | SNV | Missense_Mutation | c.1086G>T | p.Glu362Asp | p.E362D | Q8NB50 | protein_coding | tolerated(0.07) | probably_damaging(0.989) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZFP62 | SNV | Missense_Mutation | novel | c.183N>T | p.Met61Ile | p.M61I | Q8NB50 | protein_coding | tolerated(0.43) | benign(0.003) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ZFP62 | SNV | Missense_Mutation | novel | c.2141N>C | p.Arg714Thr | p.R714T | Q8NB50 | protein_coding | deleterious(0.04) | benign(0.155) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFP62 | SNV | Missense_Mutation | novel | c.208N>A | p.Glu70Lys | p.E70K | Q8NB50 | protein_coding | tolerated(0.36) | benign(0.14) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
ZFP62 | SNV | Missense_Mutation | c.1621N>A | p.Ala541Thr | p.A541T | Q8NB50 | protein_coding | tolerated(0.23) | benign(0.145) | TCGA-BH-A0WA-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZFP62 | SNV | Missense_Mutation | rs149065023 | c.2522N>A | p.Arg841Gln | p.R841Q | Q8NB50 | protein_coding | tolerated(0.15) | benign(0) | TCGA-GI-A2C9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | SD | |
ZFP62 | insertion | In_Frame_Ins | novel | c.183_184insCAT | p.Met61_Lys62insHis | p.M61_K62insH | Q8NB50 | protein_coding | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
ZFP62 | SNV | Missense_Mutation | c.659N>A | p.Ser220Tyr | p.S220Y | Q8NB50 | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-EK-A2PI-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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