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Gene: SCX |
Gene summary for SCX |
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Gene information | Species | Human | Gene symbol | SCX | Gene ID | 642658 |
Gene name | scleraxis bHLH transcription factor | |
Gene Alias | SCXA | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q7RTU7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
642658 | SCX | male-WTA | Human | Thyroid | PTC | 1.84e-47 | 6.68e-01 | 0.1037 |
642658 | SCX | female-WTA | Human | Thyroid | PTC | 2.41e-03 | 4.05e-01 | 0.0726 |
642658 | SCX | PTC01 | Human | Thyroid | PTC | 4.81e-09 | 4.84e-01 | 0.1899 |
642658 | SCX | PTC03 | Human | Thyroid | PTC | 1.38e-07 | 8.39e-01 | 0.1784 |
642658 | SCX | PTC04 | Human | Thyroid | PTC | 1.08e-17 | 8.71e-01 | 0.1927 |
642658 | SCX | PTC05 | Human | Thyroid | PTC | 7.86e-23 | 1.20e+00 | 0.2065 |
642658 | SCX | PTC06 | Human | Thyroid | PTC | 4.51e-63 | 2.03e+00 | 0.2057 |
642658 | SCX | PTC07 | Human | Thyroid | PTC | 1.71e-64 | 1.51e+00 | 0.2044 |
642658 | SCX | ATC13 | Human | Thyroid | ATC | 1.44e-22 | 8.69e-01 | 0.34 |
642658 | SCX | ATC5 | Human | Thyroid | ATC | 6.53e-28 | 9.02e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0071496113 | Thyroid | PTC | cellular response to external stimulus | 158/5968 | 320/18723 | 4.12e-11 | 1.47e-09 | 158 |
GO:007155919 | Thyroid | PTC | response to transforming growth factor beta | 131/5968 | 256/18723 | 9.20e-11 | 3.17e-09 | 131 |
GO:007156019 | Thyroid | PTC | cellular response to transforming growth factor beta stimulus | 126/5968 | 250/18723 | 7.34e-10 | 2.19e-08 | 126 |
GO:0071214111 | Thyroid | PTC | cellular response to abiotic stimulus | 158/5968 | 331/18723 | 9.90e-10 | 2.89e-08 | 158 |
GO:0104004111 | Thyroid | PTC | cellular response to environmental stimulus | 158/5968 | 331/18723 | 9.90e-10 | 2.89e-08 | 158 |
GO:0001503110 | Thyroid | PTC | ossification | 176/5968 | 408/18723 | 9.26e-07 | 1.40e-05 | 176 |
GO:000717819 | Thyroid | PTC | transmembrane receptor protein serine/threonine kinase signaling pathway | 156/5968 | 355/18723 | 1.02e-06 | 1.51e-05 | 156 |
GO:0009612110 | Thyroid | PTC | response to mechanical stimulus | 98/5968 | 216/18723 | 2.09e-05 | 2.09e-04 | 98 |
GO:007126016 | Thyroid | PTC | cellular response to mechanical stimulus | 44/5968 | 81/18723 | 2.34e-05 | 2.33e-04 | 44 |
GO:000736910 | Thyroid | PTC | gastrulation | 84/5968 | 185/18723 | 7.58e-05 | 6.52e-04 | 84 |
GO:0061458112 | Thyroid | PTC | reproductive system development | 173/5968 | 427/18723 | 8.70e-05 | 7.23e-04 | 173 |
GO:0048608111 | Thyroid | PTC | reproductive structure development | 170/5968 | 424/18723 | 1.86e-04 | 1.41e-03 | 170 |
GO:00603486 | Thyroid | PTC | bone development | 90/5968 | 205/18723 | 1.89e-04 | 1.42e-03 | 90 |
GO:00017046 | Thyroid | PTC | formation of primary germ layer | 57/5968 | 121/18723 | 3.23e-04 | 2.23e-03 | 57 |
GO:00301986 | Thyroid | PTC | extracellular matrix organization | 124/5968 | 301/18723 | 3.75e-04 | 2.53e-03 | 124 |
GO:00430626 | Thyroid | PTC | extracellular structure organization | 124/5968 | 302/18723 | 4.38e-04 | 2.92e-03 | 124 |
GO:00452296 | Thyroid | PTC | external encapsulating structure organization | 124/5968 | 304/18723 | 5.96e-04 | 3.79e-03 | 124 |
GO:00603244 | Thyroid | PTC | face development | 24/5968 | 44/18723 | 1.52e-03 | 8.49e-03 | 24 |
GO:00603255 | Thyroid | PTC | face morphogenesis | 17/5968 | 28/18723 | 1.55e-03 | 8.63e-03 | 17 |
GO:006053719 | Thyroid | PTC | muscle tissue development | 156/5968 | 403/18723 | 1.98e-03 | 1.06e-02 | 156 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCX | SNV | Missense_Mutation | novel | c.283N>C | p.Phe95Leu | p.F95L | Q7RTU7 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-DD-AACD-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
SCX | SNV | Missense_Mutation | novel | c.442G>A | p.Ala148Thr | p.A148T | Q7RTU7 | protein_coding | tolerated(0.37) | benign(0.006) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
SCX | SNV | Missense_Mutation | novel | c.434C>T | p.Ser145Phe | p.S145F | Q7RTU7 | protein_coding | deleterious(0.02) | benign(0.284) | TCGA-85-8071-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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