GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:00516075 | Esophagus | ESCC | defense response to virus | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:01405465 | Esophagus | ESCC | defense response to symbiont | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:003248112 | Esophagus | ESCC | positive regulation of type I interferon production | 42/8552 | 58/18723 | 3.27e-05 | 2.70e-04 | 42 |
GO:00326084 | Esophagus | ESCC | interferon-beta production | 40/8552 | 56/18723 | 8.36e-05 | 6.08e-04 | 40 |
GO:00326484 | Esophagus | ESCC | regulation of interferon-beta production | 40/8552 | 56/18723 | 8.36e-05 | 6.08e-04 | 40 |
GO:003247912 | Esophagus | ESCC | regulation of type I interferon production | 61/8552 | 95/18723 | 2.05e-04 | 1.29e-03 | 61 |
GO:003260612 | Esophagus | ESCC | type I interferon production | 61/8552 | 95/18723 | 2.05e-04 | 1.29e-03 | 61 |
GO:00327284 | Esophagus | ESCC | positive regulation of interferon-beta production | 29/8552 | 39/18723 | 2.59e-04 | 1.58e-03 | 29 |
GO:000181916 | Esophagus | ESCC | positive regulation of cytokine production | 244/8552 | 467/18723 | 2.29e-03 | 1.01e-02 | 244 |
GO:000961511 | Liver | HCC | response to virus | 210/7958 | 367/18723 | 7.32e-09 | 1.86e-07 | 210 |
GO:00516071 | Liver | HCC | defense response to virus | 151/7958 | 265/18723 | 1.27e-06 | 1.85e-05 | 151 |
GO:01405461 | Liver | HCC | defense response to symbiont | 151/7958 | 265/18723 | 1.27e-06 | 1.85e-05 | 151 |
GO:00324814 | Liver | HCC | positive regulation of type I interferon production | 41/7958 | 58/18723 | 1.29e-05 | 1.44e-04 | 41 |
GO:0032479 | Liver | HCC | regulation of type I interferon production | 60/7958 | 95/18723 | 3.84e-05 | 3.80e-04 | 60 |
GO:0032606 | Liver | HCC | type I interferon production | 60/7958 | 95/18723 | 3.84e-05 | 3.80e-04 | 60 |
GO:0032728 | Liver | HCC | positive regulation of interferon-beta production | 26/7958 | 39/18723 | 1.99e-03 | 1.01e-02 | 26 |
GO:0032608 | Liver | HCC | interferon-beta production | 34/7958 | 56/18723 | 4.54e-03 | 1.96e-02 | 34 |
GO:0032648 | Liver | HCC | regulation of interferon-beta production | 34/7958 | 56/18723 | 4.54e-03 | 1.96e-02 | 34 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
POLR3A | CD8TEFF | Lung | AAH | PLEKHG3,KIR3DL2,NCR1, etc. | 1.81e-01 | |
POLR3A | CD8TEXINT | Lung | AIS | JPT2,BCKDHB,CORO2A, etc. | 3.26e-01 | |
POLR3A | NEUT | Lung | IAC | C5orf22,SLC4A8,ZNF782, etc. | 8.91e-03 | |
POLR3A | MAIT | Lung | IAC | C5orf22,SLC4A8,ZNF782, etc. | 4.44e-16 | |
POLR3A | MDSC | Lung | IAC | C5orf22,SLC4A8,ZNF782, etc. | 0.00e+00 | |
POLR3A | CD8TEXP | Skin | ADJ | TMEM273,TSPAN14,RSPH3, etc. | 2.29e-01 | |
POLR3A | CD8TEFF | Thyroid | ADJ | EEF1G,RRN3P1,NME2, etc. | 1.02e-01 | |
POLR3A | TFH | Thyroid | ADJ | EEF1G,RRN3P1,NME2, etc. | 3.97e-02 | |
POLR3A | CD4TN | Thyroid | PTC | EEF1G,RRN3P1,NME2, etc. | 1.48e-01 | |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLR3A | SNV | Missense_Mutation | novel | c.925G>A | p.Asp309Asn | p.D309N | O14802 | protein_coding | tolerated(0.31) | benign(0.309) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
POLR3A | SNV | Missense_Mutation | | c.1522N>T | p.His508Tyr | p.H508Y | O14802 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-B6-A0WZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
POLR3A | SNV | Missense_Mutation | | c.1964T>G | p.Leu655Arg | p.L655R | O14802 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
POLR3A | SNV | Missense_Mutation | novel | c.3137N>T | p.Thr1046Ile | p.T1046I | O14802 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E2-A574-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
POLR3A | SNV | Missense_Mutation | rs768303077 | c.1277N>A | p.Thr426Lys | p.T426K | O14802 | protein_coding | tolerated(0.49) | benign(0.373) | TCGA-EW-A1P4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
POLR3A | SNV | Missense_Mutation | novel | c.1348N>A | p.Val450Ile | p.V450I | O14802 | protein_coding | tolerated(0.08) | benign(0.294) | TCGA-LD-A7W6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | letrozole | SD |
POLR3A | insertion | Frame_Shift_Ins | novel | c.1514_1515insAGTTTGTCTGTATTTTGTCATCTTTTTGGCG | p.Met505IlefsTer22 | p.M505Ifs*22 | O14802 | protein_coding | | | TCGA-A2-A04V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD |
POLR3A | insertion | Nonsense_Mutation | novel | c.2929_2930insGTACTAGCCCTTAAAACACATTCTGTCAGCTCGTTCTCTCACG | p.Ser977CysfsTer5 | p.S977Cfs*5 | O14802 | protein_coding | | | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
POLR3A | deletion | Frame_Shift_Del | | c.2015delG | p.Gly672AspfsTer39 | p.G672Dfs*39 | O14802 | protein_coding | | | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POLR3A | SNV | Missense_Mutation | | c.1495N>A | p.Asp499Asn | p.D499N | O14802 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-LP-A5U2-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |