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Gene: CD99 |
Gene summary for CD99 |
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Gene information | Species | Human | Gene symbol | CD99 | Gene ID | 4267 |
Gene name | CD99 molecule (Xg blood group) | |
Gene Alias | HBA71 | |
Cytomap | X | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | P14209 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4267 | CD99 | GSM4909281 | Human | Breast | IDC | 1.54e-23 | 5.94e-01 | 0.21 |
4267 | CD99 | GSM4909282 | Human | Breast | IDC | 1.13e-13 | 5.36e-01 | -0.0288 |
4267 | CD99 | GSM4909285 | Human | Breast | IDC | 8.77e-11 | 2.85e-01 | 0.21 |
4267 | CD99 | GSM4909286 | Human | Breast | IDC | 1.16e-19 | 2.61e-01 | 0.1081 |
4267 | CD99 | GSM4909290 | Human | Breast | IDC | 1.37e-07 | 2.72e-01 | 0.2096 |
4267 | CD99 | GSM4909291 | Human | Breast | IDC | 6.82e-08 | 4.29e-01 | 0.1753 |
4267 | CD99 | GSM4909293 | Human | Breast | IDC | 3.10e-09 | -7.79e-02 | 0.1581 |
4267 | CD99 | GSM4909297 | Human | Breast | IDC | 1.96e-04 | -2.55e-01 | 0.1517 |
4267 | CD99 | GSM4909298 | Human | Breast | IDC | 6.55e-04 | 4.68e-02 | 0.1551 |
4267 | CD99 | GSM4909301 | Human | Breast | IDC | 1.11e-06 | -3.35e-01 | 0.1577 |
4267 | CD99 | GSM4909304 | Human | Breast | IDC | 3.73e-08 | 2.48e-01 | 0.1636 |
4267 | CD99 | GSM4909308 | Human | Breast | IDC | 2.07e-04 | 8.31e-02 | 0.158 |
4267 | CD99 | GSM4909311 | Human | Breast | IDC | 6.86e-13 | -2.89e-01 | 0.1534 |
4267 | CD99 | GSM4909317 | Human | Breast | IDC | 1.16e-02 | -1.87e-01 | 0.1355 |
4267 | CD99 | GSM4909319 | Human | Breast | IDC | 6.35e-17 | -3.89e-01 | 0.1563 |
4267 | CD99 | ctrl6 | Human | Breast | Precancer | 1.65e-07 | 5.65e-01 | -0.0061 |
4267 | CD99 | brca2 | Human | Breast | Precancer | 3.20e-10 | 2.19e-01 | -0.024 |
4267 | CD99 | brca3 | Human | Breast | Precancer | 8.28e-11 | 1.97e-01 | -0.0263 |
4267 | CD99 | brca10 | Human | Breast | Precancer | 1.17e-36 | 8.64e-01 | -0.0029 |
4267 | CD99 | M1 | Human | Breast | IDC | 4.78e-08 | 1.89e-01 | 0.1577 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00975297 | Breast | Precancer | myeloid leukocyte migration | 34/1080 | 220/18723 | 1.42e-07 | 7.82e-06 | 34 |
GO:00509006 | Breast | Precancer | leukocyte migration | 47/1080 | 369/18723 | 2.82e-07 | 1.39e-05 | 47 |
GO:00341099 | Breast | Precancer | homotypic cell-cell adhesion | 18/1080 | 90/18723 | 3.15e-06 | 1.03e-04 | 18 |
GO:00975307 | Breast | Precancer | granulocyte migration | 24/1080 | 148/18723 | 4.04e-06 | 1.26e-04 | 24 |
GO:19902665 | Breast | Precancer | neutrophil migration | 20/1080 | 122/18723 | 2.13e-05 | 4.99e-04 | 20 |
GO:00026856 | Breast | Precancer | regulation of leukocyte migration | 27/1080 | 210/18723 | 7.93e-05 | 1.54e-03 | 27 |
GO:00716744 | Breast | Precancer | mononuclear cell migration | 24/1080 | 196/18723 | 4.03e-04 | 5.44e-03 | 24 |
GO:00026877 | Breast | Precancer | positive regulation of leukocyte migration | 18/1080 | 135/18723 | 7.60e-04 | 9.04e-03 | 18 |
GO:005090011 | Breast | IDC | leukocyte migration | 54/1434 | 369/18723 | 3.10e-06 | 1.15e-04 | 54 |
GO:009752911 | Breast | IDC | myeloid leukocyte migration | 37/1434 | 220/18723 | 4.65e-06 | 1.62e-04 | 37 |
GO:003410913 | Breast | IDC | homotypic cell-cell adhesion | 20/1434 | 90/18723 | 1.20e-05 | 3.17e-04 | 20 |
GO:009753011 | Breast | IDC | granulocyte migration | 27/1434 | 148/18723 | 1.98e-05 | 4.88e-04 | 27 |
GO:199026611 | Breast | IDC | neutrophil migration | 23/1434 | 122/18723 | 4.67e-05 | 1.04e-03 | 23 |
GO:000268511 | Breast | IDC | regulation of leukocyte migration | 33/1434 | 210/18723 | 6.10e-05 | 1.27e-03 | 33 |
GO:007167411 | Breast | IDC | mononuclear cell migration | 29/1434 | 196/18723 | 4.68e-04 | 6.26e-03 | 29 |
GO:000268711 | Breast | IDC | positive regulation of leukocyte migration | 21/1434 | 135/18723 | 1.42e-03 | 1.46e-02 | 21 |
GO:0072678 | Breast | IDC | T cell migration | 12/1434 | 66/18723 | 3.99e-03 | 3.23e-02 | 12 |
GO:009752921 | Breast | DCIS | myeloid leukocyte migration | 38/1390 | 220/18723 | 8.44e-07 | 3.44e-05 | 38 |
GO:005090021 | Breast | DCIS | leukocyte migration | 54/1390 | 369/18723 | 1.22e-06 | 4.78e-05 | 54 |
GO:009753021 | Breast | DCIS | granulocyte migration | 27/1390 | 148/18723 | 1.13e-05 | 2.92e-04 | 27 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0467018 | Breast | Precancer | Leukocyte transendothelial migration | 20/684 | 114/8465 | 7.26e-04 | 5.33e-03 | 4.09e-03 | 20 |
hsa0467019 | Breast | Precancer | Leukocyte transendothelial migration | 20/684 | 114/8465 | 7.26e-04 | 5.33e-03 | 4.09e-03 | 20 |
hsa0467024 | Breast | IDC | Leukocyte transendothelial migration | 21/867 | 114/8465 | 5.41e-03 | 3.13e-02 | 2.34e-02 | 21 |
hsa0467034 | Breast | IDC | Leukocyte transendothelial migration | 21/867 | 114/8465 | 5.41e-03 | 3.13e-02 | 2.34e-02 | 21 |
hsa0467044 | Breast | DCIS | Leukocyte transendothelial migration | 21/846 | 114/8465 | 4.07e-03 | 2.31e-02 | 1.70e-02 | 21 |
hsa0467054 | Breast | DCIS | Leukocyte transendothelial migration | 21/846 | 114/8465 | 4.07e-03 | 2.31e-02 | 1.70e-02 | 21 |
hsa0467020 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
hsa04670110 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
hsa0451441 | Cervix | N_HPV | Cell adhesion molecules | 18/349 | 157/8465 | 7.71e-05 | 8.06e-04 | 6.30e-04 | 18 |
hsa0467045 | Cervix | N_HPV | Leukocyte transendothelial migration | 12/349 | 114/8465 | 2.50e-03 | 1.45e-02 | 1.13e-02 | 12 |
hsa0451451 | Cervix | N_HPV | Cell adhesion molecules | 18/349 | 157/8465 | 7.71e-05 | 8.06e-04 | 6.30e-04 | 18 |
hsa0467055 | Cervix | N_HPV | Leukocyte transendothelial migration | 12/349 | 114/8465 | 2.50e-03 | 1.45e-02 | 1.13e-02 | 12 |
hsa04670 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa046701 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa046702 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
hsa046703 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
hsa046704 | Colorectum | MSS | Leukocyte transendothelial migration | 36/1875 | 114/8465 | 1.21e-02 | 4.02e-02 | 2.46e-02 | 36 |
hsa046705 | Colorectum | MSS | Leukocyte transendothelial migration | 36/1875 | 114/8465 | 1.21e-02 | 4.02e-02 | 2.46e-02 | 36 |
hsa046706 | Colorectum | FAP | Leukocyte transendothelial migration | 37/1404 | 114/8465 | 2.12e-05 | 2.53e-04 | 1.54e-04 | 37 |
hsa046707 | Colorectum | FAP | Leukocyte transendothelial migration | 37/1404 | 114/8465 | 2.12e-05 | 2.53e-04 | 1.54e-04 | 37 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
CD99 | CD99 | CD99_CD99 | CD99 | CRC | MSS |
CD99 | CD99 | CD99_CD99 | CD99 | CRC | SER |
CD99 | CD99L2 | CD99_CD99L2 | CD99 | CRC | SER |
CD99 | PILRA | CD99_PILRA | CD99 | Endometrium | ADJ |
CD99 | PILRA | CD99_PILRA | CD99 | Endometrium | AEH |
CD99 | CD99 | CD99_CD99 | CD99 | Endometrium | AEH |
CD99 | PILRA | CD99_PILRA | CD99 | Endometrium | EEC |
CD99 | CD99 | CD99_CD99 | CD99 | Endometrium | EEC |
CD99 | PILRA | CD99_PILRA | CD99 | Endometrium | Healthy |
CD99 | CD99 | CD99_CD99 | CD99 | Endometrium | Healthy |
CD99 | PILRA | CD99_PILRA | CD99 | Esophagus | ESCC |
CD99 | CD99 | CD99_CD99 | CD99 | Esophagus | ESCC |
CD99 | CD99 | CD99_CD99 | CD99 | Esophagus | Healthy |
CD99 | CD99 | CD99_CD99 | CD99 | Esophagus | Precancer |
CD99 | CD99 | CD99_CD99 | CD99 | GC | ADJ |
CD99 | CD99 | CD99_CD99 | CD99 | GC | GC |
CD99 | CD99 | CD99_CD99 | CD99 | GC | Healthy |
CD99 | CD99 | CD99_CD99 | CD99 | GC | Precancer |
CD99 | PILRA | CD99_PILRA | CD99 | HNSCC | ADJ |
CD99 | CD99 | CD99_CD99 | CD99 | HNSCC | ADJ |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD99 | SNV | Missense_Mutation | c.343N>G | p.Arg115Gly | p.R115G | P14209 | protein_coding | tolerated(0.36) | benign(0) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CD99 | SNV | Missense_Mutation | c.315N>T | p.Lys105Asn | p.K105N | P14209 | protein_coding | tolerated(0.47) | benign(0.026) | TCGA-AO-A03O-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | |
CD99 | SNV | Missense_Mutation | c.352N>A | p.Gly118Arg | p.G118R | P14209 | protein_coding | tolerated(0.09) | benign(0.397) | TCGA-D8-A1JH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | nolvadex | SD | |
CD99 | insertion | Frame_Shift_Ins | novel | c.132_133insA | p.Lys46GlufsTer7 | p.K46Efs*7 | P14209 | protein_coding | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CD99 | SNV | Missense_Mutation | rs188016181 | c.409N>A | p.Ala137Thr | p.A137T | P14209 | protein_coding | tolerated(0.73) | probably_damaging(0.994) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
CD99 | SNV | Missense_Mutation | rs770516694 | c.403G>A | p.Val135Met | p.V135M | P14209 | protein_coding | tolerated(0.06) | possibly_damaging(0.886) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CD99 | SNV | Missense_Mutation | rs768811289 | c.203G>A | p.Arg68Gln | p.R68Q | P14209 | protein_coding | tolerated(0.55) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CD99 | SNV | Missense_Mutation | novel | c.412G>A | p.Val138Met | p.V138M | P14209 | protein_coding | deleterious(0.01) | probably_damaging(0.96) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CD99 | SNV | Missense_Mutation | rs774386901 | c.196N>A | p.Asp66Asn | p.D66N | P14209 | protein_coding | tolerated(0.35) | probably_damaging(0.948) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CD99 | SNV | Missense_Mutation | rs774386901 | c.196N>A | p.Asp66Asn | p.D66N | P14209 | protein_coding | tolerated(0.35) | probably_damaging(0.948) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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